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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LIN7A

Summary for LIN7A

Gene information	Gene symbol	LIN7A
	Ensembl ID	ENSG00000111052
	Entrez ID	8825
	Gene name	lin-7 homolog A, crumbs cell polarity complex component
	Synonyms	LIN-7A\|MALS-1\|TIP-33\|VELI1
	Gene type	protein_coding
	UniProtAcc	O14910

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Dataset with differentially expressed gene: LIN7A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.96904	1.49e-06
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.447604	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.634806	0.00e+00

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Expression of LIN7A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LIN7A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LIN7A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LIN7A	hsa-miR-1277-5p	99.9185	NM_004664
LIN7A	hsa-miR-3163	99.5234	NM_004664
LIN7A	hsa-miR-4261	99.1637	NM_001324423
LIN7A	hsa-miR-147b-5p	98.2609	NM_001324423
LIN7A	hsa-miR-7855-5p	97.3949	NM_001324423
LIN7A	hsa-miR-369-3p	96.3195	NM_001324423
LIN7A	hsa-miR-4328	96.2374	NM_001324423
LIN7A	hsa-miR-570-3p	95.9589	NM_004664
LIN7A	hsa-miR-5692c	95.7605	NM_004664
LIN7A	hsa-miR-5692b	95.7605	NM_004664
LIN7A	hsa-miR-3133	95.6678	NM_004664
LIN7A	hsa-miR-190a-3p	94.3239	NM_001324423
LIN7A	hsa-miR-29a-3p	93.6831	NM_004664
LIN7A	hsa-miR-29c-3p	93.6831	NM_004664
LIN7A	hsa-miR-29b-3p	93.6831	NM_004664
LIN7A	hsa-miR-3646	93.477	NM_001324423
LIN7A	hsa-miR-653-5p	93.4696	NM_001324423
LIN7A	hsa-miR-4282	92.3692	NM_001324423
LIN7A	hsa-miR-203a-3p	91.6508	NM_001324423
LIN7A	hsa-miR-892a	91.5489	NM_004664
LIN7A	hsa-miR-8063	91.4088	NM_004664
LIN7A	hsa-miR-519d-5p	91.0519	NM_001324423
LIN7A	hsa-miR-548aj-3p	90.8971	NM_004664
LIN7A	hsa-miR-548x-3p	90.8971	NM_004664
LIN7A	hsa-miR-5700	90.7793	NM_001324423
LIN7A	hsa-miR-758-3p	90.4629	NM_001324423
LIN7A	hsa-miR-607	89.357	NM_004664
LIN7A	hsa-miR-548ah-3p	89.2139	NM_004664
LIN7A	hsa-miR-548am-3p	89.2139	NM_004664
LIN7A	hsa-miR-2053	89.0657	NM_001324423
LIN7A	hsa-miR-4495	89.0211	NM_004664
LIN7A	hsa-miR-6864-5p	88.761	NM_001324423
LIN7A	hsa-miR-383-3p	88.5653	NM_001324423
LIN7A	hsa-miR-4307	87.889	NM_001324423
LIN7A	hsa-miR-548j-3p	87.6461	NM_004664
LIN7A	hsa-miR-548aq-3p	87.6461	NM_004664
LIN7A	hsa-miR-548ae-3p	87.6461	NM_004664
LIN7A	hsa-miR-6124	87.4378	NM_004664
LIN7A	hsa-miR-410-3p	87.0666	NM_001324423
LIN7A	hsa-miR-3662	86.5667	NM_001324423
LIN7A	hsa-miR-5011-5p	86.4726	NM_001324423
LIN7A	hsa-miR-186-5p	86.2437	NM_004664
LIN7A	hsa-miR-5582-3p	86.024	NM_004664
LIN7A	hsa-miR-7162-5p	85.9292	NM_001324423
LIN7A	hsa-miR-516b-3p	85.9292	NM_001324423
LIN7A	hsa-miR-516a-3p	85.9292	NM_001324423
LIN7A	hsa-miR-3915	85.7878	NM_001324423
LIN7A	hsa-miR-203b-3p	85.7216	NM_001324423
LIN7A	hsa-miR-4517	85.3892	NM_001324423
LIN7A	hsa-miR-559	84.7211	NM_001324423

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Motifs and transcription factors (TFs) regulating LIN7A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LIN7A	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
LIN7A	hdpi__ETV4	ETV4 (directAnnotation).
LIN7A	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
LIN7A	transfac_pro__M06156	ZNF75D (directAnnotation).
LIN7A	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
LIN7A	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
LIN7A	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
LIN7A	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
LIN7A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LIN7A	transfac_pro__M04950	EGR1 (directAnnotation).
LIN7A	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."