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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LHX8

Summary for LHX8

Gene information	Gene symbol	LHX8
	Ensembl ID	ENSG00000162624
	Entrez ID	431707
	Gene name	LIM homeobox 8
	Synonyms	Lhx7
	Gene type	protein_coding
	UniProtAcc	Q68G74

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Dataset with differentially expressed gene: LHX8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.687847	0.00e+00

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Expression of LHX8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LHX8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LHX8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LHX8	hsa-miR-30c-5p	99.2352	NM_001001933
LHX8	hsa-miR-30b-5p	99.2352	NM_001001933
LHX8	hsa-miR-30e-5p	99.2352	NM_001001933
LHX8	hsa-miR-30d-5p	99.2352	NM_001001933
LHX8	hsa-miR-30a-5p	99.2352	NM_001001933
LHX8	hsa-miR-3613-3p	99.0554	NM_001001933
LHX8	hsa-miR-513b-5p	97.9965	NM_001256114
LHX8	hsa-miR-520h	96.4125	NM_001001933
LHX8	hsa-miR-520g-3p	96.4125	NM_001001933
LHX8	hsa-miR-10522-5p	93.222	NM_001256114
LHX8	hsa-miR-382-5p	92.8818	NM_001256114
LHX8	hsa-miR-541-3p	92.8087	NM_001256114
LHX8	hsa-miR-654-5p	92.8087	NM_001256114
LHX8	hsa-miR-2052	92.3363	NM_001256114
LHX8	hsa-miR-7851-3p	90.9102	NM_001001933
LHX8	hsa-miR-1468-3p	90.6573	NM_001001933
LHX8	hsa-miR-603	90.5863	NM_001256114
LHX8	hsa-miR-3973	89.4976	NM_001256114
LHX8	hsa-miR-302e	89.0126	NM_001001933
LHX8	hsa-miR-520e-3p	89.0126	NM_001001933
LHX8	hsa-miR-520d-3p	88.5368	NM_001001933
LHX8	hsa-miR-302a-3p	88.5368	NM_001001933
LHX8	hsa-miR-520c-3p	88.5368	NM_001001933
LHX8	hsa-miR-520b-3p	88.5368	NM_001001933
LHX8	hsa-miR-372-3p	88.5368	NM_001001933
LHX8	hsa-miR-520a-3p	88.5368	NM_001001933
LHX8	hsa-miR-302b-3p	88.5368	NM_001001933
LHX8	hsa-miR-302d-3p	88.5368	NM_001001933
LHX8	hsa-miR-302c-3p	88.5368	NM_001001933
LHX8	hsa-miR-373-3p	88.5368	NM_001001933
LHX8	hsa-miR-507	87.4494	NM_001256114
LHX8	hsa-miR-513a-3p	86.612	NM_001256114
LHX8	hsa-miR-513c-3p	86.612	NM_001256114
LHX8	hsa-miR-4470	86.459	NM_001001933
LHX8	hsa-miR-3688-3p	86.3758	NM_001256114
LHX8	hsa-miR-410-3p	86.3478	NM_001256114
LHX8	hsa-miR-643	86.1442	NM_001001933
LHX8	hsa-miR-3646	85.6986	NM_001256114
LHX8	hsa-miR-27a-5p	85.6041	NM_001256114
LHX8	hsa-miR-7844-5p	85.3409	NM_001256114
LHX8	hsa-miR-600	85.2946	NM_001256114
LHX8	hsa-miR-3662	84.923	NM_001256114
LHX8	hsa-miR-552-3p	84.011	NM_001256114
LHX8	hsa-miR-557	82.6162	NM_001256114
LHX8	hsa-miR-3606-3p	82.4078	NM_001256114
LHX8	hsa-miR-4659b-3p	82.2971	NM_001256114
LHX8	hsa-miR-4659a-3p	82.2971	NM_001256114
LHX8	hsa-miR-1910-5p	82.2366	NM_001256114
LHX8	hsa-miR-3180-5p	81.3008	NM_001256114
LHX8	hsa-miR-525-5p	81.1082	NM_001001933

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Motifs and transcription factors (TFs) regulating LHX8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LHX8	metacluster_7.13	ZFX (directAnnotation).
LHX8	cisbp__M01863	ZNF711 (inferredBy_Orthology).
LHX8	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
LHX8	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
LHX8	transfac_pro__M05479	ZNF580 (directAnnotation).
LHX8	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LHX8	metacluster_182.10	ZFX (directAnnotation).
LHX8	hdpi__ETV4	ETV4 (directAnnotation).
LHX8	transfac_pro__M06071	ZNF814 (directAnnotation).
LHX8	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
LHX8	jaspar__MA0079.5	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."