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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KIN

Summary for KIN

Gene information	Gene symbol	KIN
	Ensembl ID	ENSG00000151657
	Entrez ID	22944
	Gene name	Kin17 DNA and RNA binding protein
	Synonyms	KIN17\|Rts2
	Gene type	protein_coding
	UniProtAcc	O60870

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Dataset with differentially expressed gene: KIN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.254756	3.95e-19
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.351748	0.00e+00

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Expression of KIN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KIN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KIN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KIN	hsa-miR-3613-3p	97.8368	NM_012311
KIN	hsa-miR-548c-3p	96.2012	NM_012311
KIN	hsa-miR-548z	95.5355	NM_012311
KIN	hsa-miR-548ac	95.5355	NM_012311
KIN	hsa-miR-548h-3p	95.5355	NM_012311
KIN	hsa-miR-548bb-3p	95.1018	NM_012311
KIN	hsa-miR-548d-3p	95.1018	NM_012311
KIN	hsa-miR-548n	92.6933	NM_012311
KIN	hsa-let-7a-3p	91.9032	NM_012311
KIN	hsa-let-7f-1-3p	91.9032	NM_012311
KIN	hsa-let-7b-3p	91.9032	NM_012311
KIN	hsa-miR-98-3p	91.9032	NM_012311
KIN	hsa-miR-607	91.7246	NM_012311
KIN	hsa-miR-4272	89.1539	NM_012311
KIN	hsa-miR-297	88.6758	NM_012311
KIN	hsa-miR-587	85.3827	NM_012311
KIN	hsa-miR-6760-5p	84.9638	NM_012311
KIN	hsa-miR-4691-5p	84.4228	NM_012311
KIN	hsa-miR-543	83.6889	NM_012311
KIN	hsa-miR-3681-5p	83.1315	NM_012311
KIN	hsa-miR-335-3p	82.6762	NM_012311
KIN	hsa-miR-373-5p	82.3496	NM_012311
KIN	hsa-miR-616-5p	82.3496	NM_012311
KIN	hsa-miR-371b-5p	82.3496	NM_012311
KIN	hsa-miR-4524a-3p	81.6915	NM_012311
KIN	hsa-miR-6792-3p	81.5923	NM_012311
KIN	hsa-miR-4496	81.3199	NM_012311
KIN	hsa-miR-5572	81.2821	NM_012311
KIN	hsa-miR-556-3p	80.6485	NM_012311
KIN	hsa-miR-524-5p	80.4521	NM_012311
KIN	hsa-miR-520d-5p	80.4521	NM_012311

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Motifs and transcription factors (TFs) regulating KIN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KIN	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
KIN	transfac_pro__M04826	EP300 (directAnnotation).
KIN	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
KIN	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."