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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LIMCH1

Summary for LIMCH1

Gene information	Gene symbol	LIMCH1
	Ensembl ID	ENSG00000064042
	Entrez ID	22998
	Gene name	LIM and calponin homology domains 1
	Synonyms	DKFZP686A01247\|LIMCH1A\|LMO7B
	Gene type	protein_coding
	UniProtAcc	Q9UPQ0

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Dataset with differentially expressed gene: LIMCH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.03836	3.69e-07
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.451424	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.0919	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.424985	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.502251	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.539065	0.00e+00

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Expression of LIMCH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LIMCH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LIMCH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LIMCH1	hsa-miR-7705	98.6856	NM_001112717
LIMCH1	hsa-miR-30b-5p	98.1127	NM_001112717
LIMCH1	hsa-miR-30e-5p	98.1127	NM_001112717
LIMCH1	hsa-miR-30a-5p	98.1127	NM_001112717
LIMCH1	hsa-miR-30c-5p	98.1127	NM_001112717
LIMCH1	hsa-miR-30d-5p	98.1127	NM_001112717
LIMCH1	hsa-miR-3686	97.4898	NM_001112717
LIMCH1	hsa-miR-137-3p	97.1428	NM_001112717
LIMCH1	hsa-miR-551b-5p	96.9257	NM_001112717
LIMCH1	hsa-miR-6854-5p	96.7749	NM_001112717
LIMCH1	hsa-miR-3646	95.0814	NM_014988
LIMCH1	hsa-miR-3714	94.0174	NM_001112717
LIMCH1	hsa-miR-144-3p	93.6143	NM_014988
LIMCH1	hsa-miR-6853-3p	93.3912	NM_014988
LIMCH1	hsa-miR-493-5p	93.2863	NM_001112717
LIMCH1	hsa-miR-506-3p	92.9836	NM_001112717
LIMCH1	hsa-miR-124-3p	92.9836	NM_001112717
LIMCH1	hsa-miR-5582-5p	92.6647	NM_001112717
LIMCH1	hsa-miR-3148	92.154	NM_001112717
LIMCH1	hsa-miR-19b-3p	91.8894	NM_001112717
LIMCH1	hsa-miR-19a-3p	91.8894	NM_001112717
LIMCH1	hsa-miR-548aa	90.7213	NM_014988
LIMCH1	hsa-miR-548ap-3p	90.7213	NM_014988
LIMCH1	hsa-miR-548t-3p	90.7213	NM_014988
LIMCH1	hsa-miR-4262	90.4631	NM_001112717
LIMCH1	hsa-miR-7853-5p	90.2745	NM_001112717
LIMCH1	hsa-miR-105-5p	90.2745	NM_001112717
LIMCH1	hsa-miR-6511a-5p	89.4446	NM_001112717
LIMCH1	hsa-miR-1910-3p	89.4446	NM_001112717
LIMCH1	hsa-miR-6737-3p	89.1272	NM_014988
LIMCH1	hsa-miR-7157-3p	89.1272	NM_014988
LIMCH1	hsa-miR-4534	88.7924	NM_014988
LIMCH1	hsa-miR-4698	88.7083	NM_001112717
LIMCH1	hsa-miR-181a-5p	88.6232	NM_001112717
LIMCH1	hsa-miR-181c-5p	88.6232	NM_001112717
LIMCH1	hsa-miR-181d-5p	88.6232	NM_001112717
LIMCH1	hsa-miR-181b-5p	88.6232	NM_001112717
LIMCH1	hsa-miR-12136	88.4521	NM_001112717
LIMCH1	hsa-miR-660-5p	87.9957	NM_014988
LIMCH1	hsa-miR-8063	87.5041	NM_001112717
LIMCH1	hsa-miR-548aw	87.3623	NM_014988
LIMCH1	hsa-miR-5008-3p	87.0949	NM_014988
LIMCH1	hsa-miR-4803	86.7406	NM_001112717
LIMCH1	hsa-miR-138-5p	85.5235	NM_001112717
LIMCH1	hsa-miR-367-3p	85.476	NM_001112717
LIMCH1	hsa-miR-32-5p	85.4335	NM_001112717
LIMCH1	hsa-miR-92b-3p	85.4335	NM_001112717
LIMCH1	hsa-miR-92a-3p	85.4335	NM_001112717
LIMCH1	hsa-miR-548at-5p	84.6416	NM_001112717
LIMCH1	hsa-miR-8082	83.9491	NM_014988

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Motifs and transcription factors (TFs) regulating LIMCH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LIMCH1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
LIMCH1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
LIMCH1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
LIMCH1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
LIMCH1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
LIMCH1	hdpi__ETV4	ETV4 (directAnnotation).
LIMCH1	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
LIMCH1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
LIMCH1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
LIMCH1	jaspar__MA1483.2	ELF2 (directAnnotation).
LIMCH1	cisbp__M00808	MYPOP (inferredBy_Orthology).
LIMCH1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
LIMCH1	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
LIMCH1	cisbp__M08198	ELF1 (directAnnotation).
LIMCH1	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
LIMCH1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
LIMCH1	transfac_pro__M02843	BBX (inferredBy_Orthology).
LIMCH1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
LIMCH1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
LIMCH1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
LIMCH1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
LIMCH1	transfac_pro__M07387	ZBTB7A (directAnnotation).
LIMCH1	transfac_pro__M00716	ZBTB14 (directAnnotation).
LIMCH1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
LIMCH1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
LIMCH1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
LIMCH1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
LIMCH1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
LIMCH1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
LIMCH1	transfac_pro__M02089	E2F3 (directAnnotation).
LIMCH1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
LIMCH1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
LIMCH1	transfac_pro__M01175	ZBTB7B (directAnnotation).
LIMCH1	cisbp__M00249	WT1 (directAnnotation).
LIMCH1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
LIMCH1	transfac_pro__M01303	SP1 (directAnnotation).
LIMCH1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LIMCH1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LIMCH1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LIMCH1	cisbp__M00968	MTF2 (directAnnotation).
LIMCH1	cisbp__M00341	PAX6 (directAnnotation).
LIMCH1	metacluster_198.3	ZFP64 (directAnnotation).
LIMCH1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
LIMCH1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
LIMCH1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
LIMCH1	metacluster_151.2	ZNF23 (directAnnotation).
LIMCH1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
LIMCH1	transfac_pro__M04817	ZBTB33 (directAnnotation).
LIMCH1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
LIMCH1	tfdimers__MD00483	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."