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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LYRM7

Summary for LYRM7

Gene information	Gene symbol	LYRM7
	Ensembl ID	ENSG00000186687
	Entrez ID	90624
	Gene name	LYR motif containing 7
	Synonyms	C5orf31\|FLJ20796\|MZM1L
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LYRM7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.29826	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.32513	0.00e+00

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Expression of LYRM7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LYRM7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LYRM7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LYRM7	hsa-miR-6867-5p	99.9481	NM_181705
LYRM7	hsa-miR-4775	99.4961	NM_181705
LYRM7	hsa-miR-371b-5p	96.3792	NM_001293735
LYRM7	hsa-miR-616-5p	96.3792	NM_001293735
LYRM7	hsa-miR-373-5p	96.3792	NM_001293735
LYRM7	hsa-miR-6759-3p	93.0813	NM_181705
LYRM7	hsa-miR-548at-5p	91.4915	NM_181705
LYRM7	hsa-miR-578	91.3529	NM_181705
LYRM7	hsa-miR-643	91.3414	NM_181705
LYRM7	hsa-miR-493-5p	91.1852	NM_181705
LYRM7	hsa-miR-3121-3p	91.149	NM_181705
LYRM7	hsa-miR-6787-3p	90.72	NM_181705
LYRM7	hsa-miR-1272	90.2861	NM_181705
LYRM7	hsa-miR-504-3p	89.745	NM_181705
LYRM7	hsa-miR-548ar-3p	89.475	NM_001293735
LYRM7	hsa-miR-9983-3p	88.2612	NM_181705
LYRM7	hsa-miR-372-5p	88.1548	NM_001293735
LYRM7	hsa-miR-548f-3p	88.1527	NM_001293735
LYRM7	hsa-miR-548a-3p	88.1527	NM_001293735
LYRM7	hsa-miR-548e-3p	88.1527	NM_001293735
LYRM7	hsa-miR-548az-3p	88.1527	NM_001293735
LYRM7	hsa-miR-548bc	88.1527	NM_001293735
LYRM7	hsa-miR-3059-5p	87.4855	NM_181705
LYRM7	hsa-miR-520f-5p	87.0244	NM_181705
LYRM7	hsa-miR-3680-3p	86.7374	NM_181705
LYRM7	hsa-miR-3675-3p	86.4151	NM_181705
LYRM7	hsa-miR-30b-5p	86.3875	NM_181705
LYRM7	hsa-miR-30a-5p	86.3875	NM_181705
LYRM7	hsa-miR-30c-5p	86.3875	NM_181705
LYRM7	hsa-miR-30d-5p	86.3875	NM_181705
LYRM7	hsa-miR-30e-5p	86.3875	NM_181705
LYRM7	hsa-miR-376a-2-5p	86.2842	NM_181705
LYRM7	hsa-miR-129-5p	85.5841	NM_181705
LYRM7	hsa-miR-590-3p	85.5828	NM_181705
LYRM7	hsa-miR-8485	85.069	NM_181705
LYRM7	hsa-miR-5010-3p	84.9174	NM_181705
LYRM7	hsa-miR-12136	84.7959	NM_181705
LYRM7	hsa-miR-5582-3p	84.5432	NM_181705
LYRM7	hsa-miR-3201	83.8322	NM_181705
LYRM7	hsa-miR-4680-3p	83.6655	NM_181705
LYRM7	hsa-miR-371a-5p	83.2108	NM_001293735
LYRM7	hsa-miR-942-3p	83.1897	NM_181705
LYRM7	hsa-miR-6734-3p	83.0674	NM_181705
LYRM7	hsa-miR-4668-3p	83.0239	NM_181705
LYRM7	hsa-miR-4517	81.5918	NM_181705
LYRM7	hsa-miR-4499	80.9859	NM_181705

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Motifs and transcription factors (TFs) regulating LYRM7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LYRM7	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
LYRM7	hdpi__ETV4	ETV4 (directAnnotation).
LYRM7	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
LYRM7	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
LYRM7	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
LYRM7	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
LYRM7	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
LYRM7	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
LYRM7	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
LYRM7	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
LYRM7	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
LYRM7	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."