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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LRP8

Summary for LRP8

Gene information	Gene symbol	LRP8
	Ensembl ID	ENSG00000157193
	Entrez ID	7804
	Gene name	LDL receptor related protein 8
	Synonyms	APOER2\|HSZ75190\|LRP-8\|MCI1
	Gene type	protein_coding
	UniProtAcc	Q14114

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Dataset with differentially expressed gene: LRP8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.384653	0.00e+00

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Expression of LRP8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LRP8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LRP8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LRP8	hsa-miR-5011-5p	99.9999	NM_001018054
LRP8	hsa-miR-190a-3p	99.9989	NM_001018054
LRP8	hsa-miR-8485	99.9215	NM_001018054
LRP8	hsa-miR-12136	98.2521	NM_001018054
LRP8	hsa-miR-593-3p	97.7793	NM_004631
LRP8	hsa-miR-5692a	97.411	NM_001018054
LRP8	hsa-miR-942-5p	97.3891	NM_004631
LRP8	hsa-miR-548l	95.5689	NM_001018054
LRP8	hsa-miR-2053	95.5634	NM_001018054
LRP8	hsa-miR-1277-5p	94.6061	NM_001018054
LRP8	hsa-miR-29a-5p	94.1572	NM_004631
LRP8	hsa-miR-3686	93.5842	NM_001018054
LRP8	hsa-miR-4699-3p	93.4427	NM_001018054
LRP8	hsa-miR-4684-5p	93.4408	NM_004631
LRP8	hsa-miR-4803	93.3501	NM_001018054
LRP8	hsa-miR-7110-3p	93.1428	NM_004631
LRP8	hsa-miR-454-3p	92.9077	NM_001018054
LRP8	hsa-miR-3121-5p	92.7095	NM_001018054
LRP8	hsa-miR-130a-3p	92.6235	NM_001018054
LRP8	hsa-miR-513c-3p	92.6201	NM_001018054
LRP8	hsa-miR-513a-3p	92.6201	NM_001018054
LRP8	hsa-miR-4295	92.3043	NM_001018054
LRP8	hsa-miR-130b-3p	92.3043	NM_001018054
LRP8	hsa-miR-3666	92.3043	NM_001018054
LRP8	hsa-miR-301b-3p	92.3043	NM_001018054
LRP8	hsa-miR-301a-3p	92.3043	NM_001018054
LRP8	hsa-miR-106b-5p	92.0013	NM_001018054
LRP8	hsa-miR-20a-5p	92.0013	NM_001018054
LRP8	hsa-miR-548n	91.8601	NM_001018054
LRP8	hsa-miR-449b-3p	91.298	NM_001018054
LRP8	hsa-miR-302e	90.8837	NM_001018054
LRP8	hsa-miR-106a-5p	90.5557	NM_001018054
LRP8	hsa-miR-526b-3p	90.5557	NM_001018054
LRP8	hsa-miR-3606-3p	90.2993	NM_001018054
LRP8	hsa-miR-93-5p	90.2103	NM_001018054
LRP8	hsa-miR-519d-3p	90.2103	NM_001018054
LRP8	hsa-miR-20b-5p	90.2103	NM_001018054
LRP8	hsa-miR-17-5p	90.2103	NM_001018054
LRP8	hsa-miR-4789-3p	89.0918	NM_001018054
LRP8	hsa-miR-578	88.5259	NM_004631
LRP8	hsa-miR-33b-3p	88.5045	NM_004631
LRP8	hsa-miR-519e-3p	88.4456	NM_004631
LRP8	hsa-miR-515-3p	88.4456	NM_004631
LRP8	hsa-miR-2467-5p	88.087	NM_004631
LRP8	hsa-miR-6508-5p	87.8231	NM_001018054
LRP8	hsa-miR-4643	87.6496	NM_001018054
LRP8	hsa-miR-4766-5p	87.5002	NM_004631
LRP8	hsa-miR-3148	87.4948	NM_001018054
LRP8	hsa-miR-372-3p	87.0124	NM_001018054
LRP8	hsa-miR-520a-3p	87.0124	NM_001018054

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Motifs and transcription factors (TFs) regulating LRP8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LRP8	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
LRP8	transfac_pro__M06071	ZNF814 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."