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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LZIC

Summary for LZIC

Gene information	Gene symbol	LZIC
	Ensembl ID	ENSG00000162441
	Entrez ID	84328
	Gene name	leucine zipper and CTNNBIP1 domain containing
	Synonyms	MGC15436
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LZIC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.256286	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.348416	1.18e-22
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.292905	0.00e+00

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Expression of LZIC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LZIC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LZIC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LZIC	hsa-miR-3613-3p	98.9225	NM_001316973
LZIC	hsa-miR-607	95.9475	NM_001316973
LZIC	hsa-miR-4709-3p	94.5188	NM_001316975
LZIC	hsa-miR-9903	93.8623	NM_001316976
LZIC	hsa-miR-4775	93.0536	NM_001316975
LZIC	hsa-miR-522-3p	93.0204	NM_001316976
LZIC	hsa-miR-224-3p	93.0204	NM_001316976
LZIC	hsa-miR-616-5p	92.8995	NM_001316976
LZIC	hsa-miR-373-5p	92.8995	NM_001316976
LZIC	hsa-miR-371b-5p	92.8995	NM_001316976
LZIC	hsa-miR-205-3p	91.7095	NM_001316973
LZIC	hsa-miR-548x-3p	91.0014	NM_001316976
LZIC	hsa-miR-548aj-3p	91.0014	NM_001316976
LZIC	hsa-miR-3910	89.4385	NM_001316973
LZIC	hsa-miR-548c-3p	89.0259	NM_001316976
LZIC	hsa-miR-5197-3p	88.8755	NM_001316976
LZIC	hsa-miR-548ae-3p	87.728	NM_001316976
LZIC	hsa-miR-548aq-3p	87.728	NM_001316976
LZIC	hsa-miR-548j-3p	86.2358	NM_001316976
LZIC	hsa-miR-548ah-3p	86.2358	NM_001316976
LZIC	hsa-miR-548am-3p	86.2358	NM_001316976
LZIC	hsa-miR-670-3p	85.5993	NM_001316976
LZIC	hsa-miR-6873-3p	85.4885	NM_001316976
LZIC	hsa-miR-8066	83.5219	NM_001316974
LZIC	hsa-miR-3121-5p	83.2003	NM_001316975
LZIC	hsa-miR-3671	83.1764	NM_001316976
LZIC	hsa-miR-4755-3p	82.1083	NM_001316976
LZIC	hsa-miR-590-3p	81.9701	NM_001316975
LZIC	hsa-miR-20a-5p	80.7064	NM_001316976
LZIC	hsa-miR-106b-5p	80.7064	NM_001316976
LZIC	hsa-miR-4716-5p	80.5946	NM_001316976
LZIC	hsa-miR-526b-3p	80.231	NM_001316976
LZIC	hsa-miR-519d-3p	80.231	NM_001316976
LZIC	hsa-miR-17-5p	80.231	NM_001316976
LZIC	hsa-miR-93-5p	80.231	NM_001316976
LZIC	hsa-miR-106a-5p	80.231	NM_001316976
LZIC	hsa-miR-20b-5p	80.231	NM_001316976

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Motifs and transcription factors (TFs) regulating LZIC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LZIC	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
LZIC	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
LZIC	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
LZIC	transfac_pro__M04826	EP300 (directAnnotation).
LZIC	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
LZIC	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
LZIC	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
LZIC	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
LZIC	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
LZIC	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
LZIC	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
LZIC	hdpi__FLI1	FLI1 (directAnnotation).
LZIC	hdpi__ETV4	ETV4 (directAnnotation).
LZIC	jaspar__MA1708.1	ETV7 (directAnnotation).
LZIC	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
LZIC	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
LZIC	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
LZIC	hdpi__ELF2	ELF2 (directAnnotation).
LZIC	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
LZIC	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
LZIC	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."