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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LGR4

Summary for LGR4

Gene information	Gene symbol	LGR4
	Ensembl ID	ENSG00000205213
	Entrez ID	55366
	Gene name	leucine rich repeat containing G protein-coupled receptor 4
	Synonyms	GPR48
	Gene type	protein_coding
	UniProtAcc	Q9BXB1

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Dataset with differentially expressed gene: LGR4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.329353	1.63e-22

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Expression of LGR4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LGR4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LGR4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LGR4	hsa-miR-449a	98.1868	NM_018490
LGR4	hsa-miR-34a-5p	98.1868	NM_018490
LGR4	hsa-miR-34c-5p	97.5324	NM_018490
LGR4	hsa-miR-449b-5p	97.5324	NM_018490
LGR4	hsa-miR-374a-3p	95.4341	NM_018490
LGR4	hsa-miR-3646	94.6034	NM_018490
LGR4	hsa-miR-570-3p	92.1068	NM_018490
LGR4	hsa-miR-585-5p	90.5551	NM_018490
LGR4	hsa-miR-4266	89.9463	NM_018490
LGR4	hsa-let-7f-1-3p	89.1752	NM_018490
LGR4	hsa-let-7b-3p	89.1752	NM_018490
LGR4	hsa-miR-98-3p	89.1752	NM_018490
LGR4	hsa-let-7a-3p	89.1752	NM_018490
LGR4	hsa-miR-497-3p	89.0281	NM_018490
LGR4	hsa-miR-4324	88.2561	NM_018490
LGR4	hsa-miR-4760-5p	88.1366	NM_018490
LGR4	hsa-miR-4267	87.5924	NM_018490
LGR4	hsa-miR-451b	86.5849	NM_018490
LGR4	hsa-miR-664a-3p	86.387	NM_018490
LGR4	hsa-miR-361-5p	86.186	NM_018490
LGR4	hsa-miR-23a-3p	85.7446	NM_018490
LGR4	hsa-miR-23b-3p	85.7446	NM_018490
LGR4	hsa-miR-23c	85.7446	NM_018490
LGR4	hsa-miR-6508-5p	85.5407	NM_018490
LGR4	hsa-miR-3529-3p	85.1815	NM_018490
LGR4	hsa-miR-548av-3p	85.0869	NM_018490
LGR4	hsa-miR-8067	84.9488	NM_018490
LGR4	hsa-miR-8061	84.4558	NM_018490
LGR4	hsa-miR-3662	82.6652	NM_018490
LGR4	hsa-miR-328-3p	81.7592	NM_018490
LGR4	hsa-miR-141-3p	80.6397	NM_018490
LGR4	hsa-miR-200a-3p	80.6397	NM_018490
LGR4	hsa-miR-892c-5p	80.1364	NM_018490

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Motifs and transcription factors (TFs) regulating LGR4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LGR4	metacluster_135.11	NR2C2 (directAnnotation).
LGR4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LGR4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LGR4	metacluster_7.13	ZFX (directAnnotation).
LGR4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LGR4	cisbp__M00968	MTF2 (directAnnotation).
LGR4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LGR4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
LGR4	cisbp__M00341	PAX6 (directAnnotation).
LGR4	metacluster_198.3	ZFP64 (directAnnotation).
LGR4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
LGR4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
LGR4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
LGR4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
LGR4	cisbp__M00788	ZFY (inferredBy_Orthology).
LGR4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
LGR4	metacluster_175.1	ZNF283 (directAnnotation).
LGR4	hdpi__ZNF304	ZNF304 (directAnnotation).
LGR4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
LGR4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
LGR4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
LGR4	transfac_pro__M01199	TRIM28 (directAnnotation).
LGR4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
LGR4	metacluster_151.2	ZNF23 (directAnnotation).
LGR4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LGR4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
LGR4	transfac_pro__M03806	ZBTB7C (directAnnotation).
LGR4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."