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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LEPROTL1

Summary for LEPROTL1

Gene information	Gene symbol	LEPROTL1
	Ensembl ID	ENSG00000104660
	Entrez ID	23484
	Gene name	leptin receptor overlapping transcript like 1
	Synonyms	my047\|Vps55
	Gene type	protein_coding
	UniProtAcc	O95214

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Dataset with differentially expressed gene: LEPROTL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.252316	2.36e-35
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.305109	3.43e-18
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	-0.391048	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	-0.28873	1.40e-45
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.388024	1.59e-03
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.505622	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.302118	3.70e-28
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.257399	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	CD4+ T cells	-0.291733	3.00e-14
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.334801	1.11e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	0.284764	8.76e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.438139	9.87e-12
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.316369	8.57e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.525538	0.00e+00

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Expression of LEPROTL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LEPROTL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LEPROTL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LEPROTL1	hsa-miR-202-3p	98.036	NM_015344
LEPROTL1	hsa-miR-4803	96.3207	NM_015344
LEPROTL1	hsa-miR-500a-5p	94.5812	NM_015344
LEPROTL1	hsa-miR-5000-5p	93.9834	NM_015344
LEPROTL1	hsa-miR-152-3p	93.8509	NM_015344
LEPROTL1	hsa-miR-148a-3p	93.8509	NM_015344
LEPROTL1	hsa-miR-148b-3p	93.8509	NM_015344
LEPROTL1	hsa-miR-4291	93.7315	NM_015344
LEPROTL1	hsa-miR-590-3p	93.1955	NM_015344
LEPROTL1	hsa-miR-625-3p	91.4083	NM_015344
LEPROTL1	hsa-miR-7162-3p	90.651	NM_015344
LEPROTL1	hsa-miR-4500	89.8122	NM_015344
LEPROTL1	hsa-miR-373-5p	89.7165	NM_015344
LEPROTL1	hsa-miR-371b-5p	89.7165	NM_015344
LEPROTL1	hsa-miR-616-5p	89.7165	NM_015344
LEPROTL1	hsa-miR-4720-5p	87.9725	NM_015344
LEPROTL1	hsa-miR-4799-3p	87.9725	NM_015344
LEPROTL1	hsa-miR-5588-5p	87.9725	NM_015344
LEPROTL1	hsa-miR-548t-5p	87.9158	NM_015344
LEPROTL1	hsa-miR-548az-5p	87.9158	NM_015344
LEPROTL1	hsa-miR-450b-5p	87.8595	NM_001128208
LEPROTL1	hsa-miR-448	87.1182	NM_015344
LEPROTL1	hsa-miR-526b-5p	86.5377	NM_015344
LEPROTL1	hsa-let-7i-5p	86.1041	NM_015344
LEPROTL1	hsa-let-7f-5p	86.1041	NM_015344
LEPROTL1	hsa-let-7c-5p	86.1041	NM_015344
LEPROTL1	hsa-let-7b-5p	86.1041	NM_015344
LEPROTL1	hsa-let-7e-5p	86.1041	NM_015344
LEPROTL1	hsa-miR-98-5p	86.1041	NM_015344
LEPROTL1	hsa-let-7a-5p	86.1041	NM_015344
LEPROTL1	hsa-let-7g-5p	86.1041	NM_015344
LEPROTL1	hsa-miR-9983-3p	85.81	NM_015344
LEPROTL1	hsa-miR-3688-3p	84.829	NM_015344
LEPROTL1	hsa-miR-5580-3p	83.2108	NM_015344
LEPROTL1	hsa-miR-587	83.0265	NM_015344
LEPROTL1	hsa-miR-4458	82.7549	NM_015344
LEPROTL1	hsa-let-7d-5p	82.7549	NM_015344
LEPROTL1	hsa-miR-1247-3p	81.3183	NM_001128208
LEPROTL1	hsa-miR-380-3p	81.036	NM_015344
LEPROTL1	hsa-miR-129-5p	81.0232	NM_015344
LEPROTL1	hsa-miR-5692a	80.9585	NM_015344
LEPROTL1	hsa-miR-944	80.7157	NM_015344
LEPROTL1	hsa-miR-4257	80.6707	NM_015344
LEPROTL1	hsa-miR-548z	80.6672	NM_015344
LEPROTL1	hsa-miR-548h-3p	80.6672	NM_015344
LEPROTL1	hsa-miR-548d-3p	80.6672	NM_015344
LEPROTL1	hsa-miR-548ac	80.6672	NM_015344
LEPROTL1	hsa-miR-548bb-3p	80.6672	NM_015344
LEPROTL1	hsa-miR-3121-3p	80.5598	NM_015344
LEPROTL1	hsa-miR-3143	80.4836	NM_015344

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Motifs and transcription factors (TFs) regulating LEPROTL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LEPROTL1	transfac_pro__M02848	EGR1 (inferredBy_Orthology).
LEPROTL1	transfac_pro__M07475	TBX5 (inferredBy_Orthology).
LEPROTL1	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
LEPROTL1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LEPROTL1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
LEPROTL1	jaspar__MA1650.1	ZBTB14 (directAnnotation).
LEPROTL1	transfac_pro__M02090	E2F4 (directAnnotation).
LEPROTL1	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
LEPROTL1	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
LEPROTL1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
LEPROTL1	hdpi__HES5	HES5 (directAnnotation).
LEPROTL1	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
LEPROTL1	kznf__EGR2_Barrera2016.1_PBM	EGR2 (directAnnotation).
LEPROTL1	taipale_cyt_meth__GCM1_RTGCGGGTN_eDBD	GCM1 (directAnnotation).
LEPROTL1	metacluster_19.9	AHR; AHR; SREBF1; SREBF1; SREBF2; SREBF2 (directAnnotation). SREBF1 (inferredBy_Orthology).
LEPROTL1	metacluster_198.2	AHR; AHR; ARNT; BHLHE40; MAX; MYC; ZNF780A (directAnnotation). MTF1 (inferredBy_Orthology).
LEPROTL1	taipale_tf_pairs__GCM2_HES7_RTRNKGGTNNNGCACGYGNN_CAP_repr	GCM2; HES7 (directAnnotation).
LEPROTL1	hdpi__NRL	NRL (directAnnotation).
LEPROTL1	hdpi__OTUD4	OTUD4 (directAnnotation).
LEPROTL1	kznf__ZBTB26_Schmitges2016_ChIP-seq	ZBTB26 (directAnnotation).
LEPROTL1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
LEPROTL1	swissregulon__hs__EPAS1	EPAS1 (directAnnotation).
LEPROTL1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
LEPROTL1	transfac_pro__M02898	SMAD3 (directAnnotation).
LEPROTL1	transfac_public__M00373	PAX4 (directAnnotation).
LEPROTL1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
LEPROTL1	cisbp__M07938	E2F1 (directAnnotation).
LEPROTL1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
LEPROTL1	hocomoco__IRX2_HUMAN.H11MO.0.D	IRX2 (directAnnotation).
LEPROTL1	transfac_pro__M00322	MAX; MYC (directAnnotation).
LEPROTL1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
LEPROTL1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
LEPROTL1	tfdimers__MD00391	KLF4 (directAnnotation).
LEPROTL1	tfdimers__MD00557	MZF1 (directAnnotation).
LEPROTL1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
LEPROTL1	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
LEPROTL1	cisbp__M01864	EGR1 (inferredBy_Orthology).
LEPROTL1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
LEPROTL1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LEPROTL1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
LEPROTL1	metacluster_135.11	NR2C2 (directAnnotation).
LEPROTL1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LEPROTL1	tfdimers__MD00038	TFAP2C (directAnnotation).
LEPROTL1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LEPROTL1	metacluster_7.13	ZFX (directAnnotation).
LEPROTL1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LEPROTL1	cisbp__M00968	MTF2 (directAnnotation).
LEPROTL1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LEPROTL1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
LEPROTL1	cisbp__M00341	PAX6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."