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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LRPAP1

Summary for LRPAP1

Gene information	Gene symbol	LRPAP1
	Ensembl ID	ENSG00000163956
	Entrez ID	4043
	Gene name	LDL receptor related protein associated protein 1
	Synonyms	A2MRAP\|HBP44\|RAP
	Gene type	protein_coding
	UniProtAcc	P30533

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Dataset with differentially expressed gene: LRPAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.281989	7.20e-15
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.317738	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	1.03319	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-1.07352	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.305323	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.564699	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.390518	0.00e+00

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Expression of LRPAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LRPAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LRPAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LRPAP1	hsa-miR-873-3p	96.8353	NM_002337
LRPAP1	hsa-miR-24-3p	96.5947	NM_002337
LRPAP1	hsa-miR-4294	96.153	NM_002337
LRPAP1	hsa-miR-377-3p	93.7705	NM_002337
LRPAP1	hsa-miR-4309	88.8308	NM_002337
LRPAP1	hsa-miR-4673	88.0519	NM_002337
LRPAP1	hsa-miR-3613-3p	87.8222	NM_002337
LRPAP1	hsa-miR-203a-3p	87.314	NM_002337
LRPAP1	hsa-miR-6799-5p	85.555	NM_002337
LRPAP1	hsa-miR-20a-5p	85.3681	NM_002337
LRPAP1	hsa-miR-106b-5p	85.3681	NM_002337
LRPAP1	hsa-miR-6819-3p	85.0856	NM_002337
LRPAP1	hsa-miR-6877-3p	85.0856	NM_002337
LRPAP1	hsa-miR-3198	84.7585	NM_002337
LRPAP1	hsa-miR-1289	83.9639	NM_002337
LRPAP1	hsa-miR-93-5p	83.6374	NM_002337
LRPAP1	hsa-miR-519d-3p	83.6374	NM_002337
LRPAP1	hsa-miR-17-5p	83.6374	NM_002337
LRPAP1	hsa-miR-20b-5p	83.6374	NM_002337
LRPAP1	hsa-miR-526b-3p	83.4934	NM_002337
LRPAP1	hsa-miR-106a-5p	83.3758	NM_002337
LRPAP1	hsa-miR-4645-5p	83.0847	NM_002337
LRPAP1	hsa-miR-558	82.323	NM_002337
LRPAP1	hsa-miR-616-5p	82.174	NM_002337
LRPAP1	hsa-miR-373-5p	82.174	NM_002337
LRPAP1	hsa-miR-371b-5p	82.174	NM_002337
LRPAP1	hsa-miR-570-3p	82.109	NM_002337
LRPAP1	hsa-miR-5690	81.929	NM_002337
LRPAP1	hsa-miR-766-3p	81.0469	NM_002337
LRPAP1	hsa-miR-6780a-5p	80.7264	NM_002337

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Motifs and transcription factors (TFs) regulating LRPAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LRPAP1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
LRPAP1	swissregulon__hs__CEBPB	CEBPB (directAnnotation).
LRPAP1	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
LRPAP1	metacluster_161.31	PRRX2 (directAnnotation).
LRPAP1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
LRPAP1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
LRPAP1	jaspar__MA1933.1	SREBF2 (directAnnotation).
LRPAP1	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."