Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LILRB4

Summary for LILRB4

Gene information	Gene symbol	LILRB4
	Ensembl ID	ENSG00000278555
	Entrez ID	11006
	Gene name	leukocyte immunoglobulin like receptor B4
	Synonyms	CD85k\|HM18\|ILT3\|LIR-5\|LIR5
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: LILRB4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.469577	1.07e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	0.701092	1.43e-03
GSE212217	patients	Peripheral blood mononuclear cells	Endometrial cancer	Epigenetic MMRd endometrial carcinoma	Immunotherapy	pembrolizumab	pre	Plasma cells	0.553658	9.76e-04
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	1.04028	1.01e-33
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.514455	2.52e-14
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	post	Malignant cells	0.391486	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	pre	Malignant cells	0.564978	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.688434	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.920136	0.00e+00

Top

Expression of LILRB4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to LILRB4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating LILRB4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LILRB4	hsa-miR-4527	95.4045	NM_001278428
LILRB4	hsa-miR-6867-5p	94.5258	NM_001278428
LILRB4	hsa-miR-6503-5p	93.2703	NM_001278428
LILRB4	hsa-miR-2053	93.1982	NM_001278428
LILRB4	hsa-miR-1266-5p	86.5218	NM_001278428
LILRB4	hsa-miR-4518	86.5218	NM_001278428
LILRB4	hsa-miR-2276-3p	85.0416	NM_001278428
LILRB4	hsa-miR-6878-5p	84.0154	NM_001278428
LILRB4	hsa-miR-6853-3p	83.5705	NM_001278428
LILRB4	hsa-miR-4652-3p	83.1658	NM_001278428
LILRB4	hsa-miR-153-5p	82.7273	NM_001278428
LILRB4	hsa-miR-486-5p	81.9379	NM_001278428
LILRB4	hsa-miR-6829-3p	81.478	NM_001278428
LILRB4	hsa-miR-6791-3p	81.478	NM_001278428
LILRB4	hsa-miR-4289	81.2951	NM_001278428

Page: 1

Top

Motifs and transcription factors (TFs) regulating LILRB4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LILRB4	taipale_tf_pairs__ELK1_PAX5_RSCGGAACYACGCWYSANTG_CAP_repr	ELK1; PAX5 (directAnnotation).
LILRB4	metacluster_167.7	IRF8 (inferredBy_Orthology).
LILRB4	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
LILRB4	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_HT	HOXB13; ONECUT2 (directAnnotation).
LILRB4	transfac_pro__M06372	ZNF841 (directAnnotation).
LILRB4	taipale_tf_pairs__GCM1_FOXO1_RTMAATAMGGGYRN_CAP	FOXO1; GCM1 (directAnnotation).
LILRB4	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
LILRB4	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
LILRB4	metacluster_113.3	MYBL1; MYBL1; MYBL2; MYBL2; OVOL1; OVOL2 (directAnnotation). MYB; MYBL1; MYBL1; MYBL1; MYBL1; MYBL2; OVOL1 (inferredBy_Orthology).
LILRB4	cisbp__M08198	ELF1 (directAnnotation).
LILRB4	c2h2_zfs__M0393	KLF9 (inferredBy_Orthology).
LILRB4	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
LILRB4	hocomoco__HSF1_HUMAN.H11MO.1.A	HSF1 (directAnnotation).
LILRB4	transfac_pro__M01239	RELA (directAnnotation).
LILRB4	tfdimers__MD00031	MYB; ZEB1 (directAnnotation).
LILRB4	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
LILRB4	transfac_pro__M04706	RELA (directAnnotation).
LILRB4	hocomoco__HSF1_MOUSE.H11MO.1.A	HSF1 (inferredBy_Orthology).
LILRB4	hdpi__NFATC3	NFATC3 (directAnnotation).
LILRB4	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
LILRB4	taipale_tf_pairs__GCM2_SOX15_ATRCGGGYNNNNNYWTTGTNN_CAP_repr	GCM2; SOX15 (directAnnotation).
LILRB4	metacluster_190.8	ILF2; NFAT5; NFAT5; NFAT5; NFAT5; NFATC1; NFATC2; NFATC3; NFATC4; NFATC4 (directAnnotation).
LILRB4	transfac_pro__M06807	SALL2 (inferredBy_Orthology).
LILRB4	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
LILRB4	metacluster_97.2	GTF3A (inferredBy_Orthology).
LILRB4	taipale_tf_pairs__POU2F1_ELK1_NCCGGATATGCAN_CAP_repr	ELK1; POU2F1 (directAnnotation).
LILRB4	transfac_pro__M06902	ZNF611 (directAnnotation).
LILRB4	metacluster_88.3	ZNF513 (directAnnotation).
LILRB4	tfdimers__MD00226	ETS2; MYB (directAnnotation).
LILRB4	transfac_pro__M06025	ZNF195 (directAnnotation).
LILRB4	metacluster_29.5	ZFP69 (directAnnotation).
LILRB4	metacluster_62.3	HSF5 (directAnnotation).
LILRB4	tfdimers__MD00335	FOXP3; NKX2-1 (directAnnotation).
LILRB4	transfac_pro__M05484	ZNF212 (directAnnotation).
LILRB4	taipale_tf_pairs__TEAD4_CLOCK_GGWATGNNNNNNCACGTGN_CAP_repr	CLOCK; TEAD4 (directAnnotation).
LILRB4	transfac_pro__M05698	ZNF141 (directAnnotation).
LILRB4	metacluster_147.2	TBR1; TBX1; TBX1; TBX10; TBX15; TBX15; TBX2; TBX20; TBX20; TBX20; TBX20; TBX20; TBX20; TBX20; TBX21; TBX22; TBX3 (directAnnotation). TBX20 (inferredBy_Orthology).
LILRB4	taipale_tf_pairs__POU5F1_WATGCGCATW_HT	POU5F1 (directAnnotation).
LILRB4	taipale_tf_pairs__TEAD4_TCF3_NCAGGTGNGWATGYN_CAP_repr	TCF3; TEAD4 (directAnnotation).
LILRB4	jaspar__MA1108.2	MXI1 (directAnnotation).
LILRB4	taipale_tf_pairs__TCF15_NACAYATGNN_HT	TCF15 (directAnnotation).
LILRB4	taipale_tf_pairs__TEAD4_CLOCK_NCACGTGNNNNNNCATWCC_CAP_repr	CLOCK; TEAD4 (directAnnotation).
LILRB4	metacluster_142.7	POU2F2; POU2F3; POU3F1; POU3F2; POU3F2; POU3F4; POU3F4; POU5F1 (directAnnotation).
LILRB4	metacluster_155.6	ZNF212; ZNF785; ZSCAN4 (directAnnotation).
LILRB4	hocomoco__PO5F1_HUMAN.H11MO.1.A	POU5F1 (directAnnotation).
LILRB4	dbtfbs__ZNF48_representative_N1	ZNF48 (directAnnotation).
LILRB4	flyfactorsurvey__Ets98B_SANGER_10_FBgn0005659	SPDEF (inferredBy_Orthology).
LILRB4	transfac_pro__M06830	ZNF528 (directAnnotation).
LILRB4	transfac_public__M00412	ZEB1 (directAnnotation).
LILRB4	transfac_pro__M04898	NANOG (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."