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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KIF3C

Summary for KIF3C

Gene information	Gene symbol	KIF3C
	Ensembl ID	ENSG00000084731
	Entrez ID	3797
	Gene name	kinesin family member 3C
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O14782

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Dataset with differentially expressed gene: KIF3C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.41655	2.18e-06
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.499023	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.258134	2.65e-25

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Expression of KIF3C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KIF3C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KIF3C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KIF3C	hsa-miR-190a-3p	99.9895	NM_002254
KIF3C	hsa-miR-5011-5p	99.8647	NM_002254
KIF3C	hsa-miR-133a-3p	96.4267	NM_002254
KIF3C	hsa-miR-133b	96.4267	NM_002254
KIF3C	hsa-miR-6878-5p	94.3854	NM_002254
KIF3C	hsa-miR-5692a	94.1549	NM_002254
KIF3C	hsa-miR-7159-5p	92.2804	NM_002254
KIF3C	hsa-miR-4692	90.5222	NM_002254
KIF3C	hsa-miR-7977	90.3035	NM_002254
KIF3C	hsa-miR-5586-3p	90.2737	NM_002254
KIF3C	hsa-miR-24-3p	90.2303	NM_002254
KIF3C	hsa-miR-1305	90.0214	NM_002254
KIF3C	hsa-miR-3065-5p	89.714	NM_002254
KIF3C	hsa-miR-183-3p	89.5043	NM_002254
KIF3C	hsa-miR-4514	88.2905	NM_002254
KIF3C	hsa-miR-5009-3p	88.2187	NM_002254
KIF3C	hsa-miR-8485	86.4268	NM_002254
KIF3C	hsa-miR-6124	86.2919	NM_002254
KIF3C	hsa-miR-4294	85.9136	NM_002254
KIF3C	hsa-miR-3132	85.3456	NM_002254
KIF3C	hsa-miR-655-5p	83.2547	NM_002254
KIF3C	hsa-miR-6721-5p	83.2057	NM_002254
KIF3C	hsa-miR-197-5p	82.8015	NM_002254
KIF3C	hsa-miR-7515	82.4914	NM_002254
KIF3C	hsa-miR-6778-5p	82.1236	NM_002254
KIF3C	hsa-miR-6834-3p	81.8226	NM_002254

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Motifs and transcription factors (TFs) regulating KIF3C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KIF3C	transfac_pro__M05628	ZNF735 (directAnnotation).
KIF3C	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
KIF3C	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
KIF3C	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."