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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KLHL7

Summary for KLHL7

Gene information	Gene symbol	KLHL7
	Ensembl ID	ENSG00000122550
	Entrez ID	55975
	Gene name	kelch like family member 7
	Synonyms	KLHL6\|RP42\|SBBI26
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KLHL7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.36213	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.292834	0.00e+00

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Expression of KLHL7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLHL7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KLHL7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLHL7	hsa-miR-4795-3p	98.5328	NM_001172428
KLHL7	hsa-miR-548e-5p	95.2037	NM_001031710
KLHL7	hsa-miR-1323	94.6145	NM_001031710
KLHL7	hsa-miR-6839-3p	93.8806	NM_001031710
KLHL7	hsa-miR-548o-3p	93.3255	NM_001031710
KLHL7	hsa-miR-12133	93.1851	NM_001031710
KLHL7	hsa-miR-96-5p	92.6818	NM_001031710
KLHL7	hsa-miR-1271-5p	92.6351	NM_001031710
KLHL7	hsa-miR-4476	92.1974	NM_001031710
KLHL7	hsa-miR-6876-5p	92.1974	NM_001031710
KLHL7	hsa-miR-4259	91.7286	NM_001031710
KLHL7	hsa-miR-32-3p	89.3846	NM_001172428
KLHL7	hsa-miR-3121-3p	88.4964	NM_001031710
KLHL7	hsa-miR-126-5p	87.1116	NM_001172428
KLHL7	hsa-miR-4760-3p	86.6179	NM_001031710
KLHL7	hsa-miR-6508-5p	86.3634	NM_001031710
KLHL7	hsa-miR-3908	86.3073	NM_001031710
KLHL7	hsa-miR-593-3p	86.2679	NM_001031710
KLHL7	hsa-miR-548an	85.8806	NM_001031710
KLHL7	hsa-miR-1303	84.7437	NM_001031710
KLHL7	hsa-miR-23c	84.5437	NM_001031710
KLHL7	hsa-miR-23b-3p	84.5437	NM_001031710
KLHL7	hsa-miR-23a-3p	84.5437	NM_001031710
KLHL7	hsa-miR-4533	84.4579	NM_001031710
KLHL7	hsa-miR-4735-5p	84.403	NM_001172428
KLHL7	hsa-miR-297	83.0856	NM_001172428
KLHL7	hsa-miR-361-5p	82.7924	NM_001031710
KLHL7	hsa-miR-8067	82.2566	NM_001031710
KLHL7	hsa-miR-183-3p	81.9011	NM_001031710
KLHL7	hsa-miR-520g-5p	81.8999	NM_001031710
KLHL7	hsa-miR-17-3p	81.5639	NM_001172428
KLHL7	hsa-miR-520d-5p	81.2193	NM_001031710
KLHL7	hsa-miR-524-5p	81.2193	NM_001031710

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Motifs and transcription factors (TFs) regulating KLHL7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KLHL7	metacluster_7.13	ZFX (directAnnotation).
KLHL7	metacluster_151.2	ZNF23 (directAnnotation).
KLHL7	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KLHL7	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
KLHL7	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."