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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KLHL6

Summary for KLHL6

Gene information	Gene symbol	KLHL6
	Ensembl ID	ENSG00000172578
	Entrez ID	89857
	Gene name	kelch like family member 6
	Synonyms	FLJ00029
	Gene type	protein_coding
	UniProtAcc	Q8WZ60

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Dataset with differentially expressed gene: KLHL6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.470058	8.43e-15

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Expression of KLHL6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLHL6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KLHL6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLHL6	hsa-miR-544b	92.2987	NM_130446
KLHL6	hsa-miR-1290	92.1431	NM_130446
KLHL6	hsa-miR-7844-5p	89.4396	NM_130446
KLHL6	hsa-miR-7977	85.2371	NM_130446
KLHL6	hsa-miR-26b-3p	85.1608	NM_130446
KLHL6	hsa-miR-3670	83.7379	NM_130446
KLHL6	hsa-miR-6892-5p	83.1925	NM_130446
KLHL6	hsa-miR-6507-3p	82.9338	NM_130446
KLHL6	hsa-miR-4500	82.1394	NM_130446
KLHL6	hsa-miR-5696	81.7293	NM_130446
KLHL6	hsa-miR-4319	81.3371	NM_130446
KLHL6	hsa-miR-6752-3p	81.0139	NM_130446
KLHL6	hsa-miR-7162-3p	80.9189	NM_130446
KLHL6	hsa-miR-876-5p	80.8469	NM_130446
KLHL6	hsa-miR-4755-5p	80.7071	NM_130446
KLHL6	hsa-miR-5006-3p	80.7071	NM_130446
KLHL6	hsa-miR-4324	80.3919	NM_130446

Page: 1

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Motifs and transcription factors (TFs) regulating KLHL6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."