DRMref Logo

Home

Download

Statistics

Landscape

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Datasets with differential expression of this gene

leaf

Expression of this gene in the resistant group across all datasets and cell types

leaf

Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

leaf

Known drug resistance mechanisms of this gene (This gene does not contain this module)

leaf

MicroRNAs (miRNAs) regulating this gene

leaf

Motifs and transcription factors (TFs) regulating this gene

leaf

Acts as a transcription factor (This gene does not contain this module)

leaf

Acts as a drug target< (This gene does not contain this module)

Gene: LARP4

Summary for LARP4

Gene informationGene symbol

LARP4

Ensembl ID

ENSG00000161813

Entrez ID

113251

Gene nameLa ribonucleoprotein 4
SynonymsPP13296
Gene typeprotein_coding
UniProtAcc

NA


Top

Dataset with differentially expressed gene: LARP4

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.294081.10e-06

Top

Expression of LARP4 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

Top

Significant ligand-receptor pairs related to LARP4

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating LARP4

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
LARP4hsa-miR-5011-5p99.9999NM_052879
LARP4hsa-miR-190a-3p99.9986NM_052879
LARP4hsa-miR-590-3p99.2687NM_052879
LARP4hsa-miR-576-5p99.1735NM_052879
LARP4hsa-miR-848598.6349NM_052879
LARP4hsa-miR-3121-3p98.0551NM_052879
LARP4hsa-miR-181b-5p97.969NM_052879
LARP4hsa-miR-181d-5p97.969NM_052879
LARP4hsa-miR-426297.969NM_052879
LARP4hsa-miR-181a-5p97.969NM_052879
LARP4hsa-miR-181c-5p97.969NM_052879
LARP4hsa-miR-548t-3p97.025NM_052879
LARP4hsa-miR-548aa97.025NM_052879
LARP4hsa-miR-548ap-3p97.025NM_052879
LARP4hsa-miR-656-3p96.687NM_052879
LARP4hsa-miR-6751-5p96.3077NM_052879
LARP4hsa-miR-889-3p96.1592NM_052879
LARP4hsa-miR-4735-5p95.7904NM_052879
LARP4hsa-miR-6803-5p95.7251NM_052879
LARP4hsa-miR-477594.9974NM_052879
LARP4hsa-miR-1277-5p94.9623NM_052879
LARP4hsa-miR-1212494.743NM_052879
LARP4hsa-miR-302c-5p94.6049NM_052879
LARP4hsa-miR-493-5p94.1915NM_052879
LARP4hsa-miR-548c-3p93.9984NM_052879
LARP4hsa-miR-125a-3p92.8931NM_052879
LARP4hsa-miR-94492.367NM_001170804
LARP4hsa-miR-364691.8693NM_052879
LARP4hsa-miR-1250-3p91.8104NM_052879
LARP4hsa-miR-432890.9943NM_052879
LARP4hsa-miR-126590.9837NM_052879
LARP4hsa-miR-426390.6985NM_052879
LARP4hsa-miR-568090.6829NM_052879
LARP4hsa-let-7a-2-3p90.3313NM_052879
LARP4hsa-let-7g-3p90.3313NM_052879
LARP4hsa-miR-506-5p90.2568NM_001170804
LARP4hsa-miR-548h-3p90.1422NM_052879
LARP4hsa-miR-548ac90.1422NM_052879
LARP4hsa-miR-548d-3p90.1422NM_052879
LARP4hsa-miR-548z90.1422NM_052879
LARP4hsa-miR-548bb-3p90.1422NM_052879
LARP4hsa-miR-4799-5p89.863NM_052879
LARP4hsa-miR-397489.0094NM_052879
LARP4hsa-miR-143-5p88.9485NM_052879
LARP4hsa-miR-4762-5p88.8936NM_052879
LARP4hsa-miR-330-3p88.8536NM_052879
LARP4hsa-miR-520d-5p88.8126NM_052879
LARP4hsa-miR-805988.798NM_052879
LARP4hsa-miR-570-3p88.6387NM_052879
LARP4hsa-miR-6809-3p88.2932NM_052879
Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating LARP4

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
LARP4metacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LARP4metacluster_144.3ZNF704; ZNF704 (directAnnotation).
LARP4metacluster_7.13ZFX (directAnnotation).
LARP4kznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
LARP4metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LARP4metacluster_160.20JUND; PRDM15 (directAnnotation).
LARP4metacluster_198.3ZFP64 (directAnnotation).
LARP4metacluster_141.5NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
LARP4metacluster_61.1DEAF1; DEAF1 (directAnnotation).
LARP4cisbp__M00788ZFY (inferredBy_Orthology).
LARP4metacluster_175.1ZNF283 (directAnnotation).
LARP4hdpi__ZNF304ZNF304 (directAnnotation).
LARP4metacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
LARP4kznf__ZNF682_Isakova2017_SMiLE-seqZNF682 (directAnnotation).
Page: 1

Top

Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."