Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LUZP1

Summary for LUZP1

Gene information	Gene symbol	LUZP1
	Ensembl ID	ENSG00000169641
	Entrez ID	7798
	Gene name	leucine zipper protein 1
	Synonyms	LUZP
	Gene type	protein_coding
	UniProtAcc	Q86V48

Top

Dataset with differentially expressed gene: LUZP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.718946	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.428897	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.46594	6.85e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.255269	1.21e-21
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.717022	0.00e+00

Top

Expression of LUZP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to LUZP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating LUZP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LUZP1	hsa-miR-195-5p	98.8517	NM_001142546
LUZP1	hsa-miR-16-5p	98.8517	NM_001142546
LUZP1	hsa-miR-15b-5p	98.6556	NM_001142546
LUZP1	hsa-miR-15a-5p	98.6556	NM_001142546
LUZP1	hsa-miR-6838-5p	98.4906	NM_001142546
LUZP1	hsa-miR-424-5p	98.3935	NM_001142546
LUZP1	hsa-miR-497-5p	98.3935	NM_001142546
LUZP1	hsa-miR-3190-5p	97.039	NM_001142546
LUZP1	hsa-miR-4689	96.9679	NM_001142546
LUZP1	hsa-miR-4784	96.3415	NM_001142546
LUZP1	hsa-miR-3150b-3p	96.3415	NM_001142546
LUZP1	hsa-miR-6512-3p	95.56	NM_001142546
LUZP1	hsa-miR-6720-5p	95.56	NM_001142546
LUZP1	hsa-miR-6858-5p	95.5086	NM_001142546
LUZP1	hsa-miR-3194-5p	95.0533	NM_001142546
LUZP1	hsa-miR-4660	94.7277	NM_001142546
LUZP1	hsa-miR-4776-3p	94.1995	NM_001142546
LUZP1	hsa-miR-4303	93.8417	NM_001142546
LUZP1	hsa-miR-665	91.4901	NM_001142546
LUZP1	hsa-miR-4795-5p	91.4424	NM_001142546
LUZP1	hsa-miR-6792-3p	91.4056	NM_001142546
LUZP1	hsa-miR-642a-5p	90.7911	NM_001142546
LUZP1	hsa-miR-5088-3p	90.7021	NM_001142546
LUZP1	hsa-miR-4721	90.2821	NM_001142546
LUZP1	hsa-miR-3934-3p	90.2673	NM_001142546
LUZP1	hsa-miR-4691-5p	90.0023	NM_001142546
LUZP1	hsa-miR-7703	89.7288	NM_001142546
LUZP1	hsa-miR-3619-5p	89.5806	NM_001142546
LUZP1	hsa-miR-214-3p	89.1091	NM_001142546
LUZP1	hsa-miR-6513-5p	89.0809	NM_001142546
LUZP1	hsa-miR-6729-3p	89.0785	NM_001142546
LUZP1	hsa-miR-4474-5p	88.6547	NM_001142546
LUZP1	hsa-miR-646	88.5731	NM_001142546
LUZP1	hsa-miR-6165	88.4834	NM_001142546
LUZP1	hsa-miR-3922-3p	88.2551	NM_001142546
LUZP1	hsa-miR-3188	87.9647	NM_001142546
LUZP1	hsa-miR-4711-5p	87.6257	NM_001142546
LUZP1	hsa-miR-3176	87.2292	NM_001142546
LUZP1	hsa-miR-3919	86.7158	NM_001142546
LUZP1	hsa-miR-4768-3p	86.1169	NM_001142546
LUZP1	hsa-miR-3613-3p	86.0086	NM_001142546
LUZP1	hsa-miR-190a-3p	85.9387	NM_001142546
LUZP1	hsa-miR-4436b-3p	84.9532	NM_001142546
LUZP1	hsa-miR-761	84.7806	NM_001142546
LUZP1	hsa-miR-4747-5p	84.7057	NM_001142546
LUZP1	hsa-miR-5196-5p	84.7057	NM_001142546
LUZP1	hsa-miR-6739-5p	84.0074	NM_001142546
LUZP1	hsa-miR-3616-3p	83.6666	NM_001142546
LUZP1	hsa-miR-5197-5p	83.6535	NM_001142546
LUZP1	hsa-miR-4649-3p	83.2317	NM_001142546

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating LUZP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LUZP1	metacluster_7.13	ZFX (directAnnotation).
LUZP1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
LUZP1	transfac_pro__M05479	ZNF580 (directAnnotation).
LUZP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LUZP1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
LUZP1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LUZP1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
LUZP1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
LUZP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LUZP1	jaspar__MA0079.5	SP1 (directAnnotation).
LUZP1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
LUZP1	transfac_pro__M01299	MECP2 (directAnnotation).
LUZP1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
LUZP1	metacluster_52.11	ZNF184 (directAnnotation).
LUZP1	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
LUZP1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
LUZP1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
LUZP1	transfac_pro__M01783	SP2 (directAnnotation).
LUZP1	cisbp__M00341	PAX6 (directAnnotation).
LUZP1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LUZP1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
LUZP1	transfac_pro__M01253	CNOT3 (directAnnotation).
LUZP1	cisbp__M00968	MTF2 (directAnnotation).
LUZP1	transfac_pro__M04817	ZBTB33 (directAnnotation).
LUZP1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
LUZP1	transfac_pro__M02089	E2F3 (directAnnotation).
LUZP1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
LUZP1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
LUZP1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
LUZP1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
LUZP1	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
LUZP1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
LUZP1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
LUZP1	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
LUZP1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
LUZP1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
LUZP1	jaspar__MA1957.1	ELK1 (directAnnotation).
LUZP1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."