Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KLHL24

Summary for KLHL24

Gene information	Gene symbol	KLHL24
	Ensembl ID	ENSG00000114796
	Entrez ID	54800
	Gene name	kelch like family member 24
	Synonyms	DRE1\|FLJ20059
	Gene type	protein_coding
	UniProtAcc	Q6TFL4

Top

Dataset with differentially expressed gene: KLHL24

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.47817	4.69e-12
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.318546	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.333772	1.74e-15
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.264448	1.22e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.293552	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.355883	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.393573	2.16e-21

Top

Expression of KLHL24 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to KLHL24

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating KLHL24

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLHL24	hsa-miR-4282	98.9686	NM_017644
KLHL24	hsa-miR-335-3p	96.6528	NM_017644
KLHL24	hsa-miR-7154-5p	96.045	NM_017644
KLHL24	hsa-miR-3163	95.653	NM_017644
KLHL24	hsa-miR-9983-3p	95.0226	NM_017644
KLHL24	hsa-miR-95-5p	95.0084	NM_017644
KLHL24	hsa-miR-124-3p	94.0702	NM_017644
KLHL24	hsa-miR-506-3p	94.0702	NM_017644
KLHL24	hsa-miR-5003-3p	94.0514	NM_017644
KLHL24	hsa-miR-548x-3p	93.7104	NM_017644
KLHL24	hsa-miR-548aj-3p	93.7104	NM_017644
KLHL24	hsa-miR-4699-3p	93.4437	NM_017644
KLHL24	hsa-miR-129-5p	93.3436	NM_017644
KLHL24	hsa-miR-377-3p	93.1507	NM_017644
KLHL24	hsa-miR-510-3p	92.9241	NM_017644
KLHL24	hsa-miR-183-5p	92.5148	NM_017644
KLHL24	hsa-miR-548j-3p	91.9855	NM_017644
KLHL24	hsa-miR-6504-3p	91.9451	NM_017644
KLHL24	hsa-miR-10399-5p	91.9451	NM_017644
KLHL24	hsa-miR-4684-5p	91.748	NM_017644
KLHL24	hsa-miR-4275	91.4291	NM_017644
KLHL24	hsa-miR-16-1-3p	91.2384	NM_017644
KLHL24	hsa-miR-5684	90.97	NM_017644
KLHL24	hsa-miR-548ae-3p	90.9459	NM_017644
KLHL24	hsa-miR-548am-3p	90.9459	NM_017644
KLHL24	hsa-miR-548aq-3p	90.9459	NM_017644
KLHL24	hsa-miR-548ah-3p	90.9459	NM_017644
KLHL24	hsa-miR-590-3p	90.8921	NM_017644
KLHL24	hsa-miR-7-1-3p	89.5812	NM_017644
KLHL24	hsa-miR-7-2-3p	89.5812	NM_017644
KLHL24	hsa-miR-520b-5p	88.9214	NM_017644
KLHL24	hsa-miR-519a-2-5p	88.9214	NM_017644
KLHL24	hsa-miR-3613-3p	88.2361	NM_017644
KLHL24	hsa-miR-1305	88.2262	NM_017644
KLHL24	hsa-miR-576-3p	88.1316	NM_017644
KLHL24	hsa-miR-4714-3p	88.1301	NM_017644
KLHL24	hsa-miR-889-3p	87.1755	NM_017644
KLHL24	hsa-miR-627-3p	86.7957	NM_017644
KLHL24	hsa-miR-518c-5p	86.1485	NM_017644
KLHL24	hsa-miR-3646	86.0074	NM_017644
KLHL24	hsa-miR-374c-5p	85.9834	NM_017644
KLHL24	hsa-miR-655-3p	85.9834	NM_017644
KLHL24	hsa-miR-219a-2-3p	85.9791	NM_017644
KLHL24	hsa-miR-4709-3p	85.889	NM_017644
KLHL24	hsa-miR-374a-3p	85.8533	NM_017644
KLHL24	hsa-miR-4496	85.676	NM_017644
KLHL24	hsa-miR-6832-5p	85.2633	NM_017644
KLHL24	hsa-miR-4427	85.1266	NM_017644
KLHL24	hsa-miR-4796-3p	84.7138	NM_017644
KLHL24	hsa-miR-4261	84.424	NM_017644

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating KLHL24

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KLHL24	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
KLHL24	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KLHL24	transfac_pro__M07397	ZNF148 (directAnnotation).
KLHL24	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
KLHL24	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
KLHL24	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
KLHL24	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
KLHL24	metacluster_7.13	ZFX (directAnnotation).
KLHL24	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
KLHL24	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
KLHL24	transfac_pro__M01175	ZBTB7B (directAnnotation).
KLHL24	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
KLHL24	tfdimers__MD00151	CHURC1 (directAnnotation).
KLHL24	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
KLHL24	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
KLHL24	transfac_pro__M01303	SP1 (directAnnotation).
KLHL24	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
KLHL24	swissregulon__hs__CHD1	CHD1 (directAnnotation).
KLHL24	transfac_pro__M02090	E2F4 (directAnnotation).
KLHL24	transfac_pro__M01714	KLF15 (directAnnotation).
KLHL24	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
KLHL24	jaspar__MA1122.1	TFDP1 (directAnnotation).
KLHL24	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
KLHL24	transfac_pro__M02089	E2F3 (directAnnotation).
KLHL24	metacluster_3.14	WT1; WT1 (directAnnotation).
KLHL24	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
KLHL24	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
KLHL24	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
KLHL24	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
KLHL24	cisbp__M07938	E2F1 (directAnnotation).
KLHL24	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
KLHL24	transfac_pro__M07436	WT1 (directAnnotation).
KLHL24	transfac_pro__M02281	SP1 (directAnnotation).
KLHL24	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
KLHL24	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
KLHL24	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
KLHL24	transfac_pro__M02898	SMAD3 (directAnnotation).
KLHL24	transfac_public__M00491	PATZ1 (directAnnotation).
KLHL24	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
KLHL24	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
KLHL24	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
KLHL24	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
KLHL24	transfac_pro__M04617	ZBTB7A (directAnnotation).
KLHL24	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
KLHL24	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
KLHL24	transfac_pro__M07387	ZBTB7A (directAnnotation).
KLHL24	transfac_pro__M00716	ZBTB14 (directAnnotation).
KLHL24	hdpi__HIP2	UBE2K (directAnnotation).
KLHL24	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
KLHL24	transfac_pro__M04893	TAF1 (directAnnotation).

Page: 1 2 3 4

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."