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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: LIMK2

Summary for LIMK2

Gene information	Gene symbol	LIMK2
	Ensembl ID	ENSG00000182541
	Entrez ID	3985
	Gene name	LIM domain kinase 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LIMK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.369707	1.99e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.475744	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.328707	0.00e+00

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Expression of LIMK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LIMK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LIMK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LIMK2	hsa-miR-5011-5p	98.26	NM_001031801
LIMK2	hsa-miR-1324	94.3982	NM_005569
LIMK2	hsa-miR-6799-5p	92.9066	NM_005569
LIMK2	hsa-miR-6852-5p	92.726	NM_005569
LIMK2	hsa-miR-190a-3p	92.589	NM_001031801
LIMK2	hsa-miR-3925-3p	89.911	NM_005569
LIMK2	hsa-miR-5580-5p	89.8637	NM_005569
LIMK2	hsa-miR-4731-5p	87.1335	NM_005569
LIMK2	hsa-miR-4796-3p	85.3455	NM_001031801
LIMK2	hsa-miR-4668-3p	82.0625	NM_001031801
LIMK2	hsa-miR-32-3p	80.8946	NM_016733
LIMK2	hsa-miR-6825-5p	80.4353	NM_005569
LIMK2	hsa-miR-6882-3p	80.3476	NM_005569
LIMK2	hsa-miR-12120	80.3387	NM_001031801
LIMK2	hsa-miR-6500-5p	80.1343	NM_005569
LIMK2	hsa-miR-4633-3p	80.1343	NM_005569

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Motifs and transcription factors (TFs) regulating LIMK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LIMK2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
LIMK2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
LIMK2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
LIMK2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
LIMK2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
LIMK2	homer__TTCCKNAGAA_STAT6	STAT6 (inferredBy_Orthology).
LIMK2	transfac_pro__M01239	RELA (directAnnotation).
LIMK2	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).
LIMK2	metacluster_187.8	ZNF22 (directAnnotation).
LIMK2	kznf__ZNF124_Imbeault2017_RP_RCADE	ZNF124 (directAnnotation).
LIMK2	metacluster_38.3	STAT6; STAT6 (directAnnotation). STAT6; STAT6 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
LIMK2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."