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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LUC7L3

Summary for LUC7L3

Gene information	Gene symbol	LUC7L3
	Ensembl ID	ENSG00000108848
	Entrez ID	51747
	Gene name	LUC7 like 3 pre-mRNA splicing factor
	Synonyms	CRA\|CREAP-1\|CROP\|FLJ11063\|hLuc7A\|LUC7A\|OA48-18
	Gene type	protein_coding
	UniProtAcc	O95232

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Dataset with differentially expressed gene: LUC7L3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.53982	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.466683	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.335718	1.58e-16
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-0.25465	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.3171	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.390891	2.41e-41
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.330526	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.272103	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.683738	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.26377	3.21e-11
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.508427	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.326161	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.20327	2.17e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.254299	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.261857	3.68e-10
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.26803	2.15e-17
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.37283	0.00e+00
GSE152469	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	NA	Malignant cells	-0.309233	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.337817	0.00e+00

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Expression of LUC7L3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LUC7L3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LUC7L3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LUC7L3	hsa-miR-12136	98.1004	NM_006107
LUC7L3	hsa-miR-3133	97.38	NM_016424
LUC7L3	hsa-miR-10397-5p	97.0335	NM_016424
LUC7L3	hsa-miR-605-5p	96.7822	NM_016424
LUC7L3	hsa-miR-520g-3p	96.5039	NM_016424
LUC7L3	hsa-miR-520h	96.5039	NM_016424
LUC7L3	hsa-miR-194-5p	95.7643	NM_016424
LUC7L3	hsa-miR-1264	94.6255	NM_006107
LUC7L3	hsa-miR-2110	93.8596	NM_016424
LUC7L3	hsa-miR-362-5p	93.4499	NM_016424
LUC7L3	hsa-miR-500b-5p	93.4499	NM_016424
LUC7L3	hsa-miR-4801	93.338	NM_016424
LUC7L3	hsa-miR-450a-2-3p	93.268	NM_016424
LUC7L3	hsa-miR-4700-3p	93.0602	NM_006107
LUC7L3	hsa-miR-4731-3p	91.6972	NM_016424
LUC7L3	hsa-miR-5693	91.529	NM_006107
LUC7L3	hsa-miR-6837-3p	90.2733	NM_006107
LUC7L3	hsa-miR-9986	90.1128	NM_016424
LUC7L3	hsa-miR-1294	90.1128	NM_016424
LUC7L3	hsa-miR-3973	89.8268	NM_016424
LUC7L3	hsa-miR-5003-3p	89.2365	NM_006107
LUC7L3	hsa-miR-630	89.0425	NM_016424
LUC7L3	hsa-miR-3132	88.399	NM_016424
LUC7L3	hsa-miR-370-5p	87.5737	NM_006107
LUC7L3	hsa-miR-186-5p	87.392	NM_016424
LUC7L3	hsa-miR-12124	86.882	NM_016424
LUC7L3	hsa-miR-8084	86.1849	NM_016424
LUC7L3	hsa-miR-4708-3p	86.0562	NM_016424
LUC7L3	hsa-miR-4422	85.8715	NM_016424
LUC7L3	hsa-miR-8065	84.6537	NM_016424
LUC7L3	hsa-miR-2278	84.2258	NM_006107
LUC7L3	hsa-miR-550a-5p	83.3445	NM_016424
LUC7L3	hsa-miR-550a-3-5p	83.3445	NM_016424
LUC7L3	hsa-miR-1271-3p	83.3445	NM_016424
LUC7L3	hsa-miR-1179	82.7659	NM_016424
LUC7L3	hsa-miR-302a-5p	82.7066	NM_016424
LUC7L3	hsa-miR-4637	82.6618	NM_006107
LUC7L3	hsa-miR-299-3p	82.1033	NM_016424
LUC7L3	hsa-miR-5582-3p	81.9939	NM_006107
LUC7L3	hsa-miR-4756-3p	81.7786	NM_006107
LUC7L3	hsa-miR-3119	80.712	NM_016424
LUC7L3	hsa-miR-33a-5p	80.0493	NM_016424
LUC7L3	hsa-miR-33b-5p	80.0493	NM_016424

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Motifs and transcription factors (TFs) regulating LUC7L3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LUC7L3	metacluster_7.13	ZFX (directAnnotation).
LUC7L3	metacluster_151.2	ZNF23 (directAnnotation).
LUC7L3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LUC7L3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
LUC7L3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LUC7L3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
LUC7L3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LUC7L3	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
LUC7L3	jaspar__MA0079.5	SP1 (directAnnotation).
LUC7L3	tfdimers__MD00151	CHURC1 (directAnnotation).
LUC7L3	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
LUC7L3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
LUC7L3	transfac_pro__M02090	E2F4 (directAnnotation).
LUC7L3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
LUC7L3	cisbp__M07938	E2F1 (directAnnotation).
LUC7L3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
LUC7L3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
LUC7L3	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
LUC7L3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
LUC7L3	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
LUC7L3	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
LUC7L3	transfac_pro__M04866	HDAC2 (directAnnotation).
LUC7L3	jaspar__MA1122.1	TFDP1 (directAnnotation).
LUC7L3	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
LUC7L3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
LUC7L3	taipale_tf_pairs__HOXB13_TBX3_NNNRTAAATCACACNN_CAP_repr	HOXB13; TBX3 (directAnnotation).
LUC7L3	transfac_pro__M05574	ZFP92 (directAnnotation).
LUC7L3	taipale_tf_pairs__ETV5_FOXO1_RNCGGATGTTKWN_CAP	ETV5; FOXO1 (directAnnotation).
LUC7L3	tfdimers__MD00081	ETS2; OVOL2 (directAnnotation).
LUC7L3	transfac_pro__M06363	ZNF730 (directAnnotation).
LUC7L3	metacluster_23.6	ZNF440; ZSCAN26 (directAnnotation).
LUC7L3	transfac_pro__M05564	ZNF772 (directAnnotation).
LUC7L3	tfdimers__MD00482	POU5F1; RUNX3 (directAnnotation).
LUC7L3	metacluster_98.1	ZNF524 (directAnnotation).
LUC7L3	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
LUC7L3	transfac_pro__M05986	ZNF394 (inferredBy_Orthology).
LUC7L3	metacluster_90.4	ESR1; ESR1; ESRRA; ESRRA; ESRRA; ESRRA; ESRRA; ESRRA; ESRRA; ESRRA; ESRRB; ESRRB; ESRRB; ESRRB; ESRRG; ESRRG; ESRRG; ESRRG; ESRRG; NR5A1; NR5A1; NR5A1; NR5A2; NR5A2; NR5A2; NR5A2; NR5A2; NR5A2 (directAnnotation). AR; ESR1; ESR2; ESRRA; ESRRA; ESRRA; ESRRB; ESRRB; ESRRB; ESRRB; ESRRG; ESRRG; ESRRG; ESRRG; ESRRG; NR3C1; NR3C2; NR5A1; NR5A2; NR5A2; NR5A2; NR5A2; NR5A2; PGR; RXRG (inferredBy_Orthology).
LUC7L3	transfac_pro__M06751	ZNF510 (directAnnotation).
LUC7L3	metacluster_144.2	ZNF23 (directAnnotation).
LUC7L3	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
LUC7L3	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
LUC7L3	metacluster_182.10	ZFX (directAnnotation).
LUC7L3	transfac_pro__M06763	ZNF225 (directAnnotation).
LUC7L3	taipale_tf_pairs__ETV2_GSC2_RSCGGAANNNNNGGATTA_CAP_repr	ETV2; GSC2 (directAnnotation).
LUC7L3	cisbp__M08198	ELF1 (directAnnotation).
LUC7L3	transfac_pro__M01122	ZNF219 (directAnnotation).
LUC7L3	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
LUC7L3	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
LUC7L3	metacluster_84.2	RARA (directAnnotation).
LUC7L3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."