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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LRP12

Summary for LRP12

Gene information	Gene symbol	LRP12
	Ensembl ID	ENSG00000147650
	Entrez ID	29967
	Gene name	LDL receptor related protein 12
	Synonyms	FLJ12929\|ST7
	Gene type	protein_coding
	UniProtAcc	Q9Y561

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Dataset with differentially expressed gene: LRP12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.36181	0.00e+00

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Expression of LRP12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LRP12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LRP12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LRP12	hsa-miR-3529-3p	99.2085	NM_001135703
LRP12	hsa-miR-493-5p	98.8912	NM_001135703
LRP12	hsa-miR-548at-5p	98.3869	NM_001135703
LRP12	hsa-miR-3163	98.1748	NM_001135703
LRP12	hsa-miR-4775	97.5596	NM_013437
LRP12	hsa-let-7c-3p	97.4422	NM_001135703
LRP12	hsa-miR-561-3p	96.1528	NM_001135703
LRP12	hsa-miR-570-3p	95.9461	NM_013437
LRP12	hsa-miR-340-5p	94.8558	NM_001135703
LRP12	hsa-miR-5692a	94.3588	NM_001135703
LRP12	hsa-miR-302c-5p	92.3906	NM_013437
LRP12	hsa-miR-6772-3p	92.2626	NM_001135703
LRP12	hsa-miR-4329	92.0394	NM_001135703
LRP12	hsa-miR-4291	91.9331	NM_001135703
LRP12	hsa-miR-5007-3p	91.8033	NM_013437
LRP12	hsa-miR-4801	91.4589	NM_001135703
LRP12	hsa-miR-4645-3p	91.3574	NM_013437
LRP12	hsa-miR-3620-3p	91.357	NM_001135703
LRP12	hsa-miR-4685-3p	91.1857	NM_013437
LRP12	hsa-miR-4287	91.1857	NM_013437
LRP12	hsa-miR-520e-5p	91.1665	NM_013437
LRP12	hsa-miR-3660	90.7461	NM_013437
LRP12	hsa-miR-4526	90.7461	NM_013437
LRP12	hsa-miR-5700	90.1127	NM_013437
LRP12	hsa-miR-3121-3p	90.05	NM_001135703
LRP12	hsa-miR-153-3p	89.8998	NM_001135703
LRP12	hsa-miR-4731-3p	89.558	NM_001135703
LRP12	hsa-miR-769-5p	89.4496	NM_001135703
LRP12	hsa-miR-577	89.1954	NM_013437
LRP12	hsa-let-7g-3p	88.9859	NM_001135703
LRP12	hsa-let-7a-2-3p	88.9859	NM_001135703
LRP12	hsa-miR-7-2-3p	88.8977	NM_001135703
LRP12	hsa-miR-7-1-3p	88.8977	NM_001135703
LRP12	hsa-miR-545-3p	88.8538	NM_013437
LRP12	hsa-miR-548k	88.7233	NM_001135703
LRP12	hsa-miR-548av-5p	88.7233	NM_001135703
LRP12	hsa-miR-8054	88.7233	NM_001135703
LRP12	hsa-miR-186-5p	88.4322	NM_013437
LRP12	hsa-miR-5093	88.0352	NM_001135703
LRP12	hsa-miR-3688-3p	87.9574	NM_001135703
LRP12	hsa-miR-2054	87.4998	NM_001135703
LRP12	hsa-miR-524-5p	87.121	NM_001135703
LRP12	hsa-miR-520d-5p	87.121	NM_001135703
LRP12	hsa-miR-4671-3p	87.1113	NM_001135703
LRP12	hsa-miR-454-3p	86.6579	NM_001135703
LRP12	hsa-miR-153-5p	86.3664	NM_013437
LRP12	hsa-miR-143-3p	86.2713	NM_013437
LRP12	hsa-miR-6088	86.2713	NM_013437
LRP12	hsa-miR-4770	86.2713	NM_013437
LRP12	hsa-miR-4282	86.2299	NM_013437

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Motifs and transcription factors (TFs) regulating LRP12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LRP12	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
LRP12	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
LRP12	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
LRP12	transfac_pro__M04826	EP300 (directAnnotation).
LRP12	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
LRP12	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
LRP12	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
LRP12	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LRP12	transfac_pro__M00652	NRF1 (directAnnotation).
LRP12	hdpi__ETV4	ETV4 (directAnnotation).
LRP12	transfac_pro__M04866	HDAC2 (directAnnotation).
LRP12	jaspar__MA1122.1	TFDP1 (directAnnotation).
LRP12	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
LRP12	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."