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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LURAP1L

Summary for LURAP1L

Gene information	Gene symbol	LURAP1L
	Ensembl ID	ENSG00000153714
	Entrez ID	286343
	Gene name	leucine rich adaptor protein 1 like
	Synonyms	bA3L8.2\|C9orf150\|FLJ38505\|LRAP35b\|MGC46502
	Gene type	protein_coding
	UniProtAcc	Q8IV03

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Dataset with differentially expressed gene: LURAP1L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.259751	5.31e-19
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.371948	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.370358	4.06e-26

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Expression of LURAP1L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LURAP1L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LURAP1L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LURAP1L	hsa-miR-16-5p	97.4932	NM_203403
LURAP1L	hsa-miR-15b-5p	97.4932	NM_203403
LURAP1L	hsa-miR-195-5p	97.4932	NM_203403
LURAP1L	hsa-miR-15a-5p	97.4932	NM_203403
LURAP1L	hsa-miR-497-5p	96.7375	NM_203403
LURAP1L	hsa-miR-424-5p	96.7375	NM_203403
LURAP1L	hsa-miR-6838-5p	96.7375	NM_203403
LURAP1L	hsa-miR-5692a	94.9634	NM_203403
LURAP1L	hsa-miR-194-5p	94.5946	NM_203403
LURAP1L	hsa-miR-2054	94.1105	NM_203403
LURAP1L	hsa-miR-5701	93.9857	NM_203403
LURAP1L	hsa-miR-2467-3p	93.7692	NM_203403
LURAP1L	hsa-miR-30c-2-3p	93.053	NM_203403
LURAP1L	hsa-miR-30c-1-3p	93.053	NM_203403
LURAP1L	hsa-miR-6788-5p	93.053	NM_203403
LURAP1L	hsa-miR-137-3p	92.1751	NM_203403
LURAP1L	hsa-miR-6792-5p	90.6004	NM_203403
LURAP1L	hsa-miR-216a-5p	90.4062	NM_203403
LURAP1L	hsa-miR-10524-5p	87.9697	NM_203403
LURAP1L	hsa-miR-3919	87.6085	NM_203403
LURAP1L	hsa-miR-499b-5p	86.6971	NM_203403
LURAP1L	hsa-miR-1245b-3p	86.5108	NM_203403
LURAP1L	hsa-miR-503-5p	86.2944	NM_203403
LURAP1L	hsa-miR-4732-3p	85.9259	NM_203403
LURAP1L	hsa-miR-29b-2-5p	85.6623	NM_203403
LURAP1L	hsa-miR-601	85.5737	NM_203403
LURAP1L	hsa-miR-887-5p	85.1009	NM_203403
LURAP1L	hsa-miR-6878-5p	84.8808	NM_203403
LURAP1L	hsa-miR-758-5p	84.5907	NM_203403
LURAP1L	hsa-miR-361-5p	83.6945	NM_203403
LURAP1L	hsa-miR-103a-2-5p	83.3303	NM_203403
LURAP1L	hsa-miR-103a-1-5p	83.3303	NM_203403
LURAP1L	hsa-miR-4266	82.1453	NM_203403
LURAP1L	hsa-miR-4782-3p	81.562	NM_203403
LURAP1L	hsa-miR-219a-5p	81.562	NM_203403
LURAP1L	hsa-miR-6766-3p	81.562	NM_203403
LURAP1L	hsa-miR-3154	81.1786	NM_203403
LURAP1L	hsa-miR-6882-5p	81.0109	NM_203403
LURAP1L	hsa-miR-3143	80.5568	NM_203403

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Motifs and transcription factors (TFs) regulating LURAP1L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LURAP1L	metacluster_52.11	ZNF184 (directAnnotation).
LURAP1L	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."