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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LAMP2

Summary for LAMP2

Gene information	Gene symbol	LAMP2
	Ensembl ID	ENSG00000005893
	Entrez ID	3920
	Gene name	lysosomal associated membrane protein 2
	Synonyms	CD107b
	Gene type	protein_coding
	UniProtAcc	P13473

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Dataset with differentially expressed gene: LAMP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.311264	2.22e-07
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.274637	4.36e-06
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.285223	1.02e-11
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.342429	2.52e-44
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.384871	1.75e-14
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.320566	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.73348	0.00e+00

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Expression of LAMP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LAMP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
LAMP2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating LAMP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LAMP2	hsa-miR-5011-5p	99.7671	NM_002294
LAMP2	hsa-miR-8485	99.6074	NM_013995
LAMP2	hsa-miR-190a-3p	99.5337	NM_002294
LAMP2	hsa-miR-6867-5p	97.6235	NM_002294
LAMP2	hsa-miR-8068	97.1719	NM_013995
LAMP2	hsa-miR-302b-5p	96.0269	NM_001122606
LAMP2	hsa-miR-616-5p	95.8357	NM_002294
LAMP2	hsa-miR-373-5p	95.8357	NM_002294
LAMP2	hsa-miR-371b-5p	95.8357	NM_002294
LAMP2	hsa-miR-302d-5p	95.0422	NM_001122606
LAMP2	hsa-miR-4698	94.7867	NM_002294
LAMP2	hsa-miR-4500	94.2408	NM_002294
LAMP2	hsa-miR-5195-3p	92.9785	NM_002294
LAMP2	hsa-miR-145-5p	92.9785	NM_002294
LAMP2	hsa-miR-4802-3p	92.8083	NM_013995
LAMP2	hsa-let-7c-5p	92.1596	NM_002294
LAMP2	hsa-let-7i-5p	92.1596	NM_002294
LAMP2	hsa-let-7a-5p	92.1596	NM_002294
LAMP2	hsa-let-7f-5p	92.1596	NM_002294
LAMP2	hsa-let-7e-5p	92.1596	NM_002294
LAMP2	hsa-let-7g-5p	92.1596	NM_002294
LAMP2	hsa-let-7b-5p	92.1596	NM_002294
LAMP2	hsa-miR-98-5p	92.1596	NM_002294
LAMP2	hsa-miR-4282	91.176	NM_002294
LAMP2	hsa-miR-506-3p	90.9241	NM_002294
LAMP2	hsa-miR-194-5p	90.8692	NM_013995
LAMP2	hsa-miR-4666b	90.5869	NM_002294
LAMP2	hsa-miR-4703-3p	90.4307	NM_013995
LAMP2	hsa-miR-4458	89.6068	NM_002294
LAMP2	hsa-let-7d-5p	89.6068	NM_002294
LAMP2	hsa-miR-4273	89.5163	NM_001122606
LAMP2	hsa-miR-3925-5p	89.4912	NM_002294
LAMP2	hsa-miR-124-3p	89.4479	NM_002294
LAMP2	hsa-miR-7156-5p	89.1438	NM_001122606
LAMP2	hsa-let-7b-3p	88.9424	NM_013995
LAMP2	hsa-miR-98-3p	88.9424	NM_013995
LAMP2	hsa-let-7f-1-3p	88.9424	NM_013995
LAMP2	hsa-let-7a-3p	88.9424	NM_013995
LAMP2	hsa-miR-5688	88.93	NM_001122606
LAMP2	hsa-miR-12124	88.3617	NM_013995
LAMP2	hsa-miR-6815-3p	88.1897	NM_002294
LAMP2	hsa-miR-3529-3p	87.7405	NM_001122606
LAMP2	hsa-miR-4672	87.5549	NM_002294
LAMP2	hsa-miR-495-3p	87.117	NM_001122606
LAMP2	hsa-miR-450b-5p	87.0195	NM_001122606
LAMP2	hsa-miR-3976	86.8445	NM_002294
LAMP2	hsa-miR-548t-3p	86.1758	NM_002294
LAMP2	hsa-miR-548aa	86.1758	NM_002294
LAMP2	hsa-miR-548ap-3p	86.1758	NM_002294
LAMP2	hsa-miR-3915	85.9502	NM_001122606

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Motifs and transcription factors (TFs) regulating LAMP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LAMP2	metacluster_7.13	ZFX (directAnnotation).
LAMP2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
LAMP2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LAMP2	transfac_pro__M06071	ZNF814 (directAnnotation).
LAMP2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
LAMP2	jaspar__MA0079.5	SP1 (directAnnotation).
LAMP2	cisbp__M00341	PAX6 (directAnnotation).
LAMP2	metacluster_198.3	ZFP64 (directAnnotation).
LAMP2	cisbp__M00788	ZFY (inferredBy_Orthology).
LAMP2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
LAMP2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
LAMP2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
LAMP2	transfac_pro__M04826	EP300 (directAnnotation).
LAMP2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
LAMP2	transfac_pro__M04862	NRF1 (directAnnotation).
LAMP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LAMP2	jaspar__MA0748.2	YY2 (directAnnotation).
LAMP2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
LAMP2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
LAMP2	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
LAMP2	jaspar__MA0502.2	NFYB (directAnnotation).
LAMP2	transfac_pro__M06601	ZNF501 (directAnnotation).
LAMP2	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
LAMP2	taipale_tf_pairs__HOXB2_PAX1_NNMATTAGTCACGCWTSRNTG_CAP_repr	HOXB2; PAX1 (directAnnotation).
LAMP2	transfac_pro__M06135	ZNF28 (directAnnotation).
LAMP2	transfac_pro__M04913	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."