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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LHX1

Summary for LHX1

Gene information	Gene symbol	LHX1
	Ensembl ID	ENSG00000274577
	Entrez ID	3975
	Gene name	LIM homeobox 1
	Synonyms	LIM-1\|LIM1
	Gene type	protein_coding
	UniProtAcc	P48742

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Dataset with differentially expressed gene: LHX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.76867	5.95e-03
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.907415	0.00e+00

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Expression of LHX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LHX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LHX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LHX1	hsa-miR-182-5p	97.4119	NM_005568
LHX1	hsa-miR-4482-3p	97.374	NM_005568
LHX1	hsa-miR-3927-3p	97.3685	NM_005568
LHX1	hsa-miR-6831-5p	96.7534	NM_005568
LHX1	hsa-miR-5011-5p	95.8618	NM_005568
LHX1	hsa-miR-4650-3p	94.1535	NM_005568
LHX1	hsa-miR-943	92.2141	NM_005568
LHX1	hsa-miR-1277-5p	91.6727	NM_005568
LHX1	hsa-miR-539-5p	91.1457	NM_005568
LHX1	hsa-miR-30e-5p	89.2609	NM_005568
LHX1	hsa-miR-30d-5p	89.2609	NM_005568
LHX1	hsa-miR-30a-5p	89.2609	NM_005568
LHX1	hsa-miR-340-5p	89.0178	NM_005568
LHX1	hsa-miR-4700-3p	86.9881	NM_005568
LHX1	hsa-miR-224-5p	86.7388	NM_005568
LHX1	hsa-miR-2113	86.4745	NM_005568
LHX1	hsa-miR-30b-5p	85.9833	NM_005568
LHX1	hsa-miR-30c-5p	85.9833	NM_005568
LHX1	hsa-miR-12133	85.2694	NM_005568
LHX1	hsa-miR-450b-5p	83.4354	NM_005568
LHX1	hsa-miR-96-5p	83.3176	NM_005568
LHX1	hsa-miR-3173-5p	83.1045	NM_005568
LHX1	hsa-miR-4433a-5p	82.5292	NM_005568
LHX1	hsa-miR-3143	82.4814	NM_005568
LHX1	hsa-miR-6818-5p	81.8389	NM_005568
LHX1	hsa-miR-6799-3p	81.5364	NM_005568
LHX1	hsa-miR-6867-5p	81.5213	NM_005568
LHX1	hsa-miR-646	81.3925	NM_005568
LHX1	hsa-miR-5009-5p	81.2965	NM_005568
LHX1	hsa-miR-1271-5p	81.1425	NM_005568
LHX1	hsa-miR-6750-3p	81.1076	NM_005568
LHX1	hsa-miR-12127	80.9123	NM_005568
LHX1	hsa-miR-1260b	80.8649	NM_005568
LHX1	hsa-miR-1260a	80.8649	NM_005568
LHX1	hsa-miR-1224-3p	80.4442	NM_005568
LHX1	hsa-miR-8058	80.2766	NM_005568

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Motifs and transcription factors (TFs) regulating LHX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LHX1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
LHX1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
LHX1	transfac_pro__M02281	SP1 (directAnnotation).
LHX1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
LHX1	transfac_pro__M03876	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."