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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KLRG1

Summary for KLRG1

Gene information	Gene symbol	KLRG1
	Ensembl ID	ENSG00000139187
	Entrez ID	10219
	Gene name	killer cell lectin like receptor G1
	Synonyms	2F1\|CLEC15A\|MAFA\|MAFA-L
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KLRG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.320244	4.67e-19
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.339615	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.301365	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.285154	1.29e-29
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.289118	1.70e-05
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.643658	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.290211	6.56e-16
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.556946	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.532718	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	1.04741	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.757446	2.16e-19
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.357538	3.01e-10
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.359513	4.30e-06

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Expression of KLRG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLRG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KLRG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLRG1	hsa-miR-4251	94.9001	NM_005810
KLRG1	hsa-miR-6513-5p	91.314	NM_005810
KLRG1	hsa-miR-3200-5p	90.0106	NM_005810
KLRG1	hsa-miR-6854-5p	89.6289	NM_005810
KLRG1	hsa-miR-539-5p	89.5304	NM_005810
KLRG1	hsa-miR-4311	89.5282	NM_005810
KLRG1	hsa-miR-1178-3p	89.2302	NM_005810
KLRG1	hsa-miR-431-5p	86.509	NM_005810
KLRG1	hsa-miR-4784	86.005	NM_005810
KLRG1	hsa-miR-3150b-3p	86.005	NM_005810
KLRG1	hsa-miR-188-3p	85.9595	NM_005810
KLRG1	hsa-miR-889-3p	85.7107	NM_005810
KLRG1	hsa-miR-331-5p	85.2758	NM_005810
KLRG1	hsa-miR-4536-5p	84.6108	NM_005810
KLRG1	hsa-miR-4474-5p	83.5989	NM_005810

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Motifs and transcription factors (TFs) regulating KLRG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KLRG1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
KLRG1	transfac_pro__M04856	BATF (directAnnotation).
KLRG1	transfac_pro__M07285	ELF3 (directAnnotation).
KLRG1	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
KLRG1	metacluster_9.47	PAX7 (inferredBy_Orthology).
KLRG1	transfac_pro__M05927	ZNF408 (directAnnotation).
KLRG1	transfac_pro__M05542	SNAPC4 (directAnnotation).
KLRG1	taipale_tf_pairs__ETV2_PITX1_RSCGGAANNNNNGGMTTAN_CAP	ETV2; PITX1 (directAnnotation).
KLRG1	transfac_pro__M06249	ZNF616 (directAnnotation).
KLRG1	transfac_pro__M05380	NR2E1 (inferredBy_Orthology).
KLRG1	kznf__ZNF675_Najafabadi2015_ChIP-seq	ZNF675 (directAnnotation).
KLRG1	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).
KLRG1	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
KLRG1	tfdimers__MD00438	E2F1; NKX3-2 (directAnnotation).
KLRG1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
KLRG1	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRWMAACAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
KLRG1	transfac_pro__M06217	ZNF169 (directAnnotation).
KLRG1	taipale_tf_pairs__HOXD12_ETV4_RSCGGAAGTAATAAAN_CAP	ETV4; HOXD12 (directAnnotation).
KLRG1	transfac_pro__M06246	ZNF177 (directAnnotation).
KLRG1	metacluster_147.3	MGA; MGA; TBX1; TBX15; TBX15; TBX18; TBX19; TBX20; TBX20; TBX20; TBX21; TBX22; ZNF18; ZNF18; ZNF18; ZNF18 (directAnnotation). MGA; TBX21 (inferredBy_Orthology).
KLRG1	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
KLRG1	transfac_pro__M06341	ZNF790 (directAnnotation).
KLRG1	transfac_pro__M06093	ZNF17 (directAnnotation).
KLRG1	transfac_pro__M05908	ZNF319 (inferredBy_Orthology).
KLRG1	taipale_tf_pairs__GCM1_MAX_NNCACGTGNNNGCGGGYN_CAP_repr	GCM1; MAX (directAnnotation).
KLRG1	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."