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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: MAFB

Summary for MAFB

Gene information	Gene symbol	MAFB
	Ensembl ID	ENSG00000204103
	Entrez ID	9935
	Gene name	MAF bZIP transcription factor B
	Synonyms	KRML
	Gene type	protein_coding
	UniProtAcc	Q9Y5Q3

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Dataset with differentially expressed gene: MAFB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.929969	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.381569	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.258848	1.15e-14
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-1.05951	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.394198	3.68e-05
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.437643	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.448869	2.64e-12
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.474263	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.7974	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Mono/Macro	-0.281948	2.30e-21

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Expression of MAFB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAFB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAFB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAFB	hsa-miR-6510-5p	99.144	NM_005461
MAFB	hsa-miR-1286	99.0925	NM_005461
MAFB	hsa-miR-548ar-3p	99.0301	NM_005461
MAFB	hsa-miR-548e-3p	98.9911	NM_005461
MAFB	hsa-miR-548bc	98.4995	NM_005461
MAFB	hsa-miR-548a-3p	98.4995	NM_005461
MAFB	hsa-miR-548az-3p	98.4995	NM_005461
MAFB	hsa-miR-548f-3p	98.4995	NM_005461
MAFB	hsa-miR-6784-3p	98.3852	NM_005461
MAFB	hsa-miR-4722-5p	97.9565	NM_005461
MAFB	hsa-miR-6862-3p	97.9199	NM_005461
MAFB	hsa-miR-10527-5p	96.309	NM_005461
MAFB	hsa-miR-150-3p	92.9737	NM_005461
MAFB	hsa-miR-5579-5p	92.8877	NM_005461
MAFB	hsa-miR-188-5p	91.7206	NM_005461
MAFB	hsa-miR-4471	91.2274	NM_005461
MAFB	hsa-miR-548bb-3p	90.9779	NM_005461
MAFB	hsa-miR-548d-3p	90.9779	NM_005461
MAFB	hsa-miR-548ac	90.9779	NM_005461
MAFB	hsa-miR-548h-3p	90.9779	NM_005461
MAFB	hsa-miR-548z	90.9779	NM_005461
MAFB	hsa-miR-3121-3p	90.9172	NM_005461
MAFB	hsa-miR-548p	90.3916	NM_005461
MAFB	hsa-miR-329-5p	90.3529	NM_005461
MAFB	hsa-miR-8059	90.1634	NM_005461
MAFB	hsa-miR-556-3p	89.3911	NM_005461
MAFB	hsa-miR-891b	89.2395	NM_005461
MAFB	hsa-miR-148a-3p	88.9174	NM_005461
MAFB	hsa-miR-152-3p	88.9174	NM_005461
MAFB	hsa-miR-148b-3p	88.9174	NM_005461
MAFB	hsa-miR-5582-3p	88.5153	NM_005461
MAFB	hsa-miR-6866-3p	86.8974	NM_005461
MAFB	hsa-miR-495-5p	86.7365	NM_005461
MAFB	hsa-miR-548aw	85.9543	NM_005461
MAFB	hsa-miR-5700	85.9511	NM_005461
MAFB	hsa-miR-4742-5p	84.6355	NM_005461
MAFB	hsa-miR-6892-3p	83.9051	NM_005461
MAFB	hsa-miR-548aj-3p	83.8819	NM_005461
MAFB	hsa-miR-548x-3p	83.8819	NM_005461
MAFB	hsa-miR-4690-5p	83.2254	NM_005461
MAFB	hsa-miR-1229-3p	82.9489	NM_005461
MAFB	hsa-miR-522-3p	82.2432	NM_005461
MAFB	hsa-miR-224-3p	82.2432	NM_005461
MAFB	hsa-miR-548n	82.0434	NM_005461
MAFB	hsa-miR-12132	81.575	NM_005461
MAFB	hsa-miR-4496	81.4147	NM_005461
MAFB	hsa-miR-338-3p	80.9578	NM_005461
MAFB	hsa-miR-4303	80.6871	NM_005461
MAFB	hsa-miR-523-3p	80.304	NM_005461

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Motifs and transcription factors (TFs) regulating MAFB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAFB	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MAFB	metacluster_38.3	STAT6; STAT6 (directAnnotation). STAT6; STAT6 (inferredBy_Orthology).
MAFB	transfac_pro__M06905	ZNF585B (directAnnotation).
MAFB	transfac_pro__M06783	ZNF443 (directAnnotation).
MAFB	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYA_CAP_repr	ELK1; FOXI1 (directAnnotation).
MAFB	transfac_pro__M04706	RELA (directAnnotation).
MAFB	tfdimers__MD00381	SOX10 (directAnnotation).
MAFB	homer__TTCCKNAGAA_STAT6	STAT6 (inferredBy_Orthology).
MAFB	transfac_pro__M06577	ZNF594 (directAnnotation).
MAFB	transfac_pro__M12441	ZNF281 (inferredBy_Orthology).
MAFB	transfac_pro__M07066	STAT6 (directAnnotation).
MAFB	metacluster_65.8	ZNF343 (directAnnotation).
MAFB	metacluster_32.24	ZNF287 (directAnnotation).
MAFB	tfdimers__MD00276	IRF1; STAT6 (directAnnotation).
MAFB	jaspar__MA1509.1	IRF6 (directAnnotation).
MAFB	metacluster_9.47	PAX7 (inferredBy_Orthology).
MAFB	taipale_tf_pairs__ELK1_SPDEF_NSMGGACGGAYNTCCKSN_CAP	ELK1; SPDEF (directAnnotation).
MAFB	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
MAFB	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
MAFB	tfdimers__MD00123	E2F1; SOX17 (directAnnotation).
MAFB	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
MAFB	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
MAFB	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
MAFB	transfac_pro__M04950	EGR1 (directAnnotation).
MAFB	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
MAFB	tfdimers__MD00036	FOS; FOSB; FOSL1; FOSL2; ILF2; JUN; JUNB; JUND; NFATC2 (directAnnotation).
MAFB	hocomoco__FOXJ3_HUMAN.H11MO.1.B	FOXJ3 (directAnnotation).
MAFB	transfac_pro__M06629	ZNF578 (directAnnotation).
MAFB	taipale_tf_pairs__HOXD12_ELK3_RSCGGAAGTCGTAAAN_CAP	ELK3; HOXD12 (directAnnotation).
MAFB	metacluster_156.3	DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
MAFB	metacluster_23.5	WT1 (directAnnotation).
MAFB	metacluster_46.5	HLF; TEF (directAnnotation).
MAFB	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
MAFB	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
MAFB	taipale_tf_pairs__FOXJ2_HOXB13_TTTWATNRNMAACA_CAP_repr	FOXJ2; HOXB13 (directAnnotation).
MAFB	cisbp__M01815	CEBPE (inferredBy_Orthology).
MAFB	transfac_pro__M05759	ZNF544 (directAnnotation).
MAFB	metacluster_47.1	E4F1; SPDEF; SPDEF (directAnnotation).
MAFB	hdpi__ZNF695	ZNF695 (directAnnotation).
MAFB	kznf__ZNF442_Imbeault2017_RP_RCADE	ZNF442 (directAnnotation).
MAFB	tfdimers__MD00351	IRF8; RFX1; RFX2; RFX3; RFX4; RFX5; RFXANK; RFXAP (directAnnotation).
MAFB	tfdimers__MD00359	CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; STAT6 (directAnnotation).
MAFB	transfac_pro__M05972	ZNF701 (directAnnotation).
MAFB	metacluster_2.4	ZIM3; ZIM3; ZIM3; ZIM3 (directAnnotation).
MAFB	tfdimers__MD00060	CRX; ZNF333 (directAnnotation).
MAFB	metacluster_150.1	PAX4 (directAnnotation).
MAFB	tfdimers__MD00051	GABPA; STAT6 (directAnnotation).
MAFB	transfac_pro__M06388	ZNF677 (directAnnotation).
MAFB	tfdimers__MD00031	MYB; ZEB1 (directAnnotation).
MAFB	kznf__ZNF675_Najafabadi2015_ChIP-seq	ZNF675 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
MAFB	metacluster_157.2	down	Mono/Macro	GSE164551	NA
MAFB	metacluster_157.2	up	Mono/Macro	GSE169246_PacAteBlood	pre
MAFB	metacluster_157.2	down	Mono/Macro	GSE169246_PacBlood	post
MAFB	tfdimers__MD00476	up	Mono/Macro	GSE197268_Tisa-cel	pre
MAFB	metacluster_157.2	up	Mono/Macro	GSE207422_Sin	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."