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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LPXN

Summary for LPXN

Gene information	Gene symbol	LPXN
	Ensembl ID	ENSG00000110031
	Entrez ID	9404
	Gene name	leupaxin
	Synonyms	LDPL
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LPXN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.58236	5.50e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.277555	3.88e-40
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.815338	9.63e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-1.05606	0.00e+00

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Expression of LPXN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LPXN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LPXN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LPXN	hsa-miR-4516	91.9767	NM_001307951
LPXN	hsa-miR-4434	86.7041	NM_001307951
LPXN	hsa-miR-5703	86.7041	NM_001307951
LPXN	hsa-miR-194-5p	82.6043	NM_001307951
LPXN	hsa-miR-7111-3p	81.4995	NM_001307951
LPXN	hsa-miR-4668-5p	81.465	NM_001307951
LPXN	hsa-miR-6127	80.2567	NM_001307951
LPXN	hsa-miR-6130	80.2567	NM_001307951
LPXN	hsa-miR-6129	80.2567	NM_001307951
LPXN	hsa-miR-4510	80.2567	NM_001307951
LPXN	hsa-miR-6133	80.2567	NM_001307951

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Motifs and transcription factors (TFs) regulating LPXN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LPXN	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
LPXN	jaspar__MA1483.2	ELF2 (directAnnotation).
LPXN	hdpi__ETV4	ETV4 (directAnnotation).
LPXN	transfac_pro__M06806	PEG3 (directAnnotation).
LPXN	tfdimers__MD00165	CRX; FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND (directAnnotation).
LPXN	cisbp__M00767	ZSCAN10 (inferredBy_Orthology).
LPXN	transfac_public__M00271	RUNX1 (directAnnotation).
LPXN	transfac_pro__M06251	ZSCAN2 (inferredBy_Orthology).
LPXN	jaspar__MA1952.1	FOXJ2 (directAnnotation).
LPXN	jaspar__MA0776.1	MYBL1 (directAnnotation).
LPXN	tfdimers__MD00138	IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; MYB (directAnnotation).
LPXN	metacluster_141.2	E2F2; E2F3 (directAnnotation).
LPXN	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
LPXN	swissregulon__mm__Elf3	ELF3 (inferredBy_Orthology).
LPXN	kznf__ZNF555_Imbeault2017_RP_ChIP-seq	ZNF555 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."