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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LRRC28

Summary for LRRC28

Gene information	Gene symbol	LRRC28
	Ensembl ID	ENSG00000168904
	Entrez ID	123355
	Gene name	leucine rich repeat containing 28
	Synonyms	FLJ34269\|FLJ45242\|MGC24976
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LRRC28

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-0.485427	4.62e-02

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Expression of LRRC28 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LRRC28

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LRRC28

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LRRC28	hsa-miR-605-3p	96.5707	NM_001284400
LRRC28	hsa-miR-1275	95.1128	NM_001321675
LRRC28	hsa-miR-3924	93.6347	NM_001321675
LRRC28	hsa-miR-6126	93.3926	NM_001321675
LRRC28	hsa-miR-4665-5p	93.1292	NM_001321675
LRRC28	hsa-miR-3167	92.4225	NM_001321675
LRRC28	hsa-miR-6868-5p	92.1933	NM_001284400
LRRC28	hsa-miR-876-5p	91.2734	NM_001321675
LRRC28	hsa-miR-548c-3p	90.5667	NM_001321675
LRRC28	hsa-miR-3180-5p	90.1798	NM_001321675
LRRC28	hsa-miR-5590-5p	88.3272	NM_001321675
LRRC28	hsa-miR-124-5p	87.5262	NM_001321675
LRRC28	hsa-miR-3613-3p	86.8325	NM_001321675
LRRC28	hsa-miR-4493	86.0879	NM_001284400
LRRC28	hsa-miR-96-5p	84.6249	NM_001284400
LRRC28	hsa-miR-4303	84.4513	NM_001321675
LRRC28	hsa-miR-6738-3p	83.8055	NM_001284400
LRRC28	hsa-miR-7111-5p	83.0476	NM_001321675
LRRC28	hsa-miR-6870-5p	83.0476	NM_001321675
LRRC28	hsa-miR-5698	83.0476	NM_001321675
LRRC28	hsa-miR-4723-5p	83.0476	NM_001321675
LRRC28	hsa-miR-302d-5p	81.8854	NM_001321675
LRRC28	hsa-miR-302b-5p	81.8854	NM_001321675
LRRC28	hsa-miR-519e-5p	81.8783	NM_001284400
LRRC28	hsa-miR-515-5p	81.8783	NM_001284400
LRRC28	hsa-miR-5582-3p	81.4175	NM_001321675
LRRC28	hsa-miR-1271-5p	81.3168	NM_001284400
LRRC28	hsa-miR-12133	81.3168	NM_001284400
LRRC28	hsa-miR-371b-5p	81.2262	NM_001321675
LRRC28	hsa-miR-373-5p	81.2262	NM_001321675
LRRC28	hsa-miR-616-5p	81.2262	NM_001321675
LRRC28	hsa-miR-7158-5p	80.7798	NM_001321675
LRRC28	hsa-miR-7160-5p	80.0776	NM_001321675

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Motifs and transcription factors (TFs) regulating LRRC28

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LRRC28	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNYAATTA_CAP	DLX3; ETV2 (directAnnotation).
LRRC28	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
LRRC28	transfac_pro__M07474	TBX20 (directAnnotation).
LRRC28	transfac_pro__M05625	ZFP2 (inferredBy_Orthology).
LRRC28	transfac_pro__M06146	ZNF45 (directAnnotation).
LRRC28	transfac_pro__M05690	ZNF20 (directAnnotation).
LRRC28	kznf__ZNF649_Imbeault2017_RP_RCADE	ZNF649 (directAnnotation).
LRRC28	transfac_pro__M05532	REST (inferredBy_Orthology).
LRRC28	taipale_tf_pairs__ETV2_PITX1_RSCGGAANNNNNGGMTTAN_CAP	ETV2; PITX1 (directAnnotation).
LRRC28	metacluster_117.1	GATA1; GATA1 (directAnnotation). GATA1; GATA1; GATA4; GATA4 (inferredBy_Orthology).
LRRC28	transfac_pro__M06451	ZNF614 (directAnnotation).
LRRC28	taipale_tf_pairs__ETV2_ONECUT2_RCCGGAANNNNNNRATCRATN_CAP_repr	ETV2; ONECUT2 (directAnnotation).
LRRC28	swissregulon__hs__CEBPB	CEBPB (directAnnotation).
LRRC28	taipale_tf_pairs__ETV2_DLX2_RCCGGAANNNNNYAATTA_CAP	DLX2; ETV2 (directAnnotation).
LRRC28	transfac_pro__M06045	ZNF729 (directAnnotation).
LRRC28	transfac_pro__M05737	ZNF699 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."