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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KLHL23

Summary for KLHL23

Gene information	Gene symbol	KLHL23
	Ensembl ID	ENSG00000213160
	Entrez ID	151230
	Gene name	kelch like family member 23
	Synonyms	FLJ37812\|MGC22679\|MGC2610
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KLHL23

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.647885	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.285883	0.00e+00

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Expression of KLHL23 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLHL23

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KLHL23

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLHL23	hsa-miR-5011-5p	99.9999	NM_001199290
KLHL23	hsa-miR-190a-3p	99.9982	NM_001199290
KLHL23	hsa-miR-4789-3p	99.9918	NM_001199290
KLHL23	hsa-miR-4789-5p	99.8608	NM_001199290
KLHL23	hsa-miR-466	99.6453	NM_001199290
KLHL23	hsa-miR-6867-5p	97.4879	NM_144711
KLHL23	hsa-miR-3166	95.5114	NM_144711
KLHL23	hsa-miR-3145-5p	93.0666	NM_001199290
KLHL23	hsa-miR-3924	91.8679	NM_001199290
KLHL23	hsa-miR-3973	91.3541	NM_001199290
KLHL23	hsa-miR-5692a	90.9209	NM_144711
KLHL23	hsa-miR-520d-5p	90.7924	NM_144711
KLHL23	hsa-miR-524-5p	90.7924	NM_144711
KLHL23	hsa-miR-4680-3p	90.2709	NM_001199290
KLHL23	hsa-miR-4451	89.7422	NM_144711
KLHL23	hsa-miR-1273h-3p	88.8997	NM_001199290
KLHL23	hsa-miR-9898	88.6431	NM_001199290
KLHL23	hsa-miR-624-5p	88.2185	NM_001199290
KLHL23	hsa-miR-6782-3p	88.1563	NM_001199290
KLHL23	hsa-miR-6818-3p	87.481	NM_001199290
KLHL23	hsa-miR-4643	87.0964	NM_001199290
KLHL23	hsa-miR-3675-5p	86.837	NM_001199290
KLHL23	hsa-miR-4424	85.8191	NM_001199290
KLHL23	hsa-miR-3941	85.1879	NM_144711
KLHL23	hsa-miR-7856-5p	84.9321	NM_001199290
KLHL23	hsa-miR-548az-5p	84.7999	NM_144711
KLHL23	hsa-miR-548t-5p	84.7999	NM_144711
KLHL23	hsa-miR-149-5p	83.1933	NM_144711
KLHL23	hsa-miR-944	83.1185	NM_001199290
KLHL23	hsa-miR-642a-5p	83.0232	NM_001199290
KLHL23	hsa-miR-152-5p	81.6725	NM_001199290

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Motifs and transcription factors (TFs) regulating KLHL23

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KLHL23	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
KLHL23	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
KLHL23	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
KLHL23	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
KLHL23	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
KLHL23	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
KLHL23	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
KLHL23	metacluster_3.14	WT1; WT1 (directAnnotation).
KLHL23	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
KLHL23	cisbp__M07938	E2F1 (directAnnotation).
KLHL23	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
KLHL23	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."