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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LRP10

Summary for LRP10

Gene information	Gene symbol	LRP10
	Ensembl ID	ENSG00000197324
	Entrez ID	26020
	Gene name	LDL receptor related protein 10
	Synonyms	DKFZP564C1940\|LRP9\|MGC8675\|MST087\|MSTP087
	Gene type	protein_coding
	UniProtAcc	Q7Z4F1

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Dataset with differentially expressed gene: LRP10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.783951	2.03e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.285595	5.34e-16
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.259214	1.14e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.323753	1.50e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.301108	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.626711	0.00e+00

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Expression of LRP10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LRP10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LRP10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LRP10	hsa-miR-4717-5p	92.8341	NM_014045
LRP10	hsa-miR-4779	92.7073	NM_014045
LRP10	hsa-miR-145-3p	90.8871	NM_014045
LRP10	hsa-miR-6809-5p	90.3796	NM_014045
LRP10	hsa-miR-4753-5p	89.5552	NM_014045
LRP10	hsa-miR-1227-3p	82.9204	NM_014045
LRP10	hsa-miR-182-5p	81.7986	NM_014045
LRP10	hsa-miR-646	81.2635	NM_014045
LRP10	hsa-miR-6846-5p	80.2324	NM_014045
LRP10	hsa-miR-6848-5p	80.2324	NM_014045

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Motifs and transcription factors (TFs) regulating LRP10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LRP10	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
LRP10	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
LRP10	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
LRP10	transfac_pro__M07387	ZBTB7A (directAnnotation).
LRP10	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
LRP10	swissregulon__hs__CHD1	CHD1 (directAnnotation).
LRP10	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
LRP10	transfac_pro__M03876	ZBTB33 (directAnnotation).
LRP10	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
LRP10	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
LRP10	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LRP10	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LRP10	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LRP10	cisbp__M00968	MTF2 (directAnnotation).
LRP10	cisbp__M00341	PAX6 (directAnnotation).
LRP10	metacluster_198.3	ZFP64 (directAnnotation).
LRP10	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
LRP10	hdpi__ZNF304	ZNF304 (directAnnotation).
LRP10	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
LRP10	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
LRP10	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
LRP10	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LRP10	transfac_pro__M03806	ZBTB7C (directAnnotation).
LRP10	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LRP10	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
LRP10	metacluster_7.13	ZFX (directAnnotation).
LRP10	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
LRP10	taipale_tf_pairs__TEAD4_HOXA13_GGWATGNNNRTAAA_CAP_repr	HOXA13; TEAD4 (directAnnotation).
LRP10	taipale_tf_pairs__TEAD4_HOXB13_GGWATGNNNRTAAA_CAP	HOXB13; TEAD4 (directAnnotation).
LRP10	transfac_pro__M06084	ZNF208 (directAnnotation).
LRP10	transfac_pro__M05984	ZNF586 (directAnnotation).
LRP10	transfac_pro__M05718	ZNF30 (directAnnotation).
LRP10	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
LRP10	transfac_pro__M05769	ZNF48 (inferredBy_Orthology).
LRP10	taipale_cyt_meth__DMRTC2_GAACGATACA_FL	DMRTC2 (directAnnotation).
LRP10	taipale_tf_pairs__MEIS2_ONECUT2_NTGACAGNTAATCRATAN_HT	MEIS2; ONECUT2 (directAnnotation).
LRP10	c2h2_zfs__M0373	ZSCAN26 (inferredBy_Orthology).
LRP10	metacluster_188.9	FOXJ3 (directAnnotation). FOXJ3 (inferredBy_Orthology).
LRP10	kznf__ZNF181_Imbeault2017_OM_RCADE	ZNF181 (directAnnotation).
LRP10	transfac_pro__M07448	ZBED1 (directAnnotation).
LRP10	transfac_pro__M06715	ZNF331 (directAnnotation).
LRP10	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
LRP10	metacluster_172.27	DMRTC2 (directAnnotation).
LRP10	transfac_pro__M06585	ZNF479 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."