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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LAMP3

Summary for LAMP3

Gene information	Gene symbol	LAMP3
	Ensembl ID	ENSG00000078081
	Entrez ID	27074
	Gene name	lysosomal associated membrane protein 3
	Synonyms	CD208\|DC-LAMP\|DCLAMP\|LAMP\|TSC403
	Gene type	protein_coding
	UniProtAcc	Q9UQV4

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Dataset with differentially expressed gene: LAMP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.99902	3.68e-30
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.439232	0.00e+00

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Expression of LAMP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LAMP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
LAMP3	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating LAMP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LAMP3	hsa-miR-4677-5p	97.8605	NM_014398
LAMP3	hsa-miR-299-5p	96.011	NM_014398
LAMP3	hsa-miR-3613-3p	95.7026	NM_014398
LAMP3	hsa-miR-4796-3p	94.1585	NM_014398
LAMP3	hsa-miR-579-3p	92.4401	NM_014398
LAMP3	hsa-miR-664b-3p	92.4401	NM_014398
LAMP3	hsa-miR-15b-5p	91.7205	NM_014398
LAMP3	hsa-miR-15a-5p	91.7205	NM_014398
LAMP3	hsa-miR-16-5p	91.7205	NM_014398
LAMP3	hsa-miR-195-5p	91.7205	NM_014398
LAMP3	hsa-miR-3202	91.214	NM_014398
LAMP3	hsa-miR-424-5p	91.185	NM_014398
LAMP3	hsa-miR-6838-5p	91.185	NM_014398
LAMP3	hsa-miR-497-5p	91.185	NM_014398
LAMP3	hsa-miR-499a-5p	90.9336	NM_014398
LAMP3	hsa-miR-4496	88.6483	NM_014398
LAMP3	hsa-miR-12124	87.8144	NM_014398
LAMP3	hsa-miR-199b-3p	86.429	NM_014398
LAMP3	hsa-miR-3129-5p	86.429	NM_014398
LAMP3	hsa-miR-199a-3p	86.429	NM_014398
LAMP3	hsa-miR-372-5p	86.045	NM_014398
LAMP3	hsa-miR-4524a-5p	85.2014	NM_014398
LAMP3	hsa-miR-4524b-5p	85.2014	NM_014398
LAMP3	hsa-miR-4478	84.5335	NM_014398
LAMP3	hsa-miR-651-3p	83.2549	NM_014398
LAMP3	hsa-miR-548ah-5p	81.6063	NM_014398
LAMP3	hsa-miR-3609	81.6063	NM_014398
LAMP3	hsa-miR-10397-5p	80.3887	NM_014398

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Motifs and transcription factors (TFs) regulating LAMP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LAMP3	metacluster_52.11	ZNF184 (directAnnotation).
LAMP3	cisbp__M00341	PAX6 (directAnnotation).
LAMP3	jaspar__MA1650.1	ZBTB14 (directAnnotation).
LAMP3	tfdimers__MD00364	WT1 (directAnnotation).
LAMP3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LAMP3	transfac_pro__M06609	ZKSCAN4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."