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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KIR3DL1

Summary for KIR3DL1

Gene information	Gene symbol	KIR3DL1
	Ensembl ID	ENSG00000276379
	Entrez ID	3811
	Gene name	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1
	Synonyms	AMB11\|CD158E1\|CD158e1/2\|CD158e2\|cl-11\|cl-2\|KIR\|nkat3\|NKB1\|NKB1B
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KIR3DL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE212217	patients	Peripheral blood mononuclear cells	Endometrial cancer	Epigenetic MMRd endometrial carcinoma	Immunotherapy	pembrolizumab	pre	NK cells	-0.342202	0.00e+00

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Expression of KIR3DL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KIR3DL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KIR3DL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KIR3DL1	hsa-miR-4671-5p	86.9247	NM_013289
KIR3DL1	hsa-miR-297	82.8375	NM_013289
KIR3DL1	hsa-miR-5690	81.4334	NM_013289
KIR3DL1	hsa-miR-5697	80.2659	NM_013289

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Motifs and transcription factors (TFs) regulating KIR3DL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KIR3DL1	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
KIR3DL1	transfac_pro__M06015	ZNF729 (directAnnotation).
KIR3DL1	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
KIR3DL1	kznf__ZNF77_Imbeault2017_OM_MEME	ZNF77 (directAnnotation).
KIR3DL1	tfdimers__MD00351	IRF8; RFX1; RFX2; RFX3; RFX4; RFX5; RFXANK; RFXAP (directAnnotation).
KIR3DL1	metacluster_172.21	SPDEF (inferredBy_Orthology).
KIR3DL1	jaspar__MA1979.1	ZNF383 (directAnnotation).
KIR3DL1	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
KIR3DL1	homer__AGGCCTGG_ZFX	ZFY (inferredBy_Orthology).
KIR3DL1	transfac_pro__M06058	ZNF253 (directAnnotation).
KIR3DL1	hdpi__ZNF323	ZSCAN31 (directAnnotation).
KIR3DL1	taipale_tf_pairs__POU2F1_ELK1_NCCGGATATGCAN_CAP	ELK1; POU2F1 (directAnnotation).
KIR3DL1	metacluster_22.3	MAFK (inferredBy_Orthology).
KIR3DL1	tfdimers__MD00026	IRF1; MYB (directAnnotation).
KIR3DL1	hocomoco__ZFX_MOUSE.H11MO.1.B	ZFY (inferredBy_Orthology).
KIR3DL1	metacluster_2.5	BATF3 (directAnnotation). BATF; IRF8 (inferredBy_Orthology).
KIR3DL1	taipale_tf_pairs__SOX6_TBX21_RGGTGTNNNNNNNNNYATTGT_CAP_repr	SOX6; TBX21 (directAnnotation).
KIR3DL1	metacluster_22.2	MAFK (directAnnotation).
KIR3DL1	metacluster_22.6	MAFG (directAnnotation).
KIR3DL1	metacluster_162.1	ZNF224 (directAnnotation).
KIR3DL1	transfac_pro__M00992	FOXP3 (directAnnotation).
KIR3DL1	metacluster_22.4	MAFG (inferredBy_Orthology).
KIR3DL1	transfac_pro__M04844	MAX (directAnnotation).
KIR3DL1	transfac_pro__M06832	PEG3 (directAnnotation).
KIR3DL1	metacluster_182.10	ZFX (directAnnotation).
KIR3DL1	transfac_pro__M06627	ZNF570 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."