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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LTN1

Summary for LTN1

Gene information	Gene symbol	LTN1
	Ensembl ID	ENSG00000198862
	Entrez ID	26046
	Gene name	listerin E3 ubiquitin protein ligase 1
	Synonyms	C21orf10\|C21orf98\|FLJ11053\|KIAA0714\|LISTERIN\|RNF160\|ZNF294
	Gene type	protein_coding
	UniProtAcc	O94822

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Dataset with differentially expressed gene: LTN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.637546	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.267957	0.00e+00

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Expression of LTN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LTN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LTN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LTN1	hsa-miR-590-3p	99.6977	NM_001320766
LTN1	hsa-miR-520d-5p	98.9674	NM_001320766
LTN1	hsa-miR-524-5p	98.9674	NM_001320766
LTN1	hsa-miR-6833-3p	98.9341	NM_001320766
LTN1	hsa-miR-4768-5p	98.4406	NM_001320766
LTN1	hsa-miR-3671	97.7726	NM_001320766
LTN1	hsa-miR-5692a	96.7444	NM_001320766
LTN1	hsa-miR-4775	96.4083	NM_001320766
LTN1	hsa-miR-4282	96.298	NM_001320766
LTN1	hsa-miR-372-5p	95.6951	NM_001320766
LTN1	hsa-miR-5583-5p	95.0724	NM_001320766
LTN1	hsa-miR-3129-3p	95.0724	NM_001320766
LTN1	hsa-miR-12125	94.8916	NM_001320766
LTN1	hsa-miR-330-3p	92.605	NM_001320766
LTN1	hsa-miR-606	90.8446	NM_001320766
LTN1	hsa-miR-500a-5p	90.6715	NM_001320766
LTN1	hsa-miR-153-5p	90.6693	NM_001320766
LTN1	hsa-miR-193b-5p	89.2361	NM_001320766
LTN1	hsa-miR-548t-3p	89.2308	NM_001320766
LTN1	hsa-miR-548ap-3p	89.2308	NM_001320766
LTN1	hsa-miR-548aa	89.2308	NM_001320766
LTN1	hsa-miR-1277-5p	89.1118	NM_001320766
LTN1	hsa-miR-6855-5p	88.8245	NM_001320766
LTN1	hsa-miR-3123	88.4834	NM_001320766
LTN1	hsa-miR-380-3p	88.3313	NM_001320766
LTN1	hsa-miR-6882-5p	88.1926	NM_001320766
LTN1	hsa-miR-6512-5p	87.2202	NM_001320766
LTN1	hsa-miR-3170	87.0193	NM_001320766
LTN1	hsa-miR-544a	86.9305	NM_001320766
LTN1	hsa-miR-126-5p	85.9952	NM_001320766
LTN1	hsa-miR-335-3p	85.9431	NM_001320766
LTN1	hsa-miR-4795-3p	85.7963	NM_001320766
LTN1	hsa-miR-4470	85.5068	NM_001320766
LTN1	hsa-miR-2115-5p	84.6196	NM_001320766
LTN1	hsa-let-7b-3p	84.3324	NM_001320766
LTN1	hsa-let-7a-3p	84.3324	NM_001320766
LTN1	hsa-miR-98-3p	84.3324	NM_001320766
LTN1	hsa-let-7f-1-3p	84.3324	NM_001320766
LTN1	hsa-miR-8084	82.7597	NM_001320766
LTN1	hsa-miR-6809-3p	82.5469	NM_001320766
LTN1	hsa-miR-7154-5p	82.5005	NM_001320766
LTN1	hsa-miR-6873-3p	81.5052	NM_001320766
LTN1	hsa-miR-5692c	81.1055	NM_001320766
LTN1	hsa-miR-5692b	81.1055	NM_001320766

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Motifs and transcription factors (TFs) regulating LTN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LTN1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
LTN1	jaspar__MA1483.2	ELF2 (directAnnotation).
LTN1	hdpi__ETV4	ETV4 (directAnnotation).
LTN1	transfac_pro__M06071	ZNF814 (directAnnotation).
LTN1	transfac_pro__M04950	EGR1 (directAnnotation).
LTN1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
LTN1	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
LTN1	transfac_pro__M05427	ZNF516 (directAnnotation).
LTN1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."