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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: MAFF

Summary for MAFF

Gene information	Gene symbol	MAFF
	Ensembl ID	ENSG00000185022
	Entrez ID	23764
	Gene name	MAF bZIP transcription factor F
	Synonyms	hMafF
	Gene type	protein_coding
	UniProtAcc	Q9ULX9

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Dataset with differentially expressed gene: MAFF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.40345	5.23e-20
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.284103	1.38e-17
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.284975	6.19e-05
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.882234	7.16e-16
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.796998	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	-0.37446	3.38e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.267964	9.04e-38
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.282112	6.41e-15
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.269995	5.28e-09
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.349417	6.65e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.348519	3.69e-43
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.697032	5.61e-45

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Expression of MAFF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAFF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAFF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAFF	hsa-miR-6764-5p	98.6086	NM_001161572
MAFF	hsa-miR-1915-3p	97.2023	NM_001161572
MAFF	hsa-miR-3163	95.8299	NM_001161572
MAFF	hsa-miR-4728-5p	93.7604	NM_001161572
MAFF	hsa-miR-6785-5p	93.7502	NM_001161572
MAFF	hsa-miR-1973	92.9328	NM_001161572
MAFF	hsa-miR-149-3p	91.6144	NM_001161572
MAFF	hsa-miR-6883-5p	91.6144	NM_001161572
MAFF	hsa-miR-7114-5p	91.2423	NM_001161572
MAFF	hsa-miR-1283	91.0415	NM_001161572
MAFF	hsa-miR-5692a	91.0115	NM_001161572
MAFF	hsa-miR-4726-3p	88.8601	NM_001161572
MAFF	hsa-miR-3148	87.3429	NM_001161572
MAFF	hsa-miR-6840-3p	87.0334	NM_001161572
MAFF	hsa-miR-95-5p	86.3975	NM_001161572
MAFF	hsa-miR-3618	86.1927	NM_001161572
MAFF	hsa-miR-6833-5p	83.2924	NM_001161572
MAFF	hsa-miR-3918	81.6856	NM_001161572
MAFF	hsa-miR-3175	81.2206	NM_001161572
MAFF	hsa-miR-577	80.8875	NM_001161572

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Motifs and transcription factors (TFs) regulating MAFF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAFF	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
MAFF	jaspar__MA0079.5	SP1 (directAnnotation).
MAFF	jaspar__MA1561.1	SOX12 (directAnnotation).
MAFF	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
MAFF	jaspar__MA1562.1	SOX14 (directAnnotation).
MAFF	metacluster_52.10	GTF3C2; ZNF436 (directAnnotation).
MAFF	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
MAFF	taipale_tf_pairs__SOX17_ACCGAACAAT_HT	SOX17 (directAnnotation).
MAFF	transfac_pro__M06322	ZNF181 (directAnnotation).
MAFF	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
MAFF	hocomoco__BPTF_HUMAN.H11MO.0.D	BPTF (directAnnotation).
MAFF	metacluster_22.37	BACH1 (directAnnotation).
MAFF	metacluster_22.34	BACH2 (directAnnotation).
MAFF	metacluster_111.5	E4F1; E4F1 (directAnnotation).
MAFF	metacluster_198.3	ZFP64 (directAnnotation).
MAFF	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
MAFF	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
MAFF	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MAFF	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MAFF	cisbp__M01725	SREBF2 (inferredBy_Orthology).
MAFF	kznf__ZNF550_Imbeault2017_OM_RCADE	ZNF550 (directAnnotation).
MAFF	metacluster_22.13	MAFK (inferredBy_Orthology).
MAFF	transfac_pro__M01861	ATF1 (directAnnotation).
MAFF	transfac_pro__M06071	ZNF814 (directAnnotation).
MAFF	metacluster_22.36	BACH2 (directAnnotation).
MAFF	transfac_pro__M06700	ZNF71 (directAnnotation).
MAFF	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
MAFF	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
MAFF	cisbp__M04023	CREB1 (directAnnotation).
MAFF	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
MAFF	transfac_pro__M05862	ZNF615 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
MAFF	metacluster_22.1	down	Malignant cells	GSE131984_JQ1Pac	NA
MAFF	metacluster_157.2	down	Mono/Macro	GSE164551	NA
MAFF	metacluster_157.2	up	NK cells	GSE169246_PacTissue	post
MAFF	metacluster_157.2	down	Mono/Macro	GSE169246_PacTissue	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."