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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LYPLA1

Summary for LYPLA1

Gene information	Gene symbol	LYPLA1
	Ensembl ID	ENSG00000120992
	Entrez ID	10434
	Gene name	lysophospholipase 1
	Synonyms	APT-1\|LPL1
	Gene type	protein_coding
	UniProtAcc	O75608

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Dataset with differentially expressed gene: LYPLA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.376505	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.625852	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.5658	3.71e-02
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.280481	1.83e-11
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.286604	4.74e-14

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Expression of LYPLA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LYPLA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LYPLA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LYPLA1	hsa-miR-607	99.4571	NM_001279356
LYPLA1	hsa-miR-6871-3p	97.3392	NM_001279356
LYPLA1	hsa-miR-513c-3p	96.8357	NM_001279356
LYPLA1	hsa-miR-513a-3p	96.8357	NM_001279356
LYPLA1	hsa-miR-3924	96.5505	NM_001279359
LYPLA1	hsa-miR-3121-3p	96.5181	NM_001279359
LYPLA1	hsa-miR-205-3p	96.3781	NM_001279356
LYPLA1	hsa-miR-1468-3p	96.284	NM_001279356
LYPLA1	hsa-miR-548x-5p	96.145	NM_001279356
LYPLA1	hsa-miR-548f-5p	96.145	NM_001279356
LYPLA1	hsa-miR-548g-5p	96.145	NM_001279356
LYPLA1	hsa-miR-548aj-5p	96.145	NM_001279356
LYPLA1	hsa-miR-3606-3p	95.8366	NM_001279356
LYPLA1	hsa-miR-548aw	95.5923	NM_001279356
LYPLA1	hsa-miR-3671	95.0949	NM_001279359
LYPLA1	hsa-miR-5692a	94.2926	NM_001279356
LYPLA1	hsa-miR-4445-5p	94.1255	NM_001279356
LYPLA1	hsa-miR-29b-2-5p	93.8469	NM_001279356
LYPLA1	hsa-miR-4422	93.5834	NM_001279359
LYPLA1	hsa-miR-200a-3p	89.1379	NM_001279356
LYPLA1	hsa-miR-141-3p	89.1379	NM_001279356
LYPLA1	hsa-miR-6835-3p	88.8581	NM_001279359
LYPLA1	hsa-miR-135a-5p	88.3455	NM_001279356
LYPLA1	hsa-miR-4282	87.8549	NM_001279359
LYPLA1	hsa-miR-138-5p	87.0651	NM_001279356
LYPLA1	hsa-miR-135b-5p	86.9476	NM_001279356
LYPLA1	hsa-miR-2054	86.9065	NM_001279359
LYPLA1	hsa-miR-5590-5p	86.5168	NM_001279359
LYPLA1	hsa-miR-450b-5p	86.281	NM_001279356
LYPLA1	hsa-miR-548ah-5p	86.153	NM_001279356
LYPLA1	hsa-miR-3609	86.153	NM_001279356
LYPLA1	hsa-miR-3613-3p	85.3742	NM_001279359
LYPLA1	hsa-miR-29c-3p	85.2196	NM_001279356
LYPLA1	hsa-miR-29a-3p	85.2196	NM_001279356
LYPLA1	hsa-miR-29b-3p	85.2196	NM_001279356
LYPLA1	hsa-miR-5682	84.8347	NM_001279356
LYPLA1	hsa-miR-221-3p	84.5098	NM_001279359
LYPLA1	hsa-miR-222-3p	84.5098	NM_001279359
LYPLA1	hsa-miR-526b-5p	83.9867	NM_001279359
LYPLA1	hsa-miR-3674	83.6379	NM_001279359
LYPLA1	hsa-miR-23b-3p	83.5245	NM_001279359
LYPLA1	hsa-miR-23a-3p	83.5245	NM_001279359
LYPLA1	hsa-miR-23c	83.5245	NM_001279359
LYPLA1	hsa-miR-3150b-3p	82.6176	NM_001279359
LYPLA1	hsa-miR-4784	82.6176	NM_001279359
LYPLA1	hsa-miR-22-5p	81.959	NM_001279359

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Motifs and transcription factors (TFs) regulating LYPLA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LYPLA1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
LYPLA1	transfac_pro__M06534	ZNF563 (directAnnotation).
LYPLA1	tfdimers__MD00369	ZNF384 (directAnnotation).
LYPLA1	transfac_pro__M05481	ZNF202 (directAnnotation).
LYPLA1	transfac_pro__M05522	ZNF341 (directAnnotation).
LYPLA1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
LYPLA1	transfac_pro__M05298	OVOL3 (directAnnotation).
LYPLA1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
LYPLA1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
LYPLA1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
LYPLA1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
LYPLA1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
LYPLA1	transfac_pro__M04950	EGR1 (directAnnotation).
LYPLA1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
LYPLA1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
LYPLA1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
LYPLA1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LYPLA1	transfac_pro__M00652	NRF1 (directAnnotation).
LYPLA1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
LYPLA1	transfac_pro__M04866	HDAC2 (directAnnotation).
LYPLA1	jaspar__MA1122.1	TFDP1 (directAnnotation).
LYPLA1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
LYPLA1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
LYPLA1	hdpi__TP73	TP73 (directAnnotation).
LYPLA1	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
LYPLA1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
LYPLA1	transfac_pro__M06173	ZNF85 (directAnnotation).
LYPLA1	hdpi__ELF2	ELF2 (directAnnotation).
LYPLA1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
LYPLA1	transfac_pro__M01298	MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."