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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: LAMA3

Summary for LAMA3

Gene information	Gene symbol	LAMA3
	Ensembl ID	ENSG00000053747
	Entrez ID	3909
	Gene name	laminin subunit alpha 3
	Synonyms	BM600-150kDa\|epiligrin\|kalinin-165kDa\|LAMNA\|nicein-150kDa
	Gene type	protein_coding
	UniProtAcc	Q16787

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Dataset with differentially expressed gene: LAMA3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.35099	2.53e-03
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.431251	0.00e+00

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Expression of LAMA3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LAMA3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LAMA3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LAMA3	hsa-miR-302c-5p	99.2083	NM_001127718
LAMA3	hsa-miR-4775	98.7166	NM_001127718
LAMA3	hsa-miR-520f-3p	96.9156	NM_000227
LAMA3	hsa-miR-520b-3p	96.7894	NM_000227
LAMA3	hsa-miR-520d-3p	96.7894	NM_000227
LAMA3	hsa-miR-520c-3p	96.7894	NM_000227
LAMA3	hsa-miR-372-3p	96.7894	NM_000227
LAMA3	hsa-miR-373-3p	96.7894	NM_000227
LAMA3	hsa-miR-520e-3p	96.7894	NM_000227
LAMA3	hsa-miR-302b-3p	96.7894	NM_000227
LAMA3	hsa-miR-302c-3p	96.7894	NM_000227
LAMA3	hsa-miR-302a-3p	96.7894	NM_000227
LAMA3	hsa-miR-302d-3p	96.7894	NM_000227
LAMA3	hsa-miR-520a-3p	96.7894	NM_000227
LAMA3	hsa-miR-302e	96.4999	NM_000227
LAMA3	hsa-miR-106b-5p	95.3932	NM_000227
LAMA3	hsa-miR-20a-5p	95.3932	NM_000227
LAMA3	hsa-miR-526b-3p	95.1033	NM_000227
LAMA3	hsa-miR-20b-5p	95.1033	NM_000227
LAMA3	hsa-miR-106a-5p	95.1033	NM_000227
LAMA3	hsa-miR-93-5p	95.1033	NM_000227
LAMA3	hsa-miR-519d-3p	95.1033	NM_000227
LAMA3	hsa-miR-17-5p	95.1033	NM_000227
LAMA3	hsa-miR-6801-5p	93.0698	NM_001127718
LAMA3	hsa-miR-10393-3p	93.0698	NM_001127718
LAMA3	hsa-miR-548ah-5p	91.8001	NM_000227
LAMA3	hsa-miR-3140-3p	91.7482	NM_001127718
LAMA3	hsa-miR-3609	91.4666	NM_000227
LAMA3	hsa-miR-4796-3p	90.9831	NM_000227
LAMA3	hsa-miR-12115	88.0255	NM_001127718
LAMA3	hsa-miR-3681-5p	88.0255	NM_001127718
LAMA3	hsa-miR-587	87.1812	NM_001127718
LAMA3	hsa-miR-3163	86.9154	NM_001127718
LAMA3	hsa-miR-556-3p	86.4495	NM_000227
LAMA3	hsa-miR-6849-5p	85.2676	NM_001127718
LAMA3	hsa-miR-6124	82.3536	NM_001127718
LAMA3	hsa-miR-500a-5p	81.0427	NM_001127718

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Motifs and transcription factors (TFs) regulating LAMA3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LAMA3	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
LAMA3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
LAMA3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
LAMA3	transfac_pro__M00716	ZBTB14 (directAnnotation).
LAMA3	hdpi__HIP2	UBE2K (directAnnotation).
LAMA3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
LAMA3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
LAMA3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
LAMA3	transfac_pro__M05981	ZNF233 (directAnnotation).
LAMA3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LAMA3	transfac_pro__M04950	EGR1 (directAnnotation).
LAMA3	transfac_pro__M06109	ZNF254 (directAnnotation).
LAMA3	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
LAMA3	transfac_pro__M06135	ZNF28 (directAnnotation).
LAMA3	metacluster_172.6	CHD2; E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
LAMA3	"Lanoteplase"	DB06245	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."