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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KLK4

Summary for KLK4

Gene information	Gene symbol	KLK4
	Ensembl ID	ENSG00000167749
	Entrez ID	9622
	Gene name	kallikrein related peptidase 4
	Synonyms	EMSP\|EMSP1\|KLK-L1\|PRSS17\|PSTS
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KLK4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.26434	0.00e+00

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Expression of KLK4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLK4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KLK4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLK4	hsa-miR-6133	99.9987	NM_001302961
KLK4	hsa-miR-4510	99.9983	NM_001302961
KLK4	hsa-miR-6129	99.9983	NM_001302961
KLK4	hsa-miR-6127	99.9983	NM_001302961
KLK4	hsa-miR-6130	99.9983	NM_001302961
KLK4	hsa-miR-4756-5p	99.8404	NM_001302961
KLK4	hsa-miR-1321	99.8404	NM_001302961
KLK4	hsa-miR-4739	99.8404	NM_001302961
KLK4	hsa-miR-422a	99.1758	NM_001302961
KLK4	hsa-miR-765	98.3294	NM_001302961
KLK4	hsa-miR-11181-3p	98.3294	NM_001302961
KLK4	hsa-miR-7106-5p	98.1937	NM_001302961
KLK4	hsa-miR-378h	97.5577	NM_001302961
KLK4	hsa-miR-378f	97.5577	NM_001302961
KLK4	hsa-miR-378e	97.5577	NM_001302961
KLK4	hsa-miR-378i	97.5577	NM_001302961
KLK4	hsa-miR-378d	97.5577	NM_001302961
KLK4	hsa-miR-378b	97.5577	NM_001302961
KLK4	hsa-miR-378a-3p	97.5577	NM_001302961
KLK4	hsa-miR-378c	97.5577	NM_001302961
KLK4	hsa-miR-6875-5p	96.8745	NM_001302961
KLK4	hsa-miR-3126-5p	96.8745	NM_001302961
KLK4	hsa-miR-4779	96.4779	NM_001302961
KLK4	hsa-miR-4492	95.0523	NM_001302961
KLK4	hsa-miR-6834-5p	94.0766	NM_001302961
KLK4	hsa-miR-7845-5p	94.0531	NM_001302961
KLK4	hsa-miR-6886-5p	91.0756	NM_001302961
KLK4	hsa-miR-12119	89.9574	NM_001302961
KLK4	hsa-miR-3184-5p	88.5626	NM_001302961
KLK4	hsa-miR-423-5p	88.5626	NM_001302961
KLK4	hsa-miR-6742-3p	88.0753	NM_001302961
KLK4	hsa-miR-7162-3p	87.1033	NM_001302961
KLK4	hsa-miR-4649-3p	87.1033	NM_001302961
KLK4	hsa-miR-5001-5p	86.1108	NM_001302961
KLK4	hsa-miR-4498	86.1108	NM_001302961
KLK4	hsa-miR-762	83.3302	NM_001302961
KLK4	hsa-miR-1343-3p	81.6119	NM_001302961
KLK4	hsa-miR-6085	81.1785	NM_001302961
KLK4	hsa-miR-6813-5p	81.1785	NM_001302961
KLK4	hsa-miR-185-3p	80.6333	NM_001302961
KLK4	hsa-miR-4505	80.391	NM_001302961

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Motifs and transcription factors (TFs) regulating KLK4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."