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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: LAMC1

Summary for LAMC1

Gene information	Gene symbol	LAMC1
	Ensembl ID	ENSG00000135862
	Entrez ID	3915
	Gene name	laminin subunit gamma 1
	Synonyms	LAMB2
	Gene type	protein_coding
	UniProtAcc	P11047

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Dataset with differentially expressed gene: LAMC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.268703	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.369077	4.21e-06
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.514592	0.00e+00

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Expression of LAMC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LAMC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LAMC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LAMC1	hsa-miR-124-3p	99.8861	NM_002293
LAMC1	hsa-miR-506-3p	99.8861	NM_002293
LAMC1	hsa-miR-892c-5p	97.5132	NM_002293
LAMC1	hsa-miR-22-3p	97.4788	NM_002293
LAMC1	hsa-miR-3163	96.7812	NM_002293
LAMC1	hsa-miR-506-5p	95.8883	NM_002293
LAMC1	hsa-miR-3148	95.3478	NM_002293
LAMC1	hsa-miR-6885-3p	95.2366	NM_002293
LAMC1	hsa-miR-4470	94.6519	NM_002293
LAMC1	hsa-miR-765	94.0182	NM_002293
LAMC1	hsa-miR-323a-3p	93.8015	NM_002293
LAMC1	hsa-miR-11181-3p	93.744	NM_002293
LAMC1	hsa-miR-4659a-3p	93.7246	NM_002293
LAMC1	hsa-miR-4659b-3p	93.7246	NM_002293
LAMC1	hsa-miR-5582-5p	93.5394	NM_002293
LAMC1	hsa-miR-3182	93.3596	NM_002293
LAMC1	hsa-miR-4803	92.9018	NM_002293
LAMC1	hsa-miR-4261	91.7857	NM_002293
LAMC1	hsa-miR-8067	91.78	NM_002293
LAMC1	hsa-miR-6508-5p	91.6559	NM_002293
LAMC1	hsa-miR-96-5p	91.4417	NM_002293
LAMC1	hsa-miR-377-3p	91.3618	NM_002293
LAMC1	hsa-miR-205-5p	91.1867	NM_002293
LAMC1	hsa-miR-7847-3p	91.1037	NM_002293
LAMC1	hsa-miR-4275	89.5745	NM_002293
LAMC1	hsa-miR-4676-3p	88.5139	NM_002293
LAMC1	hsa-miR-892c-3p	88.5139	NM_002293
LAMC1	hsa-miR-452-5p	88.5139	NM_002293
LAMC1	hsa-miR-605-3p	88.4656	NM_002293
LAMC1	hsa-miR-1271-5p	87.9118	NM_002293
LAMC1	hsa-miR-12133	87.9118	NM_002293
LAMC1	hsa-miR-7974	87.8641	NM_002293
LAMC1	hsa-miR-4529-5p	87.8319	NM_002293
LAMC1	hsa-miR-3942-3p	87.6499	NM_002293
LAMC1	hsa-miR-6832-5p	87.5899	NM_002293
LAMC1	hsa-miR-29a-3p	87.1651	NM_002293
LAMC1	hsa-miR-29b-3p	87.1651	NM_002293
LAMC1	hsa-miR-29c-3p	87.1651	NM_002293
LAMC1	hsa-miR-7975	87.058	NM_002293
LAMC1	hsa-miR-153-3p	86.8157	NM_002293
LAMC1	hsa-miR-548as-3p	86.4989	NM_002293
LAMC1	hsa-miR-340-5p	85.8608	NM_002293
LAMC1	hsa-miR-147b-5p	85.8046	NM_002293
LAMC1	hsa-miR-5196-5p	85.7056	NM_002293
LAMC1	hsa-miR-4747-5p	85.7056	NM_002293
LAMC1	hsa-miR-193b-3p	85.0183	NM_002293
LAMC1	hsa-miR-193a-3p	85.0183	NM_002293
LAMC1	hsa-miR-376b-3p	84.798	NM_002293
LAMC1	hsa-miR-376a-3p	84.798	NM_002293
LAMC1	hsa-miR-6873-5p	84.3357	NM_002293

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Motifs and transcription factors (TFs) regulating LAMC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LAMC1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
LAMC1	transfac_pro__M00652	NRF1 (directAnnotation).
LAMC1	transfac_pro__M04918	EGR1 (directAnnotation).
LAMC1	hdpi__TP73	TP73 (directAnnotation).
LAMC1	transfac_pro__M06135	ZNF28 (directAnnotation).
LAMC1	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
LAMC1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
LAMC1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
LAMC1	transfac_pro__M02089	E2F3 (directAnnotation).
LAMC1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
LAMC1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
LAMC1	transfac_pro__M04817	ZBTB33 (directAnnotation).
LAMC1	metacluster_143.13	ZBTB7A (directAnnotation).
LAMC1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
LAMC1	tfdimers__MD00483	ZBTB14 (directAnnotation).
LAMC1	cisbp__M07938	E2F1 (directAnnotation).
LAMC1	cisbp__M00968	MTF2 (directAnnotation).
LAMC1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
LAMC1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
LAMC1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
LAMC1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
LAMC1	jaspar__MA1122.1	TFDP1 (directAnnotation).
LAMC1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
LAMC1	"Lanoteplase"	DB06245	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."