Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE138267 | CDX | Tumor tissue | Lung cancer | Small cell lung cancer (SCLC) | Chemotherapy | NA | NA | Malignant cells | -0.309687 | 0.00e+00 |
GSE131984_Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | NA | Malignant cells | 0.567703 | 0.00e+00 |
GSE163836 | FCIBC02 cell line | Cell line | Breast cancer | Inflammatory breast cancer | Chemotherapy | paclitaxel | NA | Malignant cells | -0.272229 | 0.00e+00 |
GSE153697 | patients | Bone marrow aspirate | Acute lymphoblastic leukemia | Relapsed B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | anti-CD19 CAR-T | NA | Malignant cells | 0.371936 | 5.31e-35 |
GSE152469 | patients | Peripheral blood mononuclear cells | Chronic lymphocytic leukemia | Chronic lymphocytic leukemia (CLL) | Targeted therapy | ibrutinib | NA | Malignant cells | -0.275316 | 0.00e+00 |
GSE131984_JQ1 | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 | NA | Malignant cells | -0.39306 | 6.65e-30 |
GSE131984_JQ1Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + paclitaxel | NA | Malignant cells | -0.622138 | 4.48e-44 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | -0.476435 | 1.92e-35 |
GSE131984_Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | palbociclib | NA | Malignant cells | -0.373515 | 5.98e-17 |
GSE164897_VemCob | A375 cell line | Cell line | Melanoma | BRAFV600E-mutant melanoma | Targeted therapy | vemurafenib + combimetinib | NA | Malignant cells | -0.59936 | 0.00e+00 |
GSE164897_VemTra | A375 cell line | Cell line | Melanoma | B+E2:E57RAFV600E-mutant melanoma | Targeted therapy | vemurafenib + trametinib | NA | Malignant cells | -0.408556 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
LSM10 | metacluster_70.16 | POU5F1; POU5F1 (directAnnotation). |
LSM10 | metacluster_34.4 | ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology). |
LSM10 | taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr | ETV2; HES7 (directAnnotation). |
LSM10 | taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1 | SPIB; TEAD4 (directAnnotation). |
LSM10 | transfac_pro__M06363 | ZNF730 (directAnnotation). |
LSM10 | taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_2 | SPIB; TEAD4 (directAnnotation). |
LSM10 | transfac_pro__M05924 | ZNF408 (directAnnotation). |
LSM10 | transfac_pro__M07480 | TEAD1 (directAnnotation). |
LSM10 | transfac_pro__M06240 | ZNF616 (directAnnotation). |
LSM10 | dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1 | GMEB2 (directAnnotation). |
LSM10 | transfac_pro__M06751 | ZNF510 (directAnnotation). |
LSM10 | dbtfbs__E2F8_representative_N1 | E2F8 (directAnnotation). |
LSM10 | jaspar__MA0693.3 | VDR (inferredBy_Orthology). |
LSM10 | metacluster_191.2 | ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology). |
LSM10 | swissregulon__hs__ELF2 | ELF2 (directAnnotation). |
LSM10 | hdpi__TP73 | TP73 (directAnnotation). |
LSM10 | transfac_pro__M04826 | EP300 (directAnnotation). |
LSM10 | metacluster_34.3 | EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation). |
LSM10 | hdpi__ETV4 | ETV4 (directAnnotation). |
LSM10 | metacluster_191.3 | EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology). |
LSM10 | metacluster_166.4 | BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology). |
LSM10 | metacluster_166.2 | ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology). |
LSM10 | metacluster_138.2 | ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology). |
LSM10 | taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP | ETV4; GCM1 (directAnnotation). |
LSM10 | taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr | ELK1; EOMES (directAnnotation). |
LSM10 | hdpi__ELF2 | ELF2 (directAnnotation). |
LSM10 | swissregulon__hs__ELK1 | ELK1 (directAnnotation). |
LSM10 | metacluster_183.4 | ETS1 (inferredBy_Orthology). |
LSM10 | taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth | ZNF385D (directAnnotation). |
LSM10 | transfac_pro__M00492 | STAT1 (directAnnotation). |
LSM10 | jaspar__MA0604.1 | ATF1 (inferredBy_Orthology). |
LSM10 | taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2 | ELK1; GCM1 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |