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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LRRC8C

Summary for LRRC8C

Gene information	Gene symbol	LRRC8C
	Ensembl ID	ENSG00000171488
	Entrez ID	84230
	Gene name	leucine rich repeat containing 8 VRAC subunit C
	Synonyms	AD158
	Gene type	protein_coding
	UniProtAcc	Q8TDW0

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Dataset with differentially expressed gene: LRRC8C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.266211	3.93e-14

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Expression of LRRC8C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LRRC8C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LRRC8C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LRRC8C	hsa-miR-5002-5p	99.3959	NM_032270
LRRC8C	hsa-miR-493-5p	96.4079	NM_032270
LRRC8C	hsa-miR-3148	95.8549	NM_032270
LRRC8C	hsa-miR-30c-5p	94.3814	NM_032270
LRRC8C	hsa-miR-30e-5p	94.3814	NM_032270
LRRC8C	hsa-miR-30d-5p	94.3814	NM_032270
LRRC8C	hsa-miR-30b-5p	94.3814	NM_032270
LRRC8C	hsa-miR-30a-5p	94.3814	NM_032270
LRRC8C	hsa-miR-4742-5p	94.2034	NM_032270
LRRC8C	hsa-miR-5582-3p	92.8311	NM_032270
LRRC8C	hsa-miR-3163	91.7824	NM_032270
LRRC8C	hsa-miR-10397-5p	91.599	NM_032270
LRRC8C	hsa-miR-3177-5p	90.0356	NM_032270
LRRC8C	hsa-miR-4742-3p	89.8281	NM_032270
LRRC8C	hsa-miR-6783-5p	89.3977	NM_032270
LRRC8C	hsa-miR-4743-3p	88.4995	NM_032270
LRRC8C	hsa-miR-6509-3p	88.4801	NM_032270
LRRC8C	hsa-miR-548an	88.0308	NM_032270
LRRC8C	hsa-miR-5010-3p	87.0438	NM_032270
LRRC8C	hsa-miR-570-3p	86.3479	NM_032270
LRRC8C	hsa-miR-664a-3p	86.0887	NM_032270
LRRC8C	hsa-miR-651-3p	86.0181	NM_032270
LRRC8C	hsa-miR-1236-5p	85.6912	NM_032270
LRRC8C	hsa-miR-6818-5p	85.6107	NM_032270
LRRC8C	hsa-miR-548ac	85.5546	NM_032270
LRRC8C	hsa-miR-548bb-3p	85.5546	NM_032270
LRRC8C	hsa-miR-548d-3p	85.5546	NM_032270
LRRC8C	hsa-miR-548z	85.5546	NM_032270
LRRC8C	hsa-miR-548h-3p	85.5546	NM_032270
LRRC8C	hsa-miR-1248	84.7829	NM_032270
LRRC8C	hsa-miR-3972	84.6986	NM_032270
LRRC8C	hsa-miR-1202	84.6986	NM_032270
LRRC8C	hsa-miR-4325	84.4741	NM_032270
LRRC8C	hsa-miR-498-5p	84.3223	NM_032270
LRRC8C	hsa-miR-3662	84.1989	NM_032270
LRRC8C	hsa-miR-499a-5p	83.4711	NM_032270
LRRC8C	hsa-miR-3910	82.8194	NM_032270
LRRC8C	hsa-miR-1290	82.4761	NM_032270
LRRC8C	hsa-miR-641	82.0408	NM_032270
LRRC8C	hsa-miR-3617-5p	82.0408	NM_032270
LRRC8C	hsa-miR-599	82.0117	NM_032270
LRRC8C	hsa-miR-3692-3p	81.2932	NM_032270
LRRC8C	hsa-miR-4650-3p	81.0312	NM_032270
LRRC8C	hsa-miR-891b	80.3909	NM_032270

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Motifs and transcription factors (TFs) regulating LRRC8C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LRRC8C	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
LRRC8C	transfac_pro__M01253	CNOT3 (directAnnotation).
LRRC8C	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
LRRC8C	transfac_pro__M02089	E2F3 (directAnnotation).
LRRC8C	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
LRRC8C	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LRRC8C	transfac_pro__M04916	TAF1 (directAnnotation).
LRRC8C	transfac_pro__M12697	ZNF142 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."