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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LIPA

Summary for LIPA

Gene information	Gene symbol	LIPA
	Ensembl ID	ENSG00000107798
	Entrez ID	3988
	Gene name	lipase A, lysosomal acid type
	Synonyms	CESD\|LAL
	Gene type	protein_coding
	UniProtAcc	P38571

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Dataset with differentially expressed gene: LIPA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.992491	1.56e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.275854	7.68e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.268211	2.11e-04
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.558476	7.01e-18
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.853925	1.99e-08
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.298528	2.82e-13
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	Malignant cells	0.321434	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	0.336699	0.00e+00

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Expression of LIPA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LIPA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LIPA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LIPA	hsa-miR-1250-3p	95.0647	NM_001127605
LIPA	hsa-miR-148b-3p	94.7617	NM_001127605
LIPA	hsa-miR-148a-3p	94.7617	NM_001127605
LIPA	hsa-miR-152-3p	94.7617	NM_001127605
LIPA	hsa-miR-4319	94.7447	NM_000235
LIPA	hsa-miR-125a-5p	94.5046	NM_000235
LIPA	hsa-miR-125b-5p	94.5046	NM_000235
LIPA	hsa-miR-8087	93.7934	NM_001127605
LIPA	hsa-miR-4464	91.7664	NM_001127605
LIPA	hsa-miR-4748	91.7664	NM_001127605
LIPA	hsa-miR-3145-3p	90.1442	NM_001127605
LIPA	hsa-miR-578	90.0616	NM_001127605
LIPA	hsa-miR-499a-5p	89.8537	NM_001127605
LIPA	hsa-miR-4701-3p	89.2235	NM_001127605
LIPA	hsa-miR-6736-5p	89.2235	NM_001127605
LIPA	hsa-miR-1262	89.2235	NM_001127605
LIPA	hsa-miR-3153	87.6587	NM_001127605
LIPA	hsa-miR-524-5p	87.1839	NM_001127605
LIPA	hsa-miR-520d-5p	87.1839	NM_001127605
LIPA	hsa-miR-6739-5p	86.8178	NM_001127605
LIPA	hsa-miR-6733-5p	86.8178	NM_001127605
LIPA	hsa-miR-10524-5p	86.2791	NM_001127605
LIPA	hsa-miR-12122	85.9375	NM_001127605
LIPA	hsa-miR-5190	83.7833	NM_001127605
LIPA	hsa-miR-3184-3p	83.6229	NM_000235
LIPA	hsa-miR-570-3p	82.6943	NM_001127605
LIPA	hsa-miR-2355-3p	82.4582	NM_001127605
LIPA	hsa-miR-4789-3p	81.1586	NM_001127605
LIPA	hsa-miR-3074-3p	80.1323	NM_001127605

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Motifs and transcription factors (TFs) regulating LIPA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LIPA	hdpi__HIP2	UBE2K (directAnnotation).
LIPA	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
LIPA	metacluster_22.37	BACH1 (directAnnotation).
LIPA	metacluster_22.11	NFE2 (directAnnotation).
LIPA	metacluster_22.33	MAFK (inferredBy_Orthology).
LIPA	metacluster_22.39	NFE2L2 (directAnnotation).
LIPA	transfac_pro__M05807	ZNF628 (inferredBy_Orthology).
LIPA	nitta__Ets98B_TTCCCC20NTA_KH_TKGCGGATGCN_m1_c3	SPDEF (inferredBy_Orthology).
LIPA	metacluster_144.10	ZNF100 (directAnnotation).
LIPA	transfac_pro__M05670	ZNF37A (directAnnotation).
LIPA	nitta__Rfx_TGTGAA40NTAC_KK_GTTGCNNNNNGCAAC_m2_c2	RFX1; RFX2; RFX3; RFX4; RFX6; RFX8 (inferredBy_Orthology).
LIPA	taipale__VENTX_DBD_SSYTAATCGRWAANCGATTAR_repr	VENTX (directAnnotation).
LIPA	transfac_pro__M06429	ZSCAN2 (directAnnotation).
LIPA	transfac_pro__M06251	ZSCAN2 (inferredBy_Orthology).
LIPA	transfac_pro__M06394	ZNF761 (directAnnotation).
LIPA	kznf__ZNF25_Imbeault2017_RP_ChIP-seq	ZNF25 (directAnnotation).
LIPA	taipale_tf_pairs__FLI1_CEBPD_RNCGGANNTTGCGCAAN_CAP	CEBPD; FLI1 (directAnnotation).
LIPA	taipale_tf_pairs__MGA_PITX1_RGGTGNTAAKCCN_CAP_repr	MGA; PITX1 (directAnnotation).
LIPA	transfac_pro__M06349	ZNF629 (inferredBy_Orthology).
LIPA	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
LIPA	dbtfbs__ZNF610_HEK293_ENCSR691TXI_merged_N1	ZNF610 (directAnnotation).
LIPA	taipale_cyt_meth__ELF3_NTGTGCGGATGCN_FL_repr	ELF3 (directAnnotation).
LIPA	metacluster_141.10	THAP1; THAP1; THAP1 (directAnnotation).
LIPA	hocomoco__HSF1_MOUSE.H11MO.1.A	HSF1 (inferredBy_Orthology).
LIPA	metacluster_167.7	IRF8 (inferredBy_Orthology).
LIPA	tfdimers__MD00056	EP300; ZEB1 (directAnnotation).
LIPA	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
LIPA	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
LIPA	transfac_pro__M05985	ZNF394 (inferredBy_Orthology).
LIPA	metacluster_103.2	ZNF136; ZNF680 (directAnnotation).
LIPA	tfdimers__MD00409	ETS1; YY2 (directAnnotation).
LIPA	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
LIPA	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
LIPA	metacluster_167.5	EHF; ELF5; NFATC3; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIC; SPIC; STAT5A (directAnnotation). ETS1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIC (inferredBy_Orthology).
LIPA	transfac_pro__M05935	ZNF382 (directAnnotation).
LIPA	tfdimers__MD00158	DBP; ZNF354C (directAnnotation).
LIPA	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRWMAACAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
LIPA	kznf__CTCF_Rhee2011.3_ChIP-exo	CTCF (directAnnotation).
LIPA	transfac_pro__M06504	ZFP62 (directAnnotation).
LIPA	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
LIPA	homer__ATTGCGCAAC_CEBP	CEBPB (inferredBy_Orthology).
LIPA	tfdimers__MD00208	IRF1; LTF (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."