Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KITLG

Summary for KITLG

Gene information	Gene symbol	KITLG
	Ensembl ID	ENSG00000049130
	Entrez ID	4254
	Gene name	KIT ligand
	Synonyms	DFNA69\|FPH2\|Kitl\|KL-1\|MGF\|SCF\|SF\|SLF
	Gene type	protein_coding
	UniProtAcc	P21583

Top

Dataset with differentially expressed gene: KITLG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.551531	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.563174	0.00e+00

Top

Expression of KITLG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to KITLG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating KITLG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KITLG	hsa-miR-9-3p	99.4859	NM_000899
KITLG	hsa-miR-320c	99.1823	NM_000899
KITLG	hsa-miR-320d	99.1823	NM_000899
KITLG	hsa-miR-320b	99.1823	NM_000899
KITLG	hsa-miR-320a-3p	99.1823	NM_000899
KITLG	hsa-miR-4429	99.1823	NM_000899
KITLG	hsa-miR-548au-3p	96.5837	NM_000899
KITLG	hsa-miR-4778-3p	96.2379	NM_000899
KITLG	hsa-miR-5590-3p	95.8714	NM_003994
KITLG	hsa-miR-4310	95.7867	NM_003994
KITLG	hsa-miR-4775	95.7181	NM_003994
KITLG	hsa-miR-451b	95.4504	NM_000899
KITLG	hsa-miR-7157-5p	95.293	NM_003994
KITLG	hsa-miR-4668-3p	95.0758	NM_003994
KITLG	hsa-miR-3174	94.5369	NM_000899
KITLG	hsa-miR-142-5p	94.5037	NM_003994
KITLG	hsa-miR-548k	94.4367	NM_000899
KITLG	hsa-miR-548av-5p	94.4367	NM_000899
KITLG	hsa-miR-4517	94.2315	NM_003994
KITLG	hsa-miR-9985	94.1892	NM_000899
KITLG	hsa-miR-27b-3p	94.1892	NM_000899
KITLG	hsa-miR-27a-3p	94.1892	NM_000899
KITLG	hsa-miR-4773	94.0833	NM_003994
KITLG	hsa-miR-8054	94.0571	NM_000899
KITLG	hsa-miR-4789-3p	94.056	NM_003994
KITLG	hsa-miR-548l	93.8747	NM_003994
KITLG	hsa-miR-1224-5p	93.3823	NM_000899
KITLG	hsa-miR-299-5p	92.8744	NM_003994
KITLG	hsa-miR-4291	92.7274	NM_003994
KITLG	hsa-miR-3163	92.1868	NM_000899
KITLG	hsa-miR-95-5p	91.6651	NM_000899
KITLG	hsa-miR-4659a-3p	91.2106	NM_000899
KITLG	hsa-miR-4659b-3p	91.2106	NM_000899
KITLG	hsa-miR-3160-5p	90.849	NM_003994
KITLG	hsa-miR-590-3p	90.4083	NM_003994
KITLG	hsa-miR-22-5p	90.3099	NM_000899
KITLG	hsa-miR-449a	90.3003	NM_000899
KITLG	hsa-miR-34a-5p	90.3003	NM_000899
KITLG	hsa-miR-5692a	90.0204	NM_000899
KITLG	hsa-miR-203b-3p	89.2763	NM_000899
KITLG	hsa-miR-4729	89.0774	NM_003994
KITLG	hsa-miR-802	88.6923	NM_000899
KITLG	hsa-miR-649	88.6365	NM_003994
KITLG	hsa-miR-330-3p	87.9366	NM_003994
KITLG	hsa-miR-10522-5p	86.9703	NM_003994
KITLG	hsa-miR-150-3p	86.4486	NM_003994
KITLG	hsa-miR-9-5p	86.1257	NM_003994
KITLG	hsa-miR-449b-5p	86.1148	NM_000899
KITLG	hsa-miR-34c-5p	86.1148	NM_000899
KITLG	hsa-miR-15b-3p	85.94	NM_000899

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating KITLG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KITLG	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
KITLG	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
KITLG	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
KITLG	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
KITLG	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
KITLG	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
KITLG	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
KITLG	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
KITLG	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
KITLG	transfac_pro__M00652	NRF1 (directAnnotation).
KITLG	hdpi__ETV4	ETV4 (directAnnotation).
KITLG	transfac_pro__M04866	HDAC2 (directAnnotation).
KITLG	jaspar__MA1122.1	TFDP1 (directAnnotation).
KITLG	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
KITLG	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
KITLG	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
KITLG	metacluster_135.11	NR2C2 (directAnnotation).
KITLG	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KITLG	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
KITLG	cisbp__M00968	MTF2 (directAnnotation).
KITLG	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KITLG	metacluster_160.20	JUND; PRDM15 (directAnnotation).
KITLG	cisbp__M00341	PAX6 (directAnnotation).
KITLG	metacluster_198.3	ZFP64 (directAnnotation).
KITLG	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
KITLG	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
KITLG	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
KITLG	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
KITLG	cisbp__M00788	ZFY (inferredBy_Orthology).
KITLG	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
KITLG	metacluster_175.1	ZNF283 (directAnnotation).
KITLG	hdpi__ZNF304	ZNF304 (directAnnotation).
KITLG	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
KITLG	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
KITLG	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
KITLG	transfac_pro__M01199	TRIM28 (directAnnotation).
KITLG	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
KITLG	metacluster_151.2	ZNF23 (directAnnotation).
KITLG	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KITLG	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KITLG	transfac_pro__M03806	ZBTB7C (directAnnotation).
KITLG	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."