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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KPNA1

Summary for KPNA1

Gene information	Gene symbol	KPNA1
	Ensembl ID	ENSG00000114030
	Entrez ID	3836
	Gene name	karyopherin subunit alpha 1
	Synonyms	IPOA5\|NPI-1\|RCH2\|SRP1
	Gene type	protein_coding
	UniProtAcc	P52294

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Dataset with differentially expressed gene: KPNA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.263458	4.08e-28

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Expression of KPNA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KPNA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KPNA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KPNA1	hsa-miR-3679-3p	99.6302	NM_002264
KPNA1	hsa-miR-6124	98.8576	NM_002264
KPNA1	hsa-miR-524-5p	97.8492	NM_002264
KPNA1	hsa-miR-520d-5p	97.8492	NM_002264
KPNA1	hsa-miR-449b-3p	96.599	NM_002264
KPNA1	hsa-miR-3613-3p	96.2952	NM_002264
KPNA1	hsa-miR-3125	95.6661	NM_002264
KPNA1	hsa-miR-181b-3p	95.6205	NM_002264
KPNA1	hsa-miR-181b-2-3p	95.6205	NM_002264
KPNA1	hsa-miR-4420	95.5741	NM_002264
KPNA1	hsa-miR-4293	95.4473	NM_002264
KPNA1	hsa-miR-3163	94.7394	NM_002264
KPNA1	hsa-miR-4691-3p	94.3958	NM_002264
KPNA1	hsa-miR-6859-5p	94.3365	NM_002264
KPNA1	hsa-miR-3916	94.3365	NM_002264
KPNA1	hsa-miR-520e-5p	94.3013	NM_002264
KPNA1	hsa-miR-3688-3p	93.7844	NM_002264
KPNA1	hsa-miR-570-3p	93.132	NM_002264
KPNA1	hsa-miR-6762-3p	92.1451	NM_002264
KPNA1	hsa-miR-3148	91.5068	NM_002264
KPNA1	hsa-miR-4262	91.0799	NM_002264
KPNA1	hsa-miR-6868-3p	91.0698	NM_002264
KPNA1	hsa-miR-873-5p	90.837	NM_002264
KPNA1	hsa-miR-205-5p	90.6483	NM_002264
KPNA1	hsa-miR-3180-5p	90.2623	NM_002264
KPNA1	hsa-miR-6827-5p	89.9545	NM_002264
KPNA1	hsa-miR-361-3p	89.8706	NM_002264
KPNA1	hsa-miR-541-5p	89.773	NM_002264
KPNA1	hsa-miR-7152-5p	89.5455	NM_002264
KPNA1	hsa-miR-6832-3p	89.4136	NM_002264
KPNA1	hsa-miR-548an	88.9282	NM_002264
KPNA1	hsa-miR-4797-3p	88.2073	NM_002264
KPNA1	hsa-miR-889-3p	88.1494	NM_002264
KPNA1	hsa-miR-3662	88.075	NM_002264
KPNA1	hsa-miR-146a-3p	88.02	NM_002264
KPNA1	hsa-miR-3170	87.9798	NM_002264
KPNA1	hsa-miR-498-3p	87.9293	NM_002264
KPNA1	hsa-miR-16-1-3p	87.9017	NM_002264
KPNA1	hsa-miR-6835-3p	87.791	NM_002264
KPNA1	hsa-miR-647	87.7815	NM_002264
KPNA1	hsa-miR-507	87.5939	NM_002264
KPNA1	hsa-miR-6855-5p	87.3145	NM_002264
KPNA1	hsa-miR-6768-5p	87.2716	NM_002264
KPNA1	hsa-miR-557	87.1917	NM_002264
KPNA1	hsa-miR-196a-3p	86.8439	NM_002264
KPNA1	hsa-miR-202-3p	86.8042	NM_002264
KPNA1	hsa-miR-5004-5p	86.7618	NM_002264
KPNA1	hsa-miR-5682	86.5925	NM_002264
KPNA1	hsa-miR-4714-5p	86.4959	NM_002264
KPNA1	hsa-miR-223-3p	86.477	NM_002264

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Motifs and transcription factors (TFs) regulating KPNA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KPNA1	metacluster_7.13	ZFX (directAnnotation).
KPNA1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
KPNA1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
KPNA1	metacluster_151.2	ZNF23 (directAnnotation).
KPNA1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
KPNA1	transfac_pro__M05479	ZNF580 (directAnnotation).
KPNA1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KPNA1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
KPNA1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KPNA1	metacluster_182.10	ZFX (directAnnotation).
KPNA1	hdpi__ETV4	ETV4 (directAnnotation).
KPNA1	jaspar__MA0748.2	YY2 (directAnnotation).
KPNA1	transfac_pro__M05628	ZNF735 (directAnnotation).
KPNA1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
KPNA1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KPNA1	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
KPNA1	jaspar__MA0079.5	SP1 (directAnnotation).
KPNA1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."