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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LIN7C

Summary for LIN7C

Gene information	Gene symbol	LIN7C
	Ensembl ID	ENSG00000148943
	Entrez ID	55327
	Gene name	lin-7 homolog C, crumbs cell polarity complex component
	Synonyms	FLJ11215\|LIN-7-C\|LIN-7C\|MALS-3\|VELI3
	Gene type	protein_coding
	UniProtAcc	Q9NUP9

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Dataset with differentially expressed gene: LIN7C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.276525	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.270407	3.10e-23

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Expression of LIN7C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LIN7C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LIN7C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LIN7C	hsa-miR-3646	99.9879	NM_018362
LIN7C	hsa-miR-548c-3p	99.4439	NM_018362
LIN7C	hsa-miR-190a-3p	99.4139	NM_018362
LIN7C	hsa-miR-10527-5p	99.064	NM_018362
LIN7C	hsa-miR-5011-5p	98.8366	NM_018362
LIN7C	hsa-miR-199a-5p	97.9137	NM_018362
LIN7C	hsa-miR-199b-5p	97.9137	NM_018362
LIN7C	hsa-miR-3662	97.5645	NM_018362
LIN7C	hsa-miR-548n	96.9932	NM_018362
LIN7C	hsa-miR-22-3p	96.3176	NM_018362
LIN7C	hsa-miR-1468-3p	95.9584	NM_018362
LIN7C	hsa-miR-4659b-3p	94.9225	NM_018362
LIN7C	hsa-miR-4659a-3p	94.9225	NM_018362
LIN7C	hsa-miR-7156-3p	94.8858	NM_018362
LIN7C	hsa-miR-3613-3p	94.6753	NM_018362
LIN7C	hsa-miR-3163	93.2341	NM_018362
LIN7C	hsa-miR-548e-5p	93.192	NM_018362
LIN7C	hsa-miR-302b-5p	92.8966	NM_018362
LIN7C	hsa-miR-302d-5p	92.8966	NM_018362
LIN7C	hsa-miR-7849-3p	92.7015	NM_018362
LIN7C	hsa-miR-4477a	92.005	NM_018362
LIN7C	hsa-miR-372-5p	91.9124	NM_018362
LIN7C	hsa-miR-3908	91.6853	NM_018362
LIN7C	hsa-miR-8054	91.5053	NM_018362
LIN7C	hsa-miR-548k	91.5053	NM_018362
LIN7C	hsa-miR-548av-5p	91.5053	NM_018362
LIN7C	hsa-miR-4698	90.3509	NM_018362
LIN7C	hsa-miR-1252-3p	89.8376	NM_018362
LIN7C	hsa-miR-3059-3p	89.7497	NM_018362
LIN7C	hsa-miR-3680-3p	89.2129	NM_018362
LIN7C	hsa-miR-3658	89.1557	NM_018362
LIN7C	hsa-miR-3145-3p	89.0748	NM_018362
LIN7C	hsa-miR-6507-5p	89.054	NM_018362
LIN7C	hsa-miR-433-3p	88.0738	NM_018362
LIN7C	hsa-miR-4445-5p	87.9198	NM_018362
LIN7C	hsa-miR-889-3p	87.3591	NM_018362
LIN7C	hsa-miR-506-5p	86.2898	NM_018362
LIN7C	hsa-miR-19b-1-5p	85.7947	NM_018362
LIN7C	hsa-miR-19b-2-5p	85.7947	NM_018362
LIN7C	hsa-miR-19a-5p	85.7947	NM_018362
LIN7C	hsa-miR-548aj-3p	85.3806	NM_018362
LIN7C	hsa-miR-548x-3p	85.3806	NM_018362
LIN7C	hsa-miR-590-3p	84.6453	NM_018362
LIN7C	hsa-miR-3927-5p	84.4638	NM_018362
LIN7C	hsa-miR-194-5p	84.448	NM_018362
LIN7C	hsa-miR-1825	84.3306	NM_018362
LIN7C	hsa-miR-124-5p	84.3288	NM_018362
LIN7C	hsa-miR-513a-5p	84.3263	NM_018362
LIN7C	hsa-miR-6848-3p	84.0563	NM_018362
LIN7C	hsa-miR-6843-3p	84.0563	NM_018362

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Motifs and transcription factors (TFs) regulating LIN7C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LIN7C	metacluster_7.13	ZFX (directAnnotation).
LIN7C	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LIN7C	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
LIN7C	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
LIN7C	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."