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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LRRC19

Summary for LRRC19

Gene information	Gene symbol	LRRC19
	Ensembl ID	ENSG00000184434
	Entrez ID	64922
	Gene name	leucine rich repeat containing 19
	Synonyms	FLJ21302
	Gene type	protein_coding
	UniProtAcc	Q9H756

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Dataset with differentially expressed gene: LRRC19

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.307846	5.69e-03

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Expression of LRRC19 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LRRC19

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LRRC19

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LRRC19	hsa-miR-205-3p	97.0689	NM_022901
LRRC19	hsa-miR-6755-3p	96.9639	NM_022901
LRRC19	hsa-miR-372-5p	93.7709	NM_022901
LRRC19	hsa-miR-7856-5p	92.2391	NM_022901
LRRC19	hsa-miR-7158-5p	91.6974	NM_022901
LRRC19	hsa-miR-4517	91.6525	NM_022901
LRRC19	hsa-miR-617	91.5259	NM_022901
LRRC19	hsa-miR-3613-3p	90.8929	NM_022901
LRRC19	hsa-miR-4521	90.0421	NM_022901
LRRC19	hsa-miR-379-3p	90.0386	NM_022901
LRRC19	hsa-miR-411-3p	90.0386	NM_022901
LRRC19	hsa-miR-889-3p	89.8818	NM_022901
LRRC19	hsa-miR-3145-3p	88.913	NM_022901
LRRC19	hsa-miR-218-5p	87.9361	NM_022901
LRRC19	hsa-miR-6844	86.3541	NM_022901
LRRC19	hsa-miR-548g-3p	85.4565	NM_022901
LRRC19	hsa-miR-26a-2-3p	85.2736	NM_022901
LRRC19	hsa-miR-6758-3p	84.9305	NM_022901
LRRC19	hsa-miR-12124	84.596	NM_022901
LRRC19	hsa-miR-374b-3p	84.3438	NM_022901
LRRC19	hsa-miR-4477b	84.2437	NM_022901
LRRC19	hsa-miR-6134	83.7151	NM_022901
LRRC19	hsa-miR-33a-5p	83.13	NM_022901
LRRC19	hsa-miR-33b-5p	83.13	NM_022901
LRRC19	hsa-miR-664b-3p	83.0623	NM_022901
LRRC19	hsa-miR-579-3p	83.0623	NM_022901
LRRC19	hsa-miR-494-3p	82.6979	NM_022901
LRRC19	hsa-miR-26a-1-3p	82.6807	NM_022901
LRRC19	hsa-miR-518c-5p	82.0303	NM_022901
LRRC19	hsa-miR-4699-5p	80.133	NM_022901
LRRC19	hsa-miR-373-5p	80.0749	NM_022901
LRRC19	hsa-miR-371b-5p	80.0749	NM_022901
LRRC19	hsa-miR-616-5p	80.0749	NM_022901

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Motifs and transcription factors (TFs) regulating LRRC19

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."