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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: MAF

Summary for MAF

Gene information	Gene symbol	MAF
	Ensembl ID	ENSG00000178573
	Entrez ID	4094
	Gene name	MAF bZIP transcription factor
	Synonyms	c-MAF
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MAF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.494641	5.08e-18
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.318146	0.00e+00

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Expression of MAF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAF	hsa-miR-6867-5p	100	NM_001031804
MAF	hsa-miR-3148	96.4035	NM_001031804
MAF	hsa-miR-1468-3p	96.3586	NM_001031804
MAF	hsa-miR-3185	95.9362	NM_001031804
MAF	hsa-miR-545-3p	93.1628	NM_001031804
MAF	hsa-miR-4671-3p	92.2546	NM_001031804
MAF	hsa-miR-599	92.1103	NM_001031804
MAF	hsa-miR-510-5p	92.0211	NM_001031804
MAF	hsa-miR-651-3p	91.8603	NM_001031804
MAF	hsa-miR-499b-3p	91.7261	NM_001031804
MAF	hsa-miR-499a-3p	91.7261	NM_001031804
MAF	hsa-miR-10527-5p	91.5631	NM_001031804
MAF	hsa-miR-548aj-3p	91.0144	NM_001031804
MAF	hsa-miR-548x-3p	91.0144	NM_001031804
MAF	hsa-miR-454-3p	90.4453	NM_001031804
MAF	hsa-miR-548n	90.3817	NM_001031804
MAF	hsa-miR-4276	90.1967	NM_005360
MAF	hsa-miR-130b-3p	89.455	NM_001031804
MAF	hsa-miR-4516	89.1959	NM_001031804
MAF	hsa-miR-6780b-5p	88.947	NM_001031804
MAF	hsa-miR-4271	88.947	NM_001031804
MAF	hsa-miR-4725-3p	88.947	NM_001031804
MAF	hsa-miR-130a-3p	88.2521	NM_001031804
MAF	hsa-miR-301a-3p	88.2521	NM_001031804
MAF	hsa-miR-3666	88.2521	NM_001031804
MAF	hsa-miR-301b-3p	88.2521	NM_001031804
MAF	hsa-miR-4295	88.2521	NM_001031804
MAF	hsa-miR-548aq-3p	87.8258	NM_001031804
MAF	hsa-miR-548ae-3p	87.8258	NM_001031804
MAF	hsa-miR-3179	87.4158	NM_001031804
MAF	hsa-miR-7154-5p	86.9861	NM_001031804
MAF	hsa-miR-510-3p	86.9372	NM_001031804
MAF	hsa-miR-4434	86.7965	NM_001031804
MAF	hsa-miR-5703	86.7965	NM_001031804
MAF	hsa-miR-3120-3p	86.6755	NM_001031804
MAF	hsa-miR-6811-5p	86.6221	NM_001031804
MAF	hsa-miR-6511b-5p	86.6221	NM_001031804
MAF	hsa-miR-190a-3p	86.3226	NM_005360
MAF	hsa-miR-4753-3p	86.1516	NM_001031804
MAF	hsa-miR-548p	86.1203	NM_001031804
MAF	hsa-miR-12136	85.2758	NM_001031804
MAF	hsa-miR-489-3p	83.8873	NM_005360
MAF	hsa-miR-548j-3p	83.821	NM_001031804
MAF	hsa-miR-548ah-3p	83.821	NM_001031804
MAF	hsa-miR-548am-3p	83.821	NM_001031804
MAF	hsa-miR-3163	83.7096	NM_001031804
MAF	hsa-miR-4659a-3p	83.5565	NM_005360
MAF	hsa-miR-4659b-3p	83.5565	NM_005360
MAF	hsa-miR-8060	83.4692	NM_001031804
MAF	hsa-miR-548ar-3p	83.0429	NM_001031804

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Motifs and transcription factors (TFs) regulating MAF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAF	cisbp__M02645	ETS1 (directAnnotation).
MAF	cisbp__M00808	MYPOP (inferredBy_Orthology).
MAF	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
MAF	metacluster_156.4	NFIL3 (directAnnotation). NFIL3 (inferredBy_Orthology).
MAF	transfac_public__M00040	ATF2 (directAnnotation).
MAF	metacluster_70.14	POU2F3 (directAnnotation).
MAF	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MAF	transfac_pro__M04886	ETS1 (directAnnotation).
MAF	swissregulon__mm__Pbx1	PBX1 (inferredBy_Orthology).
MAF	transfac_pro__M06794	ZNF107 (directAnnotation).
MAF	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
MAF	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
MAF	metacluster_70.15	POU2F2 (directAnnotation).
MAF	transfac_pro__M06834	PEG3 (directAnnotation).
MAF	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
MAF	metacluster_70.7	POU3F3 (inferredBy_Orthology).
MAF	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MAF	taipale_tf_pairs__TFAP4_DLX3_NNCAGCTGNNNNTAATKR_HT	DLX3; TFAP4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
MAF	metacluster_157.2	down	CD4+ T cells	GSE207422_Tor	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."