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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LYRM2

Summary for LYRM2

Gene information	Gene symbol	LYRM2
	Ensembl ID	ENSG00000083099
	Entrez ID	57226
	Gene name	LYR motif containing 2
	Synonyms	DJ122O8.2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LYRM2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.522718	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.255205	5.46e-38
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.251315	1.40e-45

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Expression of LYRM2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LYRM2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LYRM2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LYRM2	hsa-miR-4659b-3p	97.3407	NM_020466
LYRM2	hsa-miR-4659a-3p	97.3407	NM_020466
LYRM2	hsa-miR-1305	93.5369	NM_020466
LYRM2	hsa-miR-222-5p	91.0555	NM_020466
LYRM2	hsa-miR-193a-3p	91.0501	NM_020466
LYRM2	hsa-miR-193b-3p	91.0501	NM_020466
LYRM2	hsa-miR-1257	88.6414	NM_020466
LYRM2	hsa-miR-8056	88.5995	NM_020466
LYRM2	hsa-miR-4753-3p	88.5159	NM_020466
LYRM2	hsa-miR-500b-3p	87.7825	NM_020466
LYRM2	hsa-miR-6809-3p	86.8612	NM_020466
LYRM2	hsa-miR-544a	86.7576	NM_020466
LYRM2	hsa-miR-3935	85.0531	NM_020466
LYRM2	hsa-miR-4328	83.2369	NM_020466
LYRM2	hsa-miR-3620-3p	81.5956	NM_020466
LYRM2	hsa-miR-590-3p	80.9991	NM_020466

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Motifs and transcription factors (TFs) regulating LYRM2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LYRM2	cisbp__M00808	MYPOP (inferredBy_Orthology).
LYRM2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LYRM2	transfac_pro__M06111	ZNF254 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."