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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LSM8

Summary for LSM8

Gene information	Gene symbol	LSM8
	Ensembl ID	ENSG00000128534
	Entrez ID	51691
	Gene name	LSM8 homolog, U6 small nuclear RNA associated
	Synonyms	YJR022W
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LSM8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.276831	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.413889	0.00e+00

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Expression of LSM8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LSM8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LSM8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LSM8	hsa-miR-32-3p	99.3645	NM_016200
LSM8	hsa-miR-4775	98.7413	NM_016200
LSM8	hsa-miR-590-3p	96.9118	NM_016200
LSM8	hsa-miR-4282	96.8409	NM_016200
LSM8	hsa-miR-5692a	96.4611	NM_016200
LSM8	hsa-miR-95-5p	95.4408	NM_016200
LSM8	hsa-miR-3163	94.7869	NM_016200
LSM8	hsa-miR-142-5p	92.4486	NM_016200
LSM8	hsa-miR-5590-3p	92.4486	NM_016200
LSM8	hsa-miR-4668-5p	92.276	NM_016200
LSM8	hsa-miR-494-3p	92.2609	NM_016200
LSM8	hsa-miR-219b-5p	92.1773	NM_016200
LSM8	hsa-miR-3074-3p	92.0618	NM_016200
LSM8	hsa-miR-548x-3p	91.2384	NM_016200
LSM8	hsa-miR-548aj-3p	91.2384	NM_016200
LSM8	hsa-miR-223-3p	90.9033	NM_016200
LSM8	hsa-miR-3686	90.7738	NM_016200
LSM8	hsa-miR-4753-3p	90.5073	NM_016200
LSM8	hsa-miR-607	90.2102	NM_016200
LSM8	hsa-miR-153-5p	90.1777	NM_016200
LSM8	hsa-miR-340-5p	90.123	NM_016200
LSM8	hsa-miR-6083	90.0645	NM_016200
LSM8	hsa-miR-4694-3p	89.8683	NM_016200
LSM8	hsa-miR-548av-5p	89.1407	NM_016200
LSM8	hsa-miR-548k	89.1407	NM_016200
LSM8	hsa-miR-3646	88.9705	NM_016200
LSM8	hsa-miR-548l	88.8269	NM_016200
LSM8	hsa-miR-4310	88.6432	NM_016200
LSM8	hsa-miR-3668	88.5655	NM_016200
LSM8	hsa-miR-593-3p	88.5068	NM_016200
LSM8	hsa-miR-4719	88.4094	NM_016200
LSM8	hsa-miR-4799-3p	88.3863	NM_016200
LSM8	hsa-miR-520d-5p	88.3585	NM_016200
LSM8	hsa-miR-524-5p	88.3585	NM_016200
LSM8	hsa-miR-6516-5p	88.0686	NM_016200
LSM8	hsa-miR-548aq-3p	87.3364	NM_016200
LSM8	hsa-miR-548ae-3p	87.3364	NM_016200
LSM8	hsa-miR-548j-3p	87.3364	NM_016200
LSM8	hsa-miR-2115-3p	87.0539	NM_016200
LSM8	hsa-miR-4720-5p	86.9881	NM_016200
LSM8	hsa-miR-5588-5p	86.878	NM_016200
LSM8	hsa-miR-548p	86.8668	NM_016200
LSM8	hsa-miR-587	86.771	NM_016200
LSM8	hsa-miR-548am-3p	86.48	NM_016200
LSM8	hsa-miR-548ah-3p	86.48	NM_016200
LSM8	hsa-miR-1285-5p	86.032	NM_016200
LSM8	hsa-miR-579-3p	85.4281	NM_016200
LSM8	hsa-miR-12136	85.2472	NM_016200
LSM8	hsa-miR-4698	85.1804	NM_016200
LSM8	hsa-miR-7157-5p	85.1064	NM_016200

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Motifs and transcription factors (TFs) regulating LSM8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LSM8	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
LSM8	swissregulon__hs__ETV6	ETV6 (directAnnotation).
LSM8	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
LSM8	jaspar__MA1483.2	ELF2 (directAnnotation).
LSM8	hdpi__TP73	TP73 (directAnnotation).
LSM8	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
LSM8	swissregulon__hs__ELF2	ELF2 (directAnnotation).
LSM8	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
LSM8	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
LSM8	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
LSM8	cisbp__M02645	ETS1 (directAnnotation).
LSM8	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
LSM8	hdpi__FLI1	FLI1 (directAnnotation).
LSM8	cisbp__M08198	ELF1 (directAnnotation).
LSM8	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
LSM8	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
LSM8	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
LSM8	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
LSM8	transfac_pro__M05697	ZNF235 (directAnnotation).
LSM8	hdpi__ETV4	ETV4 (directAnnotation).
LSM8	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
LSM8	jaspar__MA1933.1	SREBF2 (directAnnotation).
LSM8	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
LSM8	transfac_pro__M05711	ZNF37A (directAnnotation).
LSM8	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
LSM8	hdpi__HIP2	UBE2K (directAnnotation).
LSM8	hdpi__NRL	NRL (directAnnotation).
LSM8	transfac_pro__M00430	E2F1 (directAnnotation).
LSM8	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
LSM8	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
LSM8	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
LSM8	metacluster_7.13	ZFX (directAnnotation).
LSM8	jaspar__MA1122.1	TFDP1 (directAnnotation).
LSM8	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."