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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KLHL13

Summary for KLHL13

Gene information	Gene symbol	KLHL13
	Ensembl ID	ENSG00000003096
	Entrez ID	90293
	Gene name	kelch like family member 13
	Synonyms	BKLHD2\|FLJ10262\|KIAA1309
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KLHL13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.268437	0.00e+00

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Expression of KLHL13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLHL13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KLHL13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLHL13	hsa-miR-527	94.8033	NM_001168299
KLHL13	hsa-miR-518a-5p	94.8033	NM_001168299
KLHL13	hsa-miR-6768-5p	94.0896	NM_001168299
KLHL13	hsa-miR-1278	93.9847	NM_001168299
KLHL13	hsa-miR-6778-3p	93.3227	NM_001168299
KLHL13	hsa-miR-582-5p	93.1653	NM_001168299
KLHL13	hsa-miR-3613-3p	92.8294	NM_001168299
KLHL13	hsa-miR-603	92.456	NM_001168299
KLHL13	hsa-miR-625-5p	91.3376	NM_001168299
KLHL13	hsa-miR-6867-5p	91.0923	NM_001168299
KLHL13	hsa-miR-4428	91.0743	NM_001168299
KLHL13	hsa-miR-4716-3p	90.5648	NM_001168299
KLHL13	hsa-miR-6794-5p	90.5648	NM_001168299
KLHL13	hsa-miR-489-3p	90.5224	NM_001168299
KLHL13	hsa-miR-1287-3p	88.8471	NM_001168299
KLHL13	hsa-miR-4516	88.6656	NM_001168299
KLHL13	hsa-miR-4434	88.6656	NM_001168299
KLHL13	hsa-miR-2113	88.6117	NM_001168299
KLHL13	hsa-miR-4496	88.4823	NM_001168299
KLHL13	hsa-miR-7843-3p	88.3778	NM_001168299
KLHL13	hsa-miR-335-3p	88.1032	NM_001168299
KLHL13	hsa-miR-3120-3p	87.4779	NM_001168299
KLHL13	hsa-miR-4724-5p	87.1396	NM_001168299
KLHL13	hsa-miR-4777-3p	87.0469	NM_001168299
KLHL13	hsa-miR-218-5p	86.9595	NM_001168299
KLHL13	hsa-miR-4778-5p	86.6313	NM_001168299
KLHL13	hsa-miR-3180-5p	86.547	NM_001168299
KLHL13	hsa-miR-4504	86.3571	NM_001168299
KLHL13	hsa-miR-425-5p	86.2596	NM_001168299
KLHL13	hsa-miR-5703	86.2183	NM_001168299
KLHL13	hsa-miR-629-5p	85.0109	NM_001168299
KLHL13	hsa-miR-4756-5p	84.797	NM_001168299
KLHL13	hsa-miR-548av-5p	84.1921	NM_001168299
KLHL13	hsa-miR-8054	84.1921	NM_001168299
KLHL13	hsa-miR-548k	84.1921	NM_001168299
KLHL13	hsa-miR-7152-5p	83.9134	NM_001168299
KLHL13	hsa-miR-1255b-2-3p	83.747	NM_001168299
KLHL13	hsa-miR-129-2-3p	83.3117	NM_001168299
KLHL13	hsa-miR-129-1-3p	83.3117	NM_001168299
KLHL13	hsa-miR-586	82.8029	NM_001168299
KLHL13	hsa-miR-651-3p	81.2822	NM_001168299
KLHL13	hsa-miR-1321	80.9886	NM_001168299
KLHL13	hsa-miR-4739	80.9886	NM_001168299
KLHL13	hsa-miR-5010-3p	80.19	NM_001168299

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Motifs and transcription factors (TFs) regulating KLHL13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KLHL13	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
KLHL13	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
KLHL13	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
KLHL13	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
KLHL13	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
KLHL13	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
KLHL13	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
KLHL13	metacluster_3.14	WT1; WT1 (directAnnotation).
KLHL13	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
KLHL13	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."