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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KPNA6

Summary for KPNA6

Gene information	Gene symbol	KPNA6
	Ensembl ID	ENSG00000025800
	Entrez ID	23633
	Gene name	karyopherin subunit alpha 6
	Synonyms	FLJ11249\|IPOA7\|KPNA7\|MGC17918
	Gene type	protein_coding
	UniProtAcc	O60684

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Dataset with differentially expressed gene: KPNA6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.543642	0.00e+00

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Expression of KPNA6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KPNA6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KPNA6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KPNA6	hsa-miR-19a-3p	97.2206	NM_012316
KPNA6	hsa-miR-19b-3p	97.2206	NM_012316
KPNA6	hsa-miR-6885-3p	96.5883	NM_012316
KPNA6	hsa-miR-6887-3p	96.1553	NM_012316
KPNA6	hsa-miR-1297	95.9216	NM_012316
KPNA6	hsa-miR-6823-3p	95.2228	NM_012316
KPNA6	hsa-miR-18a-5p	95.2041	NM_012316
KPNA6	hsa-miR-18b-5p	95.2041	NM_012316
KPNA6	hsa-miR-4735-3p	95.2041	NM_012316
KPNA6	hsa-miR-7156-3p	94.575	NM_012316
KPNA6	hsa-miR-2114-3p	94.5182	NM_012316
KPNA6	hsa-miR-4768-3p	94.4333	NM_012316
KPNA6	hsa-miR-6742-3p	94.2536	NM_012316
KPNA6	hsa-miR-3185	92.9826	NM_012316
KPNA6	hsa-miR-26b-5p	92.3298	NM_012316
KPNA6	hsa-miR-26a-5p	92.3298	NM_012316
KPNA6	hsa-miR-6077	92.0093	NM_012316
KPNA6	hsa-miR-7106-3p	91.9346	NM_012316
KPNA6	hsa-miR-4764-5p	91.4226	NM_012316
KPNA6	hsa-miR-548g-5p	91.2445	NM_012316
KPNA6	hsa-miR-548f-5p	91.2445	NM_012316
KPNA6	hsa-miR-548aj-5p	91.2445	NM_012316
KPNA6	hsa-miR-548x-5p	91.2445	NM_012316
KPNA6	hsa-miR-6809-3p	91.0381	NM_012316
KPNA6	hsa-miR-6868-3p	90.7295	NM_012316
KPNA6	hsa-miR-4465	90.604	NM_012316
KPNA6	hsa-miR-181a-2-3p	90.1133	NM_012316
KPNA6	hsa-miR-939-3p	89.7033	NM_012316
KPNA6	hsa-miR-6515-3p	88.6369	NM_012316
KPNA6	hsa-miR-767-3p	88.2777	NM_012316
KPNA6	hsa-miR-450b-5p	88.2375	NM_012316
KPNA6	hsa-miR-1224-3p	88.1709	NM_012316
KPNA6	hsa-miR-548e-5p	88.0838	NM_012316
KPNA6	hsa-miR-5580-5p	87.1103	NM_012316
KPNA6	hsa-miR-3926	87.0069	NM_012316
KPNA6	hsa-miR-6845-3p	86.6345	NM_012316
KPNA6	hsa-miR-152-5p	86.4969	NM_012316
KPNA6	hsa-miR-6756-3p	86.4183	NM_012316
KPNA6	hsa-miR-3127-3p	86.4183	NM_012316
KPNA6	hsa-miR-1277-5p	86.3779	NM_012316
KPNA6	hsa-miR-30b-5p	86.377	NM_012316
KPNA6	hsa-miR-30c-5p	86.377	NM_012316
KPNA6	hsa-miR-30d-5p	86.377	NM_012316
KPNA6	hsa-miR-30a-5p	86.377	NM_012316
KPNA6	hsa-miR-30e-5p	86.377	NM_012316
KPNA6	hsa-miR-378g	85.7301	NM_012316
KPNA6	hsa-miR-6828-3p	85.4357	NM_012316
KPNA6	hsa-miR-532-3p	85.1345	NM_012316
KPNA6	hsa-miR-1248	84.5377	NM_012316
KPNA6	hsa-miR-3944-5p	84.0598	NM_012316

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Motifs and transcription factors (TFs) regulating KPNA6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KPNA6	metacluster_7.13	ZFX (directAnnotation).
KPNA6	cisbp__M01863	ZNF711 (inferredBy_Orthology).
KPNA6	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KPNA6	metacluster_182.10	ZFX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."