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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: LAMTOR3

Summary for LAMTOR3

Gene informationGene symbol

LAMTOR3

Ensembl ID

ENSG00000109270

Entrez ID

8649

Gene namelate endosomal/lysosomal adaptor, MAPK and MTOR activator 3
SynonymsMAP2K1IP1|MAPBP|MAPKSP1|MP1|Ragulator3
Gene typeprotein_coding
UniProtAcc

Q9UHA4


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Dataset with differentially expressed gene: LAMTOR3

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.3465180.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.51260.00e+00

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Expression of LAMTOR3 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to LAMTOR3

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LAMTOR3

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
LAMTOR3hsa-miR-4795-3p99.7162NM_021970
LAMTOR3hsa-miR-64596.7919NM_021970
LAMTOR3hsa-miR-10523-5p91.9633NM_021970
LAMTOR3hsa-miR-1468-3p91.6715NM_021970
LAMTOR3hsa-miR-471891.0862NM_021970
LAMTOR3hsa-miR-548n90.4588NM_021970
LAMTOR3hsa-miR-5591-5p89.3953NM_001243736
LAMTOR3hsa-miR-430089.3953NM_001243736
LAMTOR3hsa-miR-653-5p89.1931NM_021970
LAMTOR3hsa-miR-1287-5p88.7203NM_001243736
LAMTOR3hsa-miR-508-3p88.2731NM_001243736
LAMTOR3hsa-miR-329-3p88.1949NM_021970
LAMTOR3hsa-miR-362-3p88.1949NM_021970
LAMTOR3hsa-miR-4764-3p88.1696NM_001243736
LAMTOR3hsa-miR-52788.0347NM_021970
LAMTOR3hsa-miR-518a-5p88.0347NM_021970
LAMTOR3hsa-miR-1250-3p87.9743NM_021970
LAMTOR3hsa-miR-848587.297NM_021970
LAMTOR3hsa-miR-181a-2-3p86.7049NM_021970
LAMTOR3hsa-miR-92086.4995NM_001243736
LAMTOR3hsa-miR-6726-5p86.4995NM_001243736
LAMTOR3hsa-miR-490-5p85.8297NM_021970
LAMTOR3hsa-miR-6836-5p84.6284NM_021970
LAMTOR3hsa-miR-613284.6284NM_021970
LAMTOR3hsa-miR-3151-3p84.1217NM_021970
LAMTOR3hsa-miR-806283.6877NM_001243736
LAMTOR3hsa-miR-4690-5p83.2213NM_021970
LAMTOR3hsa-miR-24-1-5p82.6945NM_021970
LAMTOR3hsa-miR-24-2-5p82.6945NM_021970
LAMTOR3hsa-miR-513c-3p82.6547NM_021970
LAMTOR3hsa-miR-513a-3p82.6547NM_021970
LAMTOR3hsa-miR-5579-5p82.2505NM_021970
LAMTOR3hsa-miR-1228-3p81.6785NM_021970
LAMTOR3hsa-miR-425581.4109NM_021970
LAMTOR3hsa-miR-576-5p81.36NM_021970
LAMTOR3hsa-miR-316781.0799NM_021970
LAMTOR3hsa-miR-126180.3816NM_021970
LAMTOR3hsa-miR-453380.2519NM_021970
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Motifs and transcription factors (TFs) regulating LAMTOR3

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
LAMTOR3metacluster_191.2ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
LAMTOR3taipale_tf_pairs__ETS2_RCCGGAAGTG_HTETS2 (directAnnotation).
LAMTOR3metacluster_191.3EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
LAMTOR3hdpi__ETV4ETV4 (directAnnotation).
LAMTOR3metacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."